A5065440554- Cancer, Lipids, and Metabolism
- Single-cell and spatial transcriptomics
- Cancer, Hypoxia, and Metabolism
- Skin Protection and Aging
- Mitochondrial Function and Pathology
- Clusterin in disease pathology
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- S100 Proteins and Annexins
- Cutaneous Melanoma Detection and Management
- RNA Research and Splicing
- Biomarkers in Disease Mechanisms
- Sirtuins and Resveratrol in Medicine
Seoul National University
2022-2023
Metabolic dysregulation is an important hallmark of cancer. Nicotinamide (NAM), a water‐soluble amide form niacin (vitamin B3), currently available as supplement for maintaining general physiologic functions. NAM crucial regulator mitochondrial metabolism and redox reactions. In this study, we aimed to identify the mechanistic link between NAM‐induced metabolic regulation therapeutic efficacy in triple‐negative breast cancer (TNBC). The combined analysis using multiomics systems biology...
Abstract Diabetes mellitus (DM) is a chronic metabolic disorder characterized by inappropriate hyperglycemia, which causes endothelial dysfunction and peripheral neuropathy, ultimately leading to multiple complications. One prevalent complication diabetic erectile (ED), more severe resistant treatment than nondiabetic ED. The serum glycoprotein leucine-rich ɑ-2-glycoprotein 1 (LRG1) modulator of TGF-β-mediated angiogenesis has been proposed as biomarker for variety diseases, including DM....
Abstract Aging is a major driver of diseases in humans. Identifying features associated with aging essential for designing robust intervention strategies and discovering novel biomarkers aging. Extensive studies at both the molecular organ/whole-body physiological scales have helped determined However, lack meso-scale studies, particularly tissue level, limits ability to translate findings made scale impaired functions In this work, we established image analysis workflow - quantitative...