A5040215530- Cytomegalovirus and herpesvirus research
- Parvovirus B19 Infection Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis C virus research
- Herpesvirus Infections and Treatments
- Infectious Encephalopathies and Encephalitis
- Human Health and Disease
- Toxoplasma gondii Research Studies
- Liver Diseases and Immunity
- COVID-19 Impact on Reproduction
- Immunodeficiency and Autoimmune Disorders
- Maternal and fetal healthcare
- Medical Coding and Health Information
- Discourse Analysis and Cultural Communication
- Prenatal Screening and Diagnostics
- Legionella and Acanthamoeba research
- Ethics in Clinical Research
- Hepatitis B Virus Studies
- Viral Infections and Vectors
- Diabetes and associated disorders
- Biomedical and Engineering Education
- Literature Analysis and Criticism
- Health and Medical Research Impacts
- Science, Research, and Medicine
Federal Medical-Biological Agency
2020-2025
Children's Scientific and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency
2022-2023
Saint Petersburg State Pediatric Medical University
2014-2022
Infectious Clinical Hospital No. 1
2019
Scientific Center of Children's Health
2014
BACKGROUND: Currently, research investigating specific immunity to various TORCH pathogens (Toxoplasma gondii, cytomegalovirus, rubella virus) in pregnant women remains relevant. AIM: The aim of the study was evaluate detection rates main serologic markers Saint Petersburg, Russia. METHODS: A retrospective analysis screening (n = 6605) performed for presence and levels anti-Toxoplasma anti-rubella, anti-cytomegalovirus immunoglobulins M G blood. RESULTS: seroprevalence rate 98.2% 4428), with...
The authors present modern epidemiological data and features of the etiopathogenesis metabolically associated fatty liver disease in children (non-alcoholic disease), provide clinical characteristics various variants this nosology. Information is provided on laboratory, instrumental morphological signs children, as well methods prevention, treatment rehabilitation accordance with developed guidelines.
Russia has one of the highest prevalences paediatric chronic hepatitis C infection (CHC). Our aim was to provide a detailed characterization children and adolescents with CHC including treatment outcomes. Thus, an observational study aged <18 years conducted in three hepatology centres from November 2014 May 2017. Of 301 (52% male), 196 (65%) acquired HCV vertically, 70 (23%) had history blood transfusion or invasive procedures, 1 injecting drug use 34 (11%) no known risk factors. Median age...
Timely diagnostics and treatment of cytomegalovirus infection in pregnant women newborns allow to avoid serious consequences, preserving the life health child. The article provides an example antenatal diagnosis congenital fetus (positive result polymerase chain reaction umbilical cord blood), with transfusion donor red blood cells, postnatal therapy antiviral drugs, including ganciclovir specific immunoglobulin. issues assessing risk infection, approaches its prevention during pregnancy are...
The formation of biobanks in the structure scientific and treatment diagnostic institutions with prospects for interregional integration is a fundamental link monitoring predicting diseases various origins, creating testing highly effective diagnostics, developing novel therapeutic agents. Aim . To describe standard operating procedures principles bioresource collections (BRC) medical biobanking. Material methods data practical biomedical projects using BRC obtained from patients genetic,...
The aim of the study: to establish rate vertical transmission HCV infection and justify usefulness drug a-IFN2b (Viferon®) in children with perinatal hepatitis C virus (HCV) at early stages disease. There were examined 465 aged 2.5 months 3 years old (at time enrollment study), born mothers frequency from mother child was established be is 7.1% (33 cases). In 54.5% genotype 1b recorded, 3% - 1a, 6.0 % 2 genotype. Viferon® doses 3х10 6IU/m introduced 17 infants 12 (duration course: 6 cases 3,...
The problem of cytomegalovirus infection (CMVI) in children is caused by its ubiquitous spread, polymorphism clinical manifestations, which depends on the state human immune system. article presents cases CMVI, demonstrating possibility developing a different variant course acquired CMVI same family. first case demonstrates severe CMV patient 1 year 6 months old, hospitalized late disease (day 8 disease). peculiarity this development generalized form child against background...
