A5045616234- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Medical Imaging Techniques and Applications
- Autism Spectrum Disorder Research
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Lanthanide and Transition Metal Complexes
- Genetics and Neurodevelopmental Disorders
- Tryptophan and brain disorders
- Advanced Neuroimaging Techniques and Applications
- MicroRNA in disease regulation
- Cancer-related cognitive impairment studies
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Interference and Gene Delivery
- Radiomics and Machine Learning in Medical Imaging
- Stress Responses and Cortisol
- Pharmacological Effects and Toxicity Studies
- Health, Environment, Cognitive Aging
- Amino Acid Enzymes and Metabolism
- Circular RNAs in diseases
- Machine Learning in Healthcare
- Neuroscience and Neuropharmacology Research
- Neurological Disease Mechanisms and Treatments
- Adenosine and Purinergic Signaling
- Nerve injury and regeneration
University of Pittsburgh
2023-2025
Universidade Federal do Rio Grande do Sul
2018-2024
Fundação Oswaldo Cruz
2018-2023
Universidade Federal do Rio Grande
2018-2022
University of Central Lancashire
2021
Hospital de Clínicas de Porto Alegre
2018
Abstract INTRODUCTION Epidemiological studies indicate a link between attention‐deficit/hyperactivity disorder (ADHD) and elevated risk of dementia. However, the impact ADHD on cognition Alzheimer's disease (AD) biomarkers in individuals with cognitive impairment remains unclear. METHODS We computed weighted polygenic scores (ADHD‐PRS) 938 cognitively impaired participants (674 mild [MCI] 264 dementia; mean age 73.5 years). A subset underwent cerebrospinal fluid (CSF) analysis for amyloid...
Autism spectrum disorder (ASD) is characterized by impairments in both social communication and interaction repetitive or stereotyped behaviors. Although its etiology remains unknown, genetic environmental risk factors have been associated with this disorder, including the exposure to valproic acid (VPA) during pregnancy. Resveratrol (RSV) an anti-inflammatory antioxidant molecule known prevent VPA animal model of autism. This study aimed analyze effects prenatal VPA, as well possible...
Intracellular alpha-synuclein aggregates, known as Lewy bodies (LB), are commonly observed in Alzheimer's disease (AD) dementia. Post-mortem studies have shown a higher frequency of neuropsychiatric symptoms among individuals with AD and LB co-pathology. However, the effects vivo-measured pathology on remain underexplored. This study aimed to evaluate cross-sectional longitudinal across continuum. We analyzed data from 1,169 participants Disease Neuroimaging Initiative (ADNI). Participants...
Autism spectrum disorder can present a plethora of clinical conditions associated with the disorder, such as greater brain volume in first years life significant percentage patients. We aimed to evaluate water content, blood-brain barrier permeability, and expression aquaporin 1 4, GFAP valproic acid-animal model, assessing effect resveratrol. On postnatal day 30, Wistar rats acid group showed permeability Evans blue dye higher proportion volume, prevented both by Prenatal exposition...
Autism spectrum disorder (ASD) is a prevalent neurodevelopmental characterized by several alterations, including disorganized brain cytoarchitecture and excitatory/inhibitory (E/I) imbalance. We aimed to analyze aspects associated with the inhibitory components in ASD, using bioinformatics develop notions about embryonic life tissue analysis for postnatal life. analyzed microarray RNAseq datasets of embryos from different ASD models, demonstrating that regions involved neuronal development...
<title>Abstract</title> Previous studies have shown that glial and neuronal changes may trigger synaptic dysfunction in Alzheimer’s disease(AD). However, the link between markers abnormalities living brain is poorly understood. Here, we investigated association biomarkers of astrocyte microglial reactivity 478 individuals across aging AD spectrum from two cohorts with available CSF measures amyloid-β(Aβ), phosphorylated tau(pTau181), reactivity(GFAP), activation(sTREM2), biomarkers(GAP43...
This article contains data of Social Transmission Food Preference in an animal model autism and the evaluation a set microRNA analyzed autistic patients autism. The analyses absolute consumption two flavored food by male rats prenatally exposed to valproic acid (VPA) treated with resveratrol (RSV), showed that VPA animals show trend eat less presented demonstrator rat. We also identified 13 similar levels among rodents' experimental groups, as well 11 no alterations between control subjects....
Considering the potential role of lymphocytes in pathophysiology autism spectrum disorder (ASD), we aimed to evaluate possible alterations T cell pools lymphoid organs an animal model induced by valproic acid (VPA). Pregnant Swiss mice received a single intraperitoneal injection 600 mg/kg VPA (VPA group) or saline (control on day 11 gestation. Male offspring were euthanized postnatal 60 for removal thy-muses, spleens, and pool inguinal, axillary brachial lymph nodes. Cellularity was...
