A5075646991- Spectroscopy Techniques in Biomedical and Chemical Research
- Field-Flow Fractionation Techniques
- Enzyme Catalysis and Immobilization
- Analytical Chemistry and Chromatography
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Pesticide Residue Analysis and Safety
- Cholinesterase and Neurodegenerative Diseases
- thermodynamics and calorimetric analyses
- Parkinson's Disease Mechanisms and Treatments
- Advancements in Transdermal Drug Delivery
Lomonosov Moscow State University
2021-2024
The cutaneous delivery route currently accounts for almost 10% of all administered drugs and it is becoming more common. Chemical penetration enhancers (CPEs) increase the transport across skin layers by different mechanisms that depend on chemical nature enhancers. In our work, we created a enhancer database (CPE-DB) is, to best knowledge, first CPE database. We collected information about known their derivatives in single database, classified characterized molecular diversity terms...
Monoamine oxidase B (MAO-B) inhibitors are widely used as part of combination drug therapy for Parkinson’s disease. As demonstrated in both vitro and vivo experiments, the monoterpenoid Prottremine some its derivatives exhibit high antiparkinsonian activity. In this study, inhibitory activity (including 14 new 9-N- S-derivatives) against MAO-A MAO-B enzymes has been investigated first time. Compounds containing fragments substituted anilines have highest MAO-A; example, compound 28 had an...
Methylene blue has multiple antiviral properties against Severe Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2). The ability of methylene to inhibit different stages the virus life cycle, both in light-independent and photodynamic processes, is used clinical practice. At same time, molecular aspects interactions with components coronaviruses are not fully understood. Here, we use Brownian dynamics identify binding sites on SARS-CoV-2 envelope. local lipid protein composition...
The Brownian dynamics method can give insight into the initial stages of interaction antiviral drug molecules with structural components bacteria or viruses. RAM conventional personal computer allows calculation drugs individual coronavirus S protein. However, scaling up this approach for modeling whole virion consisting thousands proteins and lipids is difficult due to high requirements computing resources. In case method, main amount in calculations occupied by an array values...