A5069442538- Breast Implant and Reconstruction
- Breast Cancer Treatment Studies
- Reconstructive Surgery and Microvascular Techniques
- Burn Injury Management and Outcomes
- Nasal Surgery and Airway Studies
- Ear Surgery and Otitis Media
- Melanoma and MAPK Pathways
- Computational Drug Discovery Methods
- Testicular diseases and treatments
- Reconstructive Facial Surgery Techniques
- Nail Diseases and Treatments
- Pleural and Pulmonary Diseases
- Immunotherapy and Immune Responses
- Cutaneous Melanoma Detection and Management
- Trauma Management and Diagnosis
- bioluminescence and chemiluminescence research
- Breast Lesions and Carcinomas
- Digital Imaging in Medicine
- Dupuytren's Contracture and Treatments
- T-cell and B-cell Immunology
- Genital Health and Disease
- History of Medical Practice
- Pressure Ulcer Prevention and Management
- Hematological disorders and diagnostics
- Cancer, Stress, Anesthesia, and Immune Response
Portsmouth Hospitals NHS Trust
2006-2017
Newcastle upon Tyne Hospitals NHS Foundation Trust
2017
Northumbria Healthcare NHS Foundation Trust
2017
Gloucestershire Hospitals NHS Foundation Trust
2017
Royal Marsden Hospital
2017
NHS Lothian
2017
Broomfield Hospital
2017
Queen Alexandra Hospital
2003-2014
Hammersmith Hospital
2007-2008
Royal Hospital Haslar
2006-2007
Abstract Background Tumor resistance to chemotherapy may be present at the beginning of treatment, develop during or become apparent on re-treatment patient. The mechanisms involved are usually inferred from experiments with cell lines, as studies in tumor-derived cells difficult. Studies human tumors show that adapt chemotherapy, but it has been largely assumed clonal selection leads recurrent tumors. Methods Cells derived 47 breast, ovarian, esophageal, and colorectal origin 16 paired...
Cutaneous melanoma is highly immunogenic, yet primary melanomas and metastases develop successfully in otherwise immunocompetent patients. To investigate the local immunosuppressive microenvironment, we examined presence of suppressor T lymphocytes tolerising dendritic cells (DCs), expression cytokines (IL-10, TGFβ1 TGFβ2) enzyme indoleamine 2,3-dioxygenase (IDO) using qRT–PCR immunohistochemistry skin melanomas, negative positive sentinel lymph nodes (SLN), with advanced metastases. Our...
Dupuytren's disease may present with well-defined subcutaneous cords or as more diffuse involvement of the skin. Fasciectomy is procedure commonly carried out for full range disease, but associated rates recurrence up to 66%. We reviewed 143 rays in 103 patients undergoing dermofasciectomy found 12 (8.4% rays; 11.6% patients) during a mean follow-up 5.8 years, eight and four nodules. suggest that better method control than fasciectomy type
The recent discovery of activating mutations in the BRAF gene many cutaneous melanomas led us to screen genomic sequence exons 11 and 15 a series 48 intraocular (uveal) melanomas, together with control samples from three SK-Mel-28 cell line, which has mutation. same mutation was detected two-thirds our melanoma samples, but not present any uveal melanomas. This finding further underlines distinction between suggests that inhibitors are unlikely benefit patients melanoma.
Dupuytren’s disease may present with well-defined subcutaneous cords or as more diffuse involvement of the skin. Fasciectomy is procedure commonly carried out for full range disease, but associated rates recurrence up to 66%. We reviewed 143 rays in 103 patients undergoing dermofasciectomy found 12 (8.4% rays; 11.6% patients) during a mean follow-up 5.8 years, eight and four nodules. suggest that better method control than fasciectomy type
The tricyclic antidepressants have previously been shown to exert activity against glioma cells in vitro. Initial studies cell lines suggested that this might extend melanoma cells. We therefore conducted a study primary cultures from metastatic cutaneous deposits using well established ATP-based tumour chemosensitivity assay confirm and these findings. Two eight were exposed three drugs, amitriptyline, nortriptyline clomipramine, at concentrations ranging 200 6.25 µmol/l the assay. All...
Background Chemotherapy benefits relatively few patients with cutaneous melanoma. The assessment of tumour chemosensitivity by the ATP-based assay (ATP-TCA) has shown strong correlation outcome in melanoma, but requires fresh tissue and dedicated laboratory facilities. Aim To examine whether results ATP-TCA correlate expression genes known to be involved resistance chemotherapy, based on hypothesis that molecular basis lies within drug mechanisms. Method 47 melanomas was assessed using...
Immune avoidance mechanisms play a key role in the successful dissemination of melanoma. One mechanism whereby this could be achieved is by interfering with dendritic cell (DC) presentation tumour-associated antigens to naïve T cells. In particular, immature DCs characterized absence accessory molecules are known immunosuppressive and involved induction tolerance. The present study has investigated presence activation status within melanoma metastases regional lymph nodes. Using image...
Imatinib mesylate is a specific inhibitor of the Bcr–Abl protein tyrosine kinase that competes with ATP for its binding site in domain. It has activity against platelet-derived growth factor receptor alpha and beta (PDGFR-α -β), c-kit, stem cell factor. We have used standardized ATP-tumor chemosensitivity assay immunohistochemistry to determine cytotoxicity imatinib tumor-derived cells from cutaneous uveal melanoma, ovarian carcinoma. was tested at concentrations ranging 2.0 0.0625 μmol/l...
A common unsatisfactory long-term outcome of otoplasty is undercorrection and residual deformity. Aggressive scoring with a scalpel blade can cause unattractive painful ridging, especially in older patients stiffer cartilage. We developed an ex vivo pig ear model to compare the effectiveness bipolar diathermy for cartilage warping. Strips harvested from Landrace ears were subjected (group A), B), combined reverse-side C). The strip deflection tension measured each group. No statistical...
Abstract Introduction The incidence of BIA-ALCL is on the rise. It a recognised rare risk breast implants. commonly presents with sudden, dramatic seroma around an implant, or occasionally mass. Diagnosis based cellular morphology and staining positive for CD30 negative anaplastic lymphoma kinase (ALK). aetiology management remains unclear. Clemens et al. suggest conventional Ann-Arbor staging system aggressive local systemic treatments may not be appropriate. In majority cases, confined to...
Journal Article Acute testicular torsion following orchidopexy for undescended testis Get access J S Hurren, Hurren Department of Surgery and Urology, Southampton General Hospital, Southampton, UK Correspondence to: Mr J. S. Plastic Surgery, Odstock Salisbury SP2 9BJ, Search other works by this author on: Oxford Academic Google Scholar A P Corder British Volume 79, Issue 12, December 1992, Page 1292, https://doi.org/10.1002/bjs.1800791215 Published: 08 2005 history Accepted: 17 July 1992
Sir: A common, unsatisfactory, long-term outcome of otoplasty is undercorrection and residual deformity,1,2 with the complication rate increasing postoperative time.3 Scoring cartilage to permanently alter its shape a well-established technique based on natural ability cartilage, stripped perichondrium, warp away from scored surface. Aggressive scoring can cause unattractive painful ridging may result in suture tension, undercorrection, recurrence. In older patients stiffer additional...
The use of a V-Y advancement flap for reconstruction volar/lateral soft tissue defect in digit involving segmental loss the neurovascular bundle up to 10 mm at middle phalangeal level is described. This allows immediate with primary repair nerve and gives good functional results. Two cases are presented.