A5012603955- Hereditary Neurological Disorders
- Magnesium in Health and Disease
- Genetic Neurodegenerative Diseases
- Trace Elements in Health
- Catalytic Alkyne Reactions
- Neurological diseases and metabolism
- Cyclopropane Reaction Mechanisms
- Parathyroid Disorders and Treatments
- Aluminum toxicity and tolerance in plants and animals
- Catalytic Cross-Coupling Reactions
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
New York University
2023-2024
Montana State University
2018-2021
Magnesium(II) plays catalytic, structural, regulatory, and signaling roles in living organisms. Abnormal levels of this metal have been associated with numerous pathologies, including cardiovascular disease, diabetes, metabolic syndrome, immunodeficiency, cancer, and, most recently, liver pathologies affecting humans. The role Mg2+ the pathophysiology however, has occluded by concomitant changes concentration interfering divalent cations, such as Ca2+, which complicates interpretation...
An auto-tandem catalytic double allylic rearrangement of N-alloc-N-allyl ynamides was developed. This reaction proceeds through two separate and distinct cycles with both decarboxylative Pd-π-allyl Pd(0)-promoted aza-Claisen rearrangements occurring. A detailed mechanistic study supported by computations highlights these mechanisms. Previously unreported reversible C-N ionization a Pd(0)-catalyzed [3,3]-sigmatropic were discovered. provides new pathways for π-allyl sigmatropic rearrangements.
ABSTRACT Familial dysautonomia (FD) is an autosomal recessive disorder marked by developmental and progressive neuropathies. It caused intronic point-mutation in the IKBKAP/ELP1 gene, which encodes inhibitor of κB kinase complex-associated protein (IKAP, also called ELP1), a component elongator complex. Owing to variation tissue-specific splicing, mutation primarily affects nervous system. One most debilitating hallmarks FD that patients' quality life blindness. To determine...