A5005481304- Hemoglobinopathies and Related Disorders
- Erythrocyte Function and Pathophysiology
- Blood groups and transfusion
- Prenatal Screening and Diagnostics
- Viral Infectious Diseases and Gene Expression in Insects
- Rural and Ethnic Education
- Bone and Joint Diseases
- Chronic Lymphocytic Leukemia Research
- Science and Education Research
- Acute Myeloid Leukemia Research
- Glycogen Storage Diseases and Myoclonus
- Bacillus and Francisella bacterial research
- Digital Imaging for Blood Diseases
- vaccines and immunoinformatics approaches
- Iron Metabolism and Disorders
- Folate and B Vitamins Research
- CRISPR and Genetic Engineering
- CAR-T cell therapy research
- Growth Hormone and Insulin-like Growth Factors
- Virus-based gene therapy research
- SARS-CoV-2 and COVID-19 Research
Universidade de São Paulo
2020-2024
Universidade de Ribeirão Preto
2020-2023
Clinics Hospital of Ribeirão Preto
2022
From a country with one of the highest SARS-CoV-2 morbidity and mortality rates, Brazil has implemented most successful vaccination programs. Brazil’s first model city program was performed by CoronaVac vaccine (Sinovac Biotech) in town Serrana, São Paulo State. To evaluate effect on molecular dynamics clinical outcomes, we surveillance 4375 complete genomes obtained between June 2020 April 2022 this location. This study included period initial introduction during process. We observed that...
Bone marrow mesenchymal stromal cells (BM-MSCs) are key elements of the hematopoietic niche and participate in regulatory mechanisms stem (HSCs). Hematological diseases can affect MSCs their functions. However, dysregulations caused by sickle cell disease (SCD) not fully elucidated. This work explored changes BM-MSCs relationship with age using mice (Townes-SS). were isolated from Townes-SS, control groups 30- 60-day-old Townes-AA C57BL/6 J. The showed no morphological differences culture...
Abstract Currently, the majority of commercial recombinant therapeutic proteins are produced in nonhuman expression systems. Human cells capable producing with post‐translational modifications that more similar to native which reduce immunogenicity. This article describes potential human cell lines Sk‐Hep‐1, HKB‐11, and Huh‐7, cultured serum‐free suspension conditions, produce a complex glycoprotein, erythropoietin (EPO). Recombinant were generated by lentiviral transduction sorted flow...
Due to the challenges associated with accessing bone marrow samples from individuals sickle cell anemia (SCA), hematopoiesis in context of this disease remains less studied compared other pathologies. However, characterizing circulating hematopoietic stem and progenitor (HSPC) populations is feasible may provide insights into phenotype patients. Moreover, characterization HSPCs SCA, especially among patients under different treatment protocols, holds significant value perspective gene...
The characterization of beta globin (β-Hbb) gene haplotypes in sickle cell anemia patients continues to be a valuable source information for understanding the heterogeneity clinical manifestations this disease and regional global interpretation human migrations. In work, we performed main β-Hbb 327 from South, Midwest Southeast Brazil, applying multiplex system single nucleotide polymorphisms (SNP). addition, comparative historical investigation was carried out on distribution Brazil twelve...
A hidroxiureia (HU) é um medicamento que aumenta os níveis de hemoglobina fetal nos eritrócitos, diminuindo complicações clínicas como vasoclusão, hemólise e inflamação sistêmica associadas à anemia falciforme (AF). Contudo, a HU interfere em aspectos essenciais do nicho hematopoiético, proliferação, renovação diferenciação das células-tronco progenitoras hematopoéticas (CTPHs). Isso limita as perspectivas sucesso procedimentos o transplante terapia gênica, são únicas abordagens terapêuticas...
Purpose: Studying stress erythropoiesis (SE) in sickle cell anemia (SCA) is difficult because of the rigor accessing bone marrow samples. However, characterization circulating populations reflecting SE feasible and critical, especially perspectives gene therapy. Materials methods: Clinical laboratory data were collected from 49 subjects with SCA (SS-genotype) under chronic transfusion (CT, n = 15), hydroxyurea therapy (HC, 20), or both treatments (CT/HC, 14) at Blood Center Ribeirão Preto -...
A aloimunização eritrocitária é uma complicação grave relacionada à terapia transfusional de indivíduos com Doença Falciforme (DF). presença um estado pró-inflamatório precedendo a terapêutica transfusão pode ser fator relevante para o desenvolvimento anticorpos eritrocitários. Desta forma, identificar fatores preditivos e compreender as etapas do processo em pacientes DF ajudar no manejo desta doença outras que requerem transfusão. Neste trabalho investigamos possível associação...