A5036820839- Fungal and yeast genetics research
- Prion Diseases and Protein Misfolding
- Genetically Modified Organisms Research
- Carcinogens and Genotoxicity Assessment
- RNA Research and Splicing
- Plant nutrient uptake and metabolism
- Insect and Pesticide Research
- Biochemical and Molecular Research
- DNA Repair Mechanisms
- Amino Acid Enzymes and Metabolism
- CRISPR and Genetic Engineering
- Radiation Effects and Dosimetry
- Yeasts and Rust Fungi Studies
- Microtubule and mitosis dynamics
- Plant Genetic and Mutation Studies
- Alzheimer's disease research and treatments
St Petersburg University
2015-2025
Vavilov Institute of General Genetics
2020-2025
Adenylosuccinate synthetase (AdSS), encoded by the ADE12 gene in yeast Saccharomyces cerevisiae, plays a critical role purine biosynthesis, catalyzing conversion of inosine 5'-monophosphate (IMP) and aspartic acid to adenylosuccinate, substrate for following adenosine (AMP) synthesis step. Mutants lacking AdSS activity exhibit range pleiotropic phenotypes: slow growth, poor spore germination, accumulation, secretion hypoxanthine. We report new phenotypes ade12 mutants explain their molecular...
Spontaneous or induced DNA lesions can result in stable gene mutations and chromosomal aberrations due to their inaccurate repair, ultimately resulting phenotype changes. Some per se may interfere with transcription, leading temporary phenocopies of mutations. The direct impact primary on before removal by repair is not well understood. To address this question, we used the alpha-test, which allows for detecting various genetic events hereditary changes mating type α→a heterothallic strains...
Polyploidization is involved in a variety of biological processes. It one the principal mechanisms new species formation since it provides material for gene diversification and subsequent selection. Multiple cases polyploidization were registered different branches evolutionary tree eukaryotes. Besides its role evolution, affects expression living cells: pathological genome duplications often happen cancer cells. The consequences are being studied extensively. However, quantitative...
Background. A lot of neurodegenerative diseases are coursed by amiloidization proteins in nerve tissues. In the patients brains suffered from Alzheimer’s disease high fraction cells with abnormal chromosome amount was revealed. There some data showing that prion form protein PrP may prevent segregation mitosis. But direct association prionisation and genome stability not Materials methods. We compared yeast S. cerevisiae strain bearing termination translation factor Sup35, non-prionized...