A5065916792- Thyroid Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Growth Hormone and Insulin-like Growth Factors
- Regulation of Appetite and Obesity
- Genetic factors in colorectal cancer
- Neuroblastoma Research and Treatments
- Pituitary Gland Disorders and Treatments
- Thyroid Disorders and Treatments
- Ovarian cancer diagnosis and treatment
- Diabetes and associated disorders
- Adrenal Hormones and Disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Iron Metabolism and Disorders
- Obstructive Sleep Apnea Research
- Hypothalamic control of reproductive hormones
- Adipose Tissue and Metabolism
- GDF15 and Related Biomarkers
- Cancer-related Molecular Pathways
- BRCA gene mutations in cancer
- Venous Thromboembolism Diagnosis and Management
- Mitochondrial Function and Pathology
- Pancreatic function and diabetes
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Diet, Metabolism, and Disease
- Hormonal Regulation and Hypertension
Poznan University of Medical Sciences
2016-2025
Chromogranin A, despite a number of limitations, is still the most valuable marker neuroendocrine tumors (NETs).Granins belong to family acidic proteins that constitute major component secretory granules various endocrine and cells, which are components both classical glands diffuse system.These cells potential source transformation into tumors.The awareness causes influencing false results its concentrations simplifies diagnosis treatment.One disadvantages this non-specificity existence...
The vast majority of breast cancer patients require radiotherapy but some them will develop local recurrences and potentially metastases in the future. Recent data show that exosomal cargo is essential these processes. Thus, we investigated influence ionising radiation on exosome properties their ability to modify sensitivity biology non-irradiated cells. Exosomes were isolated from cell lines (MDA-MB-231, MCF7, SKBR3) irradiated with 2 Gy (Exo Gy) or no irradiation 0 Gy). Despite...
Introduction: Irisin, a cleaved and secreted part of the transmembrane protein FNDC5, is recently discovered adipo-myokine that said to have significant influence on body metabolism. Changes in thyrometabolic state may also alter serum irisin level. Since already reported data are not fully consistent, aim present research evaluate time-dependent changes level patients affected by overt hypothyroidism. Material methods: The study involved 36 subjects — two groups 12 with long-lasting (AITD)...
Gastroenteropancreatic neuroendocrine tumors (GEP/NET) are unusual and rare neoplasms that present many clinical challenges. They characteristically synthesize store secrete a variety of peptides neuroamines which can lead to the development distinct syndrome, however clinically silent until late presentation with mass effects. Management strategies include surgery cure cytoreduction use somatostatin analogues. Somatostatin have broad range biological actions inhibition exocrine endocrine...
Thyroid cancer incidence has increased significantly during the past decades and is most common type of endocrine malignancy. Many factors in thyroid cancers were studied as independent predictors a poor prognosis.The objective study was to evaluate survivin expression - BIRC5 its splice variants: delta Ex3 2B benign malignant nodules.Thyroid tissues samples from group 50 patients consisting of: 29 with (including medullary, papillary, follicular undifferentiated types), well 21...
Type 1 diabetes mellitus (T1DM) is associated with chronic complications, which are the result of neurovascular changes. There still a lack universal biochemical markers microvascular damage. The present study aimed to investigate whether selected inflammatory proteins related prevalence complications in adult T1DM patients. following were determined group 100 participants: epidermal growth factor (EGF), metalloproteinase 2 (MMP-2), growth/differentiation 15 (GDF-15), and interleukin 29...
Background: The mutation frequencies of pituitary transcription factors genes in patients with combined hormone deficiencies (CPHD) vary substantially between populations. However, apart from PROP1 the rate other is low and for almost half CPHD routine sequencing known unsuccessful identification genetic causes. Methods: A cohort 66 sporadic 9 familial cases (80 total) were subjected to initial testing PROP1, POU1F1, LHX3, LHX4 HESX1 using a targeted gene panel MLPA. In who tested negative,...
Abstract The purpose of the study was to measure hepcidin concentration and evaluate Fe homeostasis indices in a prospective on patients with newly diagnosed hypothyroidism course Hashimoto’s thyroiditis (HT) following successful therapy. observational consisted 34 patients. clinical evaluation laboratory tests were performed at diagnosis (T0) after restoration euthyreosis 12 weeks later (T1). median level significantly lower (p = 0.002) recovery (7.7 [6.2–13.0] ng/mL) than that before...
Normosmic isolated hypogonadotropic hypogonadism (nIHH) is a clinically and genetically heterogeneous disorder. Deleterious variants in over 50 genes have been implicated the etiology of IHH, which also indicates possible role digenicity oligogenicity. Both classes controlling GnRH neuron migration/development hypothalamic/pituitary signaling development are strongly nIHH pathogenesis. The study aimed to investigate genetic background further expand genotype-phenotype correlation.
