Lipedema is an adipose tissue disorder characterized by the disproportionate increase of subcutaneous fat in lower and/or upper extremities. The underlying pathomechanism remains unclear and no molecular biomarkers to distinguish disease exist, leading a large number undiagnosed misdiagnosed patients. To unravel distinct characteristic lipedema we performed lipidomic analysis serum versus anatomically- body mass index (BMI)-matched control Both groups showed significant changes regarding...

Abstract Severe burn injuries present significant global healthcare challenges, with outcomes significantly influenced by factors such as socioeconomic status, mental health conditions, and substance use, which vary across regions systems. This study investigates the etiologies, treatment outcomes, impact of psychiatric conditions controlled use on in patients admitted to intensive care unit at Switzerland’s largest Burn Center. Data were retrospectively analyzed from 438 University Hospital...

Abstract Introduction Botulinum toxin A (BoTA) is a neurotoxin formed by Clostridium botulinum, with broad medical application spectrum. While the primary effect of BoTA on muscles, effects in other systems including blood vasculature have already been examined, revealing unexpected actions. However, no studies exist to best our knowledge regarding potential lymphatic vascular system, possessing critical role health and disease. Isolated human endothelial cells (LECs) were cultured dedicated...

Burn wounds pose significant challenges in medical treatment due to their devastating nature and resource-intensive requirements. Temporary coverage of burn using synthetic or biological dressings allows for reepithelization before definitive skin grafting. Allogenic grafts have been widely used but come with drawbacks such as rejection disease transmission. The use amniotic membranes (AMs) offers a promising alternative temporary coverage, they possess properties that promote faster healing...

Lipedema is a chronic disorder that mainly affects women. It often misdiagnosed, and its etiology remains unknown. Recent research indicates an accumulation of macrophages shift in macrophage polarization lipedema. One known protein superfamily contributes to the migration inhibitory factor (MIF) family. MIF-1 MIF-2 are ubiquitously expressed also regulate inflammatory processes adipose tissue. In this study, expression MIF-1, CD74-a common receptor for both cytokines-was analyzed tissue...

As the prevalence of juvenile-onset obesity rises globally, multitude related health consequences gain significant importance. In this context, is associated with impaired cutaneous wound healing. experimental settings, mice are most frequently used model for investigating effect high-fat diet (HFD) chow on healing in wild-type or genetically manipulated animals, e.g., diabetic ob/ob and db/db mice. However, these studies have mainly been performed adult animals. Thus, present study, we...

Abstract BCOR -rearranged sarcomas are rare and belong to the Ewing-like (ELS). Their morphology histopathological features make diagnosis challenging. We present a case, initially diagnosed as an unusual extraskeletal myxoid chondrosarcoma (EMC). A 54-year-old male patient developed asymptomatic swelling of lower leg. Imaging showed 9.5-cm large intramuscular soft tissue mass. Due its morphological immunohistochemical profile on biopsy, it was EMC. The treated by complete resection adjuvant...

Mechanically processed stromal vascular fraction (mSVF) is a promising source for regenerative purposes. To study the in vivo fate of mSVF, we herein used vascularized tissue engineering chamber that insulates target mSVF from surrounding environment. In contrast to previous models, propose an arteriovenous (AV) shunt between saphenous vessels rats without venous graft. Mechanical SVF was fat pads male Sprague Dawley rats, mixed with fibrin hydrogel and implanted into inguinal chamber. An...

Abstract Rationale: Degloving foot injuries are challenging to treat and associated with life-long sequelae for patients. An appropriate debridement of ischemic soft tissues maximal preservation glabrous skin is key during the reconstruction these injuries. Indocyanine green (ICG) fluorescence angiography an established technique intraoperative evaluation tissue perfusion. Patient concerns: Two patients sustained complex in traffic accidents, including multiple fracture dislocations...

The face is commonly affected in thermal injuries, with a demand for proper recognition and the correct choice of treatment to guarantee optimal aesthetic functional outcomes. It highly vascularized often heals conservatively, highlighting particular relevance conservative modalities, many which require daily re-applications or dressing changes, can be painful tedious both patient healthcare providers. Motivated by encouraging results novel temporary nanofibrous epidermal layer, we herein...

Mechanically processed stromal vascular fraction (mSVF) is a highly interesting cell source for regenerative purposes, including wound healing, and practical alternative to enzymatically isolated SVF. In the clinical context, SVF benefits from scaffolds that facilitate viability other cellular properties. present work, feasibility of methacrylated gelatin (GelMA), stiffness-tunable, light-inducible hydrogel with high biocompatibility investigated as scaffold in an vitro setting....

An 85-year-old male was hospitalized because of deterioration his general condition and infection the tracheostoma. He had laryngectomy, bilateral neck dissection radiation therapy for a laryngeal carcinoma 5 years earlier. Despite good recovery, he could not get up new onset postural symptoms (dizziness, lightheadedness, collapse). Late baroreflex failure autonomic nervous system were diagnosed. Volatility blood pressure (supine hypertension, upright hypotension) treated with NaCl...

Introduction: Progressive hemifacial atrophy (PHA) and linear scleroderma (LS) are both rare conditions defined by and/or sclerosis of the skin subcutaneous tissue. The ideal timing reconstructive intervention in these patients is controversial. We compared outcome satisfaction autologous lipofilling performed during active stable phases diseases adults. Methods: A retrospective chart review was conducted with all diagnosed PHA or LS between 2007 2019 our department. analysed demographic...

Correction of a boutonnière deformity is one the most demanding challenges in hand surgery. Surgical interventions are usually considered when functional use finger cannot be obtained after intense therapy. The authors introduce their newly described lambda (λ) repair, which an easy-to-learn, straightforward surgical technique. method involves end-to-side tenorrhaphy lateral bands, resembling Greek λ. Patients who underwent repair were retrospectively evaluated with preoperative and...

The regenerative potential of adipose-derived stromal cells (ASCs) has gained significant attention in and translational research. In the past, extraction these from adipose tissue required a multistep enzyme-based process, resulting heterogenous cell mix consisting ACSs other cells, which are jointly termed vascular fraction (SVF). More recently introduced mechanical SVF (mSVF) isolation protocols less time-consuming bypass regulatory concerns. We proposed protocol that generates mSVF rich...

Extradigital localizations of glomus tumors (GTs) remain rare and can often lead to missed or delayed diagnosis due nonspecific symptoms. In this article, we report a case GT with localization in the proximal third lower leg.