A5064064748- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Capillary Electrophoresis Applications
- Additive Manufacturing and 3D Printing Technologies
- Heat Transfer and Boiling Studies
- Surface Modification and Superhydrophobicity
- 3D Printing in Biomedical Research
- Microfluidic and Bio-sensing Technologies
- Electrohydrodynamics and Fluid Dynamics
- Material Properties and Processing
- Music Technology and Sound Studies
- Reproductive Health and Technologies
- Nanopore and Nanochannel Transport Studies
- Fluid Dynamics and Mixing
- Electrowetting and Microfluidic Technologies
- Advanced Sensor and Energy Harvesting Materials
- Lattice Boltzmann Simulation Studies
- Sperm and Testicular Function
- Reproductive Biology and Fertility
University of Washington
2022-2025
Abstract Free‐standing tissue structures tethered between pillars are powerful mechanobiology tools for studying cell contraction. To model interfaces ubiquitous in natural tissues and upgrade existing single‐region suspended constructs, we developed Suspended Tissue Open Microfluidic Patterning (STOMP), a method to create multi‐regional tissues. STOMP uses open microfluidics capillary pinning pattern subregions within free‐standing tissues, facilitating the study of complex interfaces, such...
The true value of the contact angle between a liquid and solid is thorny problem in capillary microfluidics. Lucas-Washburn-Rideal (LWR) law assumes constant during fluid penetration. However, recent experimental studies have shown lower velocities than those predicted by LWR equation, which are attributed to velocity-dependent dynamic that larger its static value. Inspection penetration closed channels has confirmed needed equation. In this work, an open-channel configuration investigated...
Sperm cryopreservation is important for many individuals across the globe. Recent studies show that vitrification a valuable approach maintaining sperm quality after freeze–thawing processes and requires sub-microliter to microliter volumes. A major challenge adoption of in fertility laboratories ability pipet small volumes sample. Here, we present an open droplet generator leverages open-channel microfluidics passively generate purified human samples preserves kinematics. We conclude our...
The Lucas-Washburn-Rideal law is commonly applied to describe capillary flow dynamics in closed or open channels, microporous media, such as paper pads and fiber threads even granulous soil. It assumes a viscous regime where forces are counteracted by friction with the solid structure, valid assumption given small velocities device dimensions. However, scenarios exist outside regime, inertial effects become significant, meaning do not fully balance. One well-documented case transient at...
The search for efficient capillary pumping has led to two main directions investigation: first, assembly of channels provide high pressures, and second, imbibition in absorbing fibers or paper pads. In the case open microfluidics (i.e., where top boundary fluid is contact with air instead a solid wall), coupling between pads unites approaches provides enhanced pumping. this work, we investigate trees—networks mimicking branches tree—with placed at extremities channels, small networks leaves....
Sperm cryopreservation is important for many individuals across the globe. Recent studies show that vitrification a valuable approach maintaining sperm quality after freeze-thawing processes and requires sub-microliter to microliter volumes. A major challenge adoption of in fertility laboratories ability pipette small volumes sample. Here, we present an open droplet generator leverages open-channel microfluidics passively generate purified human samples preserves kinematics. We conclude our...
Abstract Trigger valves are fundamental features in capillary-driven microfluidic systems that stop fluid at an abrupt geometric expansion and release when there is flow orthogonal channel connected to the valve. The concept was originally demonstrated closed-channel capillary circuits. We show here trigger can be successfully implemented open channels. also a series of open-channel placed alongside or opposite main resulting layered flow. developed closed form model for dynamics based on...
ABSTRACT Cell-laden hydrogel constructs suspended between pillars are powerful tools for modeling tissue structure and physiology, though current fabrication techniques often limit them to uniform compositions. In contrast, tissues complex in nature with spatial arrangements of cell types extracellular matrices. Thus, we present Suspended Tissue Open Microfluidic Patterning (STOMP), which utilizes a removable, open microfluidic patterning channel pattern multiple regions across single...
Trigger valves are fundamental features in capillary-driven microfluidic systems that stop fluid at an abrupt geometric expansion and release when there is flow orthogonal channel connected to the valve. The concept was originally demonstrated closed-channel capillary circuits. We show here trigger can be successfully implemented open channels. also a series of open-channel placed alongside or opposite main resulting layered flow. developed closed form model for dynamics based on average...
Abstract The true value of the contact angle between a liquid and solid is thorny problem in capillary microfluidics. Lucas-Washburn-Rideal (LWR) law assumes constant during fluid penetration. However, recent experimental studies have shown lower velocities than predicted by LWR equation, which are attributed to velocity-dependent dynamic that larger its static value. Inspection penetration closed channels has confirmed needed equation. In this work, an open channel configuration...
ABSTRACT The search for efficient capillary pumping has led to two main directions investigation: first, assembly of channels provide high pressures, and second, imbibition in absorbing fibers or paper pads. In the case open microfluidics (i.e., where top boundary fluid is contact with air instead a solid wall), coupling between pads unites approaches provides enhanced pumping. this work, we investigate trees— networks mimicking branches tree—with placed at extremities channels, small...