The need for early diagnosis of congenital infections is due to the high incidence morbidity and mortality in neonatal period. Morphological study placenta has great practical value fetuses. It allows optimizing supervision newborns preventing development severe perinatal complications. Comprehensive assessment course pregnancy combination with morphological examination are important predicting condition newborns, formation risk groups, prevention treatment children. In case antenatal death...
Among the classic pathogens of congenital infection, herpes simplex viruses type 1 and 2 play important role. Neonatal develops as a result antenatal transmission HSV. The greatest risk occurs with primary infection woman in late stages pregnancy. In 85% cases, genital neonatal is associated HSV-2. purpose study: to identify relationship between early manifestations during pregnancy for diagnosis etiological therapy newborn. Materials methods. analysis current clinical recommendations...
Cytomegalovirus infection (CMVI) is a common viral disease. Differential diagnosis of congenital and acquired forms the disease in infants rather difficult. The purpose this research was to describe cytomegalovirus clinical features depending on management tactics. Materials methods used: а retrospective study 95 medical records pediatric patients treated for CMVI their first year life. 3 groups were formed as follows: G1 40 with confirmed CMVI, G2 (43) an assumed G3 (12) (the comparison...
Objective of the research – to create algorithms for observation children with some congenital infectious diseases (CID) in outpatient clinics on basis author's own experience and existing clinical guidelines analysis. The article presents parametric non-parametric statistical analysis of data base survey results, treatment more than 800 CID, identified among those who came consultation at Research Institute Children's Infections, treated other health care institutions city 2010–2016....
Congenital viral infectious diseases are characterized by polyetiologic pathology holding an important place in the structure of perinatal losses. Due to wide distribution and lack specific prophylaxis, problem herpesvirus infections is greatest interest, namely herpes infection caused simplex virus type 1 2, human 6 cytomegalovirus infection, as well parvovirus B19. The opportunities investigate a relation between manifestations process host molecular genetic characteristics have been...
This review presents the current possibilities of diagnosis of children’s liver disease: to define avidity antibodies to hepatitis A, C for detection early infection, development of non-invasive panel serum markers fibrosis and introduction elastography liver, as an alternative to needle biopsy. Indicated promising directions in therapeutic tactics viral children associated with the use combined schemes parenteral interferon (IF), including pegylated, conjunction with similar...
We have performed primary examination of 50 children with neonatal hepatitis. Prevalence of herpes infection as the etiologic agent (40,0%) has been found, as well parenteral hepatitis, both an isolated (26,0%) and mixed infections. conducted a comparative analysis of clinical and laboratory data at initial determined the outcomes hepatitis to 12 months of life depending on etiology. Congenital CMV- etiology hepatitis characterized by more cytolysis, mainly due aspartate aminotransferase...
Recently the actual direction is development of programs rehabilitation second stage recovering infectious diseases children. The purpose this work justification need organization offices in a children's hospital according to Order medical rehabilitation. retrospective analysis clinical records patients who have arrived on treatment divisions Federal State Budgetary Institution Research Children's Infections Russia 2011—2012 carried out. It established, that among surveyed 14 363 for 2 years...
The review presents modern information of domestic and foreign authors about possible pathogenetic mechanisms the virus effect on fetus in case cytomegalovirus infection pregnant women. Immunosuppressive changes, which are a feature physiological course pregnancy, create favorable conditions for development active infection. virus’s ability to infect wide range cells vivo trigger set molecular causes changes placental cell differentiation, plays key role transplant transmission. processes...
РУБРИКА ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ Поражения органов и систем у детей, родившихся от матерей с острой цитомегаловирусной инфекцией1 Федеральное государственное бюджетное учреждение «Детский научно-клинический центр инфекционных болезней» Федерального медико-биологического агентства России, 197022, г
Congenital toxoplasmosis is a consequence of acute in pregnant woman. When assessing the risk сongenital during pregnancy, methods for determining specific antibodies, genetic material pathogen (polymerase chain reaction method), immunoglobulins G avidity are used. Molecular have greatest diagnostic value diagnosis children first year life. Drug prevention Russia can be implemented with use spiramycin, antenatal therapy impossible, and postnatal limited by list available antiprotozoal drugs....