Abstract Background Alzheimer’s disease (AD) is classically viewed as a predominantly amnestic syndrome, with other cognitive and neuropsychiatric symptoms (NPS) being non‐integral associations. Emerging Evidence suggests that within typical AD, these are core features from the onset. Methods We employed K‐modes clustering on 2483 cognitively impaired (CI) individuals (CDR ≥ 0.5), excluding participants diagnosed atypical non‐amnestic MCI, or CI due to non‐AD dementias five cohorts: TRIAD,...
Abstract Background The newly proposed criteria by the AA working group incorporates both biological and clinical stages to characterize progression of AD. In this study, we aim evaluate agreement between these two complementary systems. Methods Using 188 participants from McGill TRIAD 139 HEAD cohorts, categorized into (0‐4) using amyloid PET, tau PET(MK‐6240), measures as described group. Participants were then stratified three categories: congruent (clinical = biological), higher in stage...
Abstract Background Recent studies showed that neuroinflammation plays a key role in triggering specific neuropsychiatric symptoms (NPS), such as irritability and agitation, individuals with Alzheimer’s disease (AD). While prior an association between tau pathology all NPS domains, the extent to which influences each domain remains unclear. Here, we aim investigate of domains AD continuum. We hypothesize comparatively greater effect on emergence psychotic compared other domains. Method...
Abstract Background Recent studies have shown that patients with attention‐deficit/hyperactivity disorder (ADHD) are more likely to be diagnosed mild cognitive impairment (MCI) and Alzheimer’s Disease (AD). Increased genetic risk for ADHD, measured ADHD polygenic scores (ADHD‐PRS), was associated a severe AD presentation, including worse function higher tau pathology. Neuropsychiatric symptoms (NPSs) common in hypothesized occur disease progression. It is unclear whether predispose...
Abstract Background Dysregulation of cholesterol metabolism contributes to the increase cerebral vascular diseases, favoring development dementia. In this sense, high levels high‐density lipoprotein (HDL) are considered protective against outcomes associated with cardiovascular diseases. However, little is known about effect plasma HDL alterations volume in non‐vascular AD and individuals. Here we evaluated association brain neurofilament light chain (NfL) levels. Method We analyzed 135...
Abstract Background Default mode network (DMN) resting state connectivity has been correlated with heightened amyloid and tau – hallmarks of Alzheimer's Disease (AD). Tau is postulated to impact a meta‐temporal area including DMN‐associated regions like amygdala, entorhinal cortex, fusiform gyrus, parahippocampus, inferior temporal, middle temporal gyrus. We recruited individuals varying cognitive status undergo imaging two tracers (Flortaucipir MK6240). investigated the association between...
Abstract Background We showed that plasma GFAP (a proxy of astrocyte reactivity) abnormality is key to unleashing Aβ effects on tau phosphorylation in preclinical AD. This suggests selecting cognitively unimpaired(CU) individuals with both high and could offer an early time window the disease, but increased risk developing pathology. Here, we tested utility for population enrichment clinical trials focusing CU individuals. Method assessed 195 from TRIAD (n=84) WRAP (n=111) cohorts Aβ‐PET at...
Abstract Background Tau PET provides continuous measurements of tau tangle pathology in the human brain. However, establishing cutoffs is crucial for selecting individuals treatment clinical trials or practice. In absence postmortem data, must be established using statistical methods based on what considered normal tracer uptake. this study, we tested impact various to determine positivity two different tracers scanned head‐to‐head. Methods We studied 147 from Head‐to‐Head Harmonization...
Abstract Background Harmonization of the two most commonly used Tau PET tracers, 18F‐Flortaucipir and 18F‐MK6240 has proven to be complex. Unlike centiloid scale for amyloid SUVRs tracers are not linearly comparable vary markedly in dynamic range sensitivity. Method Braak stage (1‐6) were obtained from Longitudinal multicenter head‐to‐head harmonization tau‐PET (HEAD) project. For training, we 13 confirmed AD, 24 MCI 66 negative controls. To assess linearity correlations with...
Abstract Background Tau PET tracers are employed to measure the accumulation of tau in vivo brain. Each tracer possesses unique characteristics, including binding affinity, sensitivity, and specificity aggregates. This study leverages HEAD dataset, which is currently performing baseline conducting multiple clinical cognitive assessments. The objective this elucidate relationship between [ 18 F]Flortaucipir F]MK6240 commonly used tests general performance. Methods We assessed 170 individuals...
Abstract Background Identifying individuals’ levels of tau PET pathology could prove to be beneficial in clinical settings, given that emerging therapies aimed reducing Aβ seem most effective these individuals. Here, we present the cases four patients who visited memory clinic at University Pittsburgh Medical Center between June and December 2023 underwent both tau‐PET scans. Method These individuals had standard cognitive outcomes, typical blood tests order with impairment, MRI, and, as...