A5090272790- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Neuroscience of respiration and sleep
- Cardiac Arrest and Resuscitation
- EEG and Brain-Computer Interfaces
- Optical Imaging and Spectroscopy Techniques
- Sleep and Wakefulness Research
- Cardiac Ischemia and Reperfusion
- Neuroscience and Neuropharmacology Research
- Cardiac electrophysiology and arrhythmias
- Neuroinflammation and Neurodegeneration Mechanisms
- Atomic and Subatomic Physics Research
- Nitric Oxide and Endothelin Effects
Washington University in St. Louis
2021-2025
Regional blood flow within the brain is tightly coupled to regional neuronal activity, a process known as neurovascular coupling (NVC). In this study, we demonstrate striking role of SUR2- and Kir6.1-dependent ATP-sensitive potassium (KATP) channels in control NVC sensory cortex conscious mice, response mechanical stimuli. We that either globally increased (pinacidil-activated) or decreased (glibenclamide-inhibited) KATP activity markedly disrupts NVC; pinacidil-activation capable completely...
Neural activity in the delta range (1.0-4.5 Hz) during non-rapid eye movement (NREM) sleep is crucial for brain plasticity and overall health. Recent research has shown that changes NREM can occur locally, vary across different regions. Ischemic stroke results focal injury long-term disability. While disruption acute phase of known to hinder recovery, relationship between region-specific functional recovery remains poorly understood. To investigate these localized with high spatial...
Significance Slow waves are the predominant feature of brain activity during sleep and anesthesia. associated with plasticity, memory consolidation, other functions. However, much remains unknown about circuits that coordinate slow wave propagation. Here, we demonstrate somatosensory stimulation evokes bilateral activation primary cortices (S1). Under anesthesia, S1 is followed by a global, front-to-back cortical wave. Using focal lesion model, show evoked global depend on activation,...
Stroke is the leading cause of chronic disability in United States. How stroke size affects post-stroke repair and recovery poorly understood. We aim to investigate effects on early patterns determine how changes neuronal circuits networks predict functional outcomes after stroke. used wide-field optical imaging, photothrombosis, cylinder-rearing assay examine circuit network activity context Larger strokes ablating S1FP caused diffuse widespread forepaw stimulus-evoked cortical activation,...