Disinhibition-induced bursting activity in cultures of fetal rat spinal cord is mainly controlled by intrinsic spiking with subsequent recurrent excitation the network through glutamate synaptic transmission, and autoregulation neuronal excitability. Here we investigated contribution electrogenic Na/K pump to excitability using extracellular recordings multielectrode arrays (MEAs) intracellular whole cell from interneurons. The blockade strophanthidin led an immediate transient increase...

Purpose: To describe 10 patients with Morbihan syndrome, a rare condition characterized by the slow appearance of erythema and solid edema on upper portion face, review literature. Methods: Retrospective case series review. Results: The majority were male (80%), mean age at presentation was 67 years (range, 48–88 years); 60% had asymmetrical disease (affecting mainly right side). All subjects underwent lid biopsy to support diagnosis which showed features inflammation vascular dysfunction,...

PURPOSE: To compare the mean change in aberrations produced by a mechanical microkeratome and femtosecond laser. METHODS: This was retrospective study of 62 consecutive near emmetropic eyes that underwent LASIK satisfied following criteria: negligible laser ablation (for spherical equivalent 0.00 to +0.50 diopters maximum meridian diopters), preoperative at least 3 months postoperative Placido-based corneal aberrometry (ATLAS; Carl Zeiss Meditec, Jena, Germany). Eyes were divided into two...

Purpose: To investigate oculoplastic conditions in patients diagnosed with coronavirus disease 2019 (COVID-19) seen at ophthalmology departments of three tertiary referral centers the United Kingdom and States, review literature. Methods: Retrospective multicenter case series studied over 18 months. Results: A total four developed eyelid, orbital, or lacrimal gland pathology within weeks testing positive for COVID-19. All were male, mean age presentation was 49 (range, 31–58 years)....

Yvon, Camille MBBS, MSc; Patel, Bhupendra MD, MBChB; Malhotra, Raman MBChB Author Information

Purpose: To assess epiphora outcomes using the TEARS grading score in patients with concomitant meibomian gland inversion (MGI) and facial nerve palsy (FNP) undergoing correction of MGI. Methods: Retrospective, 5-year, noncomparative, single-center study MGI FNP, treated correction, under supervision a single surgeon. A validated “TEAR” was used to changes epiphora. Results: Ten MGI, were analyzed from group 160 FNP who underwent surgery between 2017 2022. The mean age at 50 years (range,...

Purpose To evaluate outcomes of fornix deepening with retractor recession and repositioning for conjunctivochalasis (CCh) on improvement conjunctival folds ocular surface symptoms, particularly epiphora. Methods Retrospective, single-centre, observational case series patients refractory CCh who underwent recession. was graded using the Hoh classification (grades 0 to 3 depending number height folds). Epiphora, reflex tearing, dry eye symptoms were assessed validated 'TEAR' score pre-...

Background: Floppy eyelid syndrome (FES) is a common and underdiagnosed condition characterized by hyperlaxity with reactive palpebral conjunctivitis that can cause ocular irritation. It may be associated meibomian gland dysfunction (MGD) secondary tarsal curling, resulting in upper inversion (MGI) the absence of obvious marginal entropion. Purpose: To highlight possible significance MGI patients FES report findings outcomes concomitant undergoing correction or without horizontal tightening....

Background/Aims To review the clinicopathological features of caruncle biopsies carried out at a district general hospital in United Kingdom (UK), and compare with other centres where data has been published. Methods Retrospective, single-centre, observational case series between 2004–2020. Results A total 31 lesions from patients were analysed. 18 men (58%), age ranged 12 to 91 years. 13 different histopathological types identified our series, including 9 melanocytic nevi (29%), 7 benign...

Vertebral artery dissection is an important cause of stroke in the young and diagnosis often challenging as symptoms are varied subtle. A 33-year-old, previously healthy, white male office worker was stretching his neck when he developed sudden left-sided visual loss lasting 5 minutes associated with headache. He had no other neurological or signs. investigated a computed tomography angiogram, which revealed left vertebral right posterior cerebral vascular occlusion. We describe atypical...

Objective: A chalazion is one of the most common presentations in ophthalmology practice and often diagnosed managed busy, one-stop surgical clinics by junior doctors allied health professionals.

Sino-orbital aspergillosis is an uncommon but aggressive infection. It rarely originates from the frontal sinus due to complex anatomy of recess and anteromedial position its ostium. An 87-year-old man Nigerian heritage with a history multiple myeloma, chronic kidney disease type 2 diabetes, presented eye clinic right tense swollen eyelid proptosis. Computed tomography (CT) magnetic resonance imaging (MRI) scan revealed superomedial mass communicating biopsy confirmed orbital aspergilloma....