Hepcidin is an acute-phase protein involved also in regulation of iron homeostasis. The aim the study was to prospectively assess for first time hepcidinEL concentration patients with subacute thyroiditis (SAT), identify biochemical determinants and evaluate potential role hepcidin SAT diagnosis monitoring.Out 40 initially recruited, restrictive inclusion criteria fulfilled 21 subjects aged 45 ± 10 years healthy control (CS). HepcidinEL concentration, thyroid status, homeostasis were...
The role of genetic background in childhood-onset combined pituitary hormone deficiency (CPHD) has been extensively studied. major contributors are the PROP1, POU1F1, LHX3, LHX4 and HESX1 genes coding transcription factors implicated organogenesis. clinical consequences mutations encompass impaired synthesis a growth (GH) one or more concurrent hormones (i.e. LH, FSH, TSH, PRL). Manifestation disorder may vary due to various mutation impacts on final gene products an influence environmental...
Kallmann syndrome (KS) is a combination of isolated hypogonadotropic hypogonadism (IHH) with olfactory dysfunction, representing heterogeneous disorder broad phenotypic spectrum. The genetic background KS has not yet been fully established. This study was conducted on 46 Polish subjects (41 males, 5 females; average age: 29 years old). studied patients were screened for defects in 38-gene panel next-generation sequencing (NGS) technology. analysis revealed 27 pathogenic and likely (P/LP)...
Pre- and postsurgical differentiation between follicular thyroid adenoma (FTA) cancer (FTC) represents a significant diagnostic challenge. Furthermore, it remains unclear whether they share common or distinct background what the mechanisms underlying lesions malignancy are. The study aimed to compare FTA FTC by comprehensive microarray identify recurrent regions of loss heterozygosity (LOH). We analyzed formalin-fixed paraffin-embedded (FFPE) samples acquired from 32 Caucasian patients...
Inconclusive cytologic results of thyroid fine‑needle aspiration biopsy (FNAB) include atypia or follicular lesion undetermined significance (FLUS) and neoplasm suspicious for (SFN).We aimed to assess the genetic background indeterminate nodules identify new pathways potentially involved in development cancer.Genomic DNA was isolated from FNAB samples 25 white patients (2 men; 23 women) diagnosed preoperatively with FLUS (n = 16) SFN 9). Next‑generation sequencing (NGS) performed. The were...
Introduction Adipokines are signaling molecules involved in the integration of metabolism. Changes their concentrations were observed obesity, metabolic syndrome, diabetes mellitus and cardiovascular diseases, as well endocrine disorders. Cushing’s syndrome is associated with dysregulation, but significance adipokines this entity related complications largely unknown. The aim our study was to determine adipokines: fetuin A, fatty acid binding protein 4 (FABP4) retinol (RBP4) assess relation...
Ovarian cancer is the eighth most common and seventh highest cause of cancer‑associated mortality in women worldwide. It second among female reproductive malignancies. The current standard first‑line treatment for advanced ovarian includes a combination surgical debulking systemic platinum‑based chemotherapy with carboplatin paclitaxel. Although deeper understanding this disease has been attained, relapse occurs 70% patients 18 months subsequent to treatment. Therefore, it crucial develop...
Interleukins play an important role in the development of autoimmune disorders. The aim this study was to compare concentration interleukin-29 (IL-29) between healthy controls (CS) and patients with selected thyroid disorders: Graves' disease (GD), Hashimoto's thyroiditis (HT) subacute (SAT).The following parameters were examined group 95 individuals (45 GD, 22 HT, 28 SAT) 72 CS: hormones autoantibodies, inflammatory markers IL-29 serum.The GD subgroup higher than that CS [264.0...
Introduction Thyroid nodular goiter is one of the most common medical conditions affecting even over a half adult population. The risk malignancy rather small but noticeable–estimated by numerous studies to be about 3–10%. definite differentiation between benign and malignant ones vital issue in endocrine practice. aim current study was assess expression vascular endothelial growth factor A (VEGF-A) VEGF-C on mRNA level FNAB washouts case thyroid nodules evaluate diagnostic value these...
The role of autoimmunization in the pathogenesis pituitary disorders is poorly understood. presence autoantibodies (APA) has been detected various disorders. Their role, however, remains elusive. Childhood-onset combined hormone deficiency (CPHD) may be caused by environmental or genetic factors. In some patients, causes disease remain unclear and contributions autoimmune processes have postulated. aim this study was to identify microsomes-derived antigens (MPA) as potential immunogenic...