A5040643779- Hippo pathway signaling and YAP/TAZ
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Cellular Mechanics and Interactions
- Cancer, Lipids, and Metabolism
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Immune Response and Inflammation
- Barrier Structure and Function Studies
- Air Quality Monitoring and Forecasting
- Genetic factors in colorectal cancer
- Genetics and Neurodevelopmental Disorders
- Wnt/β-catenin signaling in development and cancer
- Cancer Genomics and Diagnostics
- Cell death mechanisms and regulation
- Neurological diseases and metabolism
- Cancer-related gene regulation
- Molecular Biology Techniques and Applications
- Air Quality and Health Impacts
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Genomics and Rare Diseases
- Renal and related cancers
Shandong First Medical University
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2022
Penn State Milton S. Hershey Medical Center
2018-2021
Kaohsiung Medical University
2021
Hopp Children's Cancer Center Heidelberg
2019
Pennsylvania State University
2018
Institute of Medical Biology
2014
University of Electronic Science and Technology of China
2013
Abstract Tumor necrosis commonly exists and predicts poor prognoses in many cancers. Although it is thought to result from chronic ischemia, the underlying nature mechanisms driving involved cell death remain obscure. Here, we show that glioblastoma (GBM) involves neutrophil-triggered ferroptosis. In a hyperactivated transcriptional coactivator with PDZ-binding motif-driven GBM mouse model, neutrophils coincide temporally spatially. Neutrophil depletion dampens necrosis. Neutrophils isolated...
Abstract YAP1 fusion-positive supratentorial ependymomas predominantly occur in infants, but the molecular mechanisms of oncogenesis are unknown. Here we show YAP1-MAMLD1 fusions sufficient to drive malignant transformation mice, and resulting tumors share histo-molecular characteristics human ependymomas. Nuclear localization protein is mediated by MAMLD1 independent YAP1-Ser127 phosphorylation. Chromatin immunoprecipitation-sequencing analyses YAP1-MAMLD1-positive ependymoma reveal...
Intratumor heterogeneity associates with cancer progression and may account for a substantial portion of therapeutic resistance. Although extensive studies have focused on the origin heterogeneity, biological interactions between heterogeneous malignant cells within tumor are largely unexplored. Glioblastoma (GBM) is most aggressive primary brain tumor. Here, we found that expression Yes-associated protein (YAP, also known as YAP1) intratumorally in GBM. In xenograft mouse model,...
The Hippo pathway effector TAZ promotes cellular growth, survival, and stemness through regulating gene transcription. Recent studies suggest that liquid-liquid phase separation (LLPS) compartmentalizes key cofactors to activate However, how LLPS is achieved remains unknown. Here, it shown the paraspeckle protein NONO required for activation in nucleus. a TAZ-binding protein. Their interaction shows temporal regulation parallel between TEAD as well expression of target genes. depletion...
Exposure to airborne particulate matter (PM) is a major risk which increases pulmonary diseases such as asthma, chronic bronchitis, or obstructive disease (COPD). PM complex mixture with physiochemical properties that can vary over time and space, presenting challenge when attempting analyze their health risks. In this study, we compared two kinds of commercial real explore an index takes account both the diverse physicochemical accurate prediction toxicities. Our results indicated oxidative...
The traditional vaccine adjuvant research is mainly based on the trial and error method, mechanisms underlying immune system stimulation remaining largely unknown. We previously demonstrated that heparan sulfate (HS), a TLR-4 ligand endogenous danger signal, effectively enhanced humoral cellular responses in mice immunized by HBsAg. This study aimed to evaluate whether HS induces better against inactivated Hepatitis A or Rabies Vaccines, respectively, compared with adjuvants (e.g. Alum...
Background: Infantile hypotonia with psychomotor retardation and characteristic facies 2 (IHPRF2) is a rare autosomal recessive neurodevelopmental disorder caused by mutations in the UNC80 gene. It characterized severe global developmental delay, poor or absent speech limited walking abilities. The current study explored case of Chinese patient IHPRF2 novel splicing variant . Case Report: proband 8-year-old male manifested truncal hypotonia, intellectual disability. SNP array analysis...
Pantothenate kinase-associated neurodegeneration (PKAN) is a rare genetic neurodegenerative disorder with brain iron accumulation characterized as dysarthria, spasticity, cognitive impairment, parkinsonism, and retinopathy. PKAN caused by biallelic mutations in the mitochondrial pantothenate kinase 2 ( PANK2 ) gene. Herein, we report 4-year-old patient from Han Chinese family, who presented developmental regression, progressive inability to walk, limb tremors. Neuroimaging demonstrated...
Ependymoma (EPN) is one of the most aggressive pediatric brain tumors, often arising in supratentorial (ST) region. Our previous DNA methylation profiling study has identified ST-EPN subgroups that are characterized by YAP1-related fusions through genomic structural rearrangements (hereafter called as ST-EPN-YAP1). No reports amplification and hyper-activation YAP1 gene ST-EPN-YAP1s postulate could have unique oncogenic function(s) this type cancer. Nevertheless, lack adequate models for...
Abstract Tumor necrosis indicates poor prognoses in many cancers, including glioblastomas (GBMs). Although thought to result from chronic ischemia, the underlying nature and mechanisms driving involved cell death remain obscured by lack of animal models recapitulating extent human GBMs. The molecular clinical heterogeneity GBMs adds further complexity. Not all contain necrosis. Mesenchymal (MES)-GBM, subtype correlated with worst prognosis highest treatment resistance, is most closely...
Programming oriented on-machine examination (POME) faces some new cheating challenges.They exploit the features of third-party programming tools used in POME.Traditional methods, such as screen taking over, packet filtering, traditional system could not prevent based on tools, so they are useless POME.To address problems POME, an API hooking hybrid mechanism is proposed.By killing processes a black list and related APIs thirdparty can effectively decrease rates POME
Glioblastoma (GBM), the deadliest and most common primary CNS malignancy in adults, is highly heterogeneous with variable prognoses treatment responses. The molecular underpinnings for such variability remain largely unclear. Mesenchymal (MES)-GBMs, associated poorest prognosis highest resistance, exhibit hyperactivity of transcriptional coactivator PDZ-binding motif (TAZ), major effector Hippo tumor suppressive pathway. Additionally, microenvironment (TME) MES-GBMs appears to be altered,...
Abstract Glioblastoma (GBM), the deadliest and most common adult brain malignancy, is molecularly clinically heterogeneous. The subtype (both primary recurrent), mesenchymal (MES)-GBM, has worst prognosis highest treatment resistance. MES-GBM exhibits hyperactive transcriptional coactivator with PDZ-binding motif (TAZ), a Hippo tumor suppressive pathway effector whose expression in GBMs predicts short survival. Yet, how Hippo-TAZ dysregulation might drive GBM MES transition remains elusive,...
Abstract YAP1 fusion-positive supratentorial ependymomas predominantly occur in infants, but the molecular mechanisms of oncogenesis are unknown. Here we show YAP1-MAMLD1 fusions not wildtype sufficient to drive malignant transformation neural progenitors developing cerebral cortex mice, and resulting tumours share histo-molecular characteristics human ependymomas. Nuclear localization protein is associated with its oncogenicity mediated by nuclear signal MAMLD1 a YAP1-Ser127...
Abstract Glioblastoma (GBM), the deadliest and most common primary brain malignancy in adults, is highly heterogeneous with variable prognoses treatment responses. The mesenchymal subtype of GBM associated worst prognosis highest resistance. It still not clear how differentiation achieved. Hyperactivity transcriptional coactivator PDZ-binding motif (TAZ) was linked to transformation, although its role this process remains unclear. Here, by using orthotopic xenograft mouse models, we found...