A5049933450- Entomopathogenic Microorganisms in Pest Control
- Insect Resistance and Genetics
- Insect Pest Control Strategies
- Insect and Pesticide Research
- SARS-CoV-2 and COVID-19 Research
- Insect Utilization and Effects
- Animal Virus Infections Studies
- SARS-CoV-2 detection and testing
- Insect symbiosis and bacterial influences
- Vector-borne infectious diseases
- Antibiotic Resistance in Bacteria
- Bird parasitology and diseases
- Research on Leishmaniasis Studies
- Nematode management and characterization studies
- Dermatological diseases and infestations
- Antibiotics Pharmacokinetics and Efficacy
- Forest Insect Ecology and Management
- Fungal Biology and Applications
- Drug Transport and Resistance Mechanisms
- vaccines and immunoinformatics approaches
- Antifungal resistance and susceptibility
- Study of Mite Species
- HIV/AIDS drug development and treatment
- Vitamin D Research Studies
- Natural product bioactivities and synthesis
Lebanese American University
2021-2025
École Nationale Vétérinaire d'Alfort
2019-2021
Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail
2019-2021
Université Paris-Est Créteil
2019-2020
Holy Spirit University of Kaslik
2019-2020
Lebanese Agricultural Research Institute
2019
Antimicrobial resistance (AMR), together with multidrug (MDR), mainly among Gram-negative bacteria, has been on the rise. Colistin (polymyxin E) remains one of primary available last resorts to treat infections caused by MDR bacteria during rapid emergence global resistance. As exact mechanism bacterial colistin undetermined, this study warranted elucidation underlying mechanisms and heteroresistance carbapenem-resistant Klebsiella pneumoniae isolates.
Abstract Halzoun syndrome is a rare parasitic infection associated with the consumption of raw liver, predominantly reported in Eastern Mediterranean. The condition presents significant diagnostic challenges due to its symptom overlap other and allergic disorders. We identified four cases family from North Bekaa region Lebanon. A detailed examination goat liver was conducted, followed by molecular characterisation using ITS‐2 phylogenetic analysis establish relationship local isolates...
Abstract The entomopathogenic fungi Beauveria bassiana (Balsamo) Vuillemin is known to produce a broad range of secondary metabolites. Beauvericin, cyclic hexadepsipeptide, the best mycotoxin produced by B. ; however, reports discussing insecticidal activity beauvericin per se are limited. In this study, we assessed lethal against Tetranychus urticae Koch (Acarina: Tetranychidae). addition, screening for suitable application T. on greenhouse strawberries discussed. Beauvericin was able...
Genomic surveillance of SARS-CoV-2 is critical in monitoring viral lineages. Available data reveal a significant gap between low- and middle-income countries the rest world.
Scabies is a frequent cutaneous infection caused by the mite Sarcoptes scabiei in large number of mammals, including humans. As resistance S. against several chemical acaricides has been previously documented, establishment alternative and effective control molecules required. In this study, potential acaricidal activity beauvericin was assessed different life stages var. suis comparison with dimpylate ivermectin, two commercially available used for treatment animals and/or
Abstract Multi-drug resistance is posing major challenges in suppressing the population of pests. Many herbivores develop resistance, causing a prolonged survival after exposure to previously effective pesticide. Consequently, resistant pests reduce yield agricultural production, significant economic losses and reducing food security. Therefore, overpowering acquisition crop must. The ATP binding cassette transporters (ABC transporters) are considered as main participants pesticide efflux...
ABSTRACT Leishmaniasis is a neglected tropical disease infecting the world’s poorest populations. Miltefosine (ML) remains primary oral drug against cutaneous form of leishmaniasis. The ATP-binding cassette (ABC) transporters are key players in xenobiotic efflux, and their inhibition could enhance therapeutic index. In this study, ability beauvericin (BEA) to overcome ABC transporter-mediated resistance Leishmania tropica ML was assessed. addition, transcription profile genes involved...
Drug discovery was initially attributed to coincidence or experimental research. Historically, the traditional approaches were complex, lengthy, and expensive, entailing costly random screening of synthesized compounds natural products coupled with in vivo validation largely depending on availability appropriate animal models. Currently, silico modeling has become a vital tool for drug repurposing. Molecular docking dynamic simulations are being used find best match between ligand molecule,...
Mediterranean stone pine nut is appreciated for its high economic and nutritional value. Starting in 2012, Pinus pinea production declined throughout the area. The dry cone syndrome associated with this decline introduction of Leptoglossus occidentalis occurred simultaneously. This study aims to evaluate potential reasons behind Lebanon, considering climatic factors invasion L. occidentalis. Correlation analysis was used examine a relationship between yield percentage damaged seeds per cone....
Establishing and maintaining tick colonies in the laboratory is essential for studying their biology pathogen transmission, or development of new control methods. Due to requirement very high humidity, these laboratory-bred are frequently subject fungal contamination. In present study, we aimed identify species that contaminated a laboratory-reared colony Ixodes ricinus through microscopic observation molecular identification. We identified three different taxa isolated from ticks:...
Early SARS-CoV-2 variant detection relies on testing and genomic surveillance. The Omicron (B.1.1.529) has quickly become the dominant type among previous circulating variants worldwide. Several subvariants have emerged exhibiting greater infectivity immune evasion. In this study we aimed at studying prevalence of during flu season beyond in Lebanon through screening determining overall standing trajectory pandemic country.
Leishmaniasis is a neglected disease and public health concern. Chemotherapeutic agents available for the treatment of parasitic infections, including leishmaniasis, have several limitations. For that, we designed highly sensitive assay using RT-aqPCR to evaluate efficacy antileishmanial drugs SYBR Green quantify expression marker genes. A matrix reactions different annealing temperatures primer concentrations was tested obtain optimum performance. The standard curves quantification...
The virulence of aerial conidia the entomopathogenic fungi Beauveria bassiana (Balsamo-Crivelli) Vuillemin (Hypocreales: Cordycipitaceae) has been documented on a very broad range arthropods; however, activity blastospores against two-spotted spider mite seldomly reported. Moreover, studies investigating under greenhouse conditions were not found in literature. In this study, we tested efficacy and two B. strains, all life stages Tetranychus urticae Koch (Acari: Tetranychidae). concentration...
The cedar forests of Lebanon have been threatened by the outbreak caused climate change a web-spinning sawfly,
Background. Tuberculosis is a pressing public health issue in Lebanon, country of approximately five million people, including around 1.5 refugees from Palestine and Syria. Prior research has revealed uncontrolled animal sources Mycobacterium bovis, emphasizing the necessity for comprehensive approach to combat tuberculosis region. Methods. 48 clinical complex isolates were identified through whole genome sequence. Also, 43 fecal samples collected various farms across Lebanon investigate...
Beauveria bassiana , a necrotrophic fungus thriving in diverse ecosystems, predominantly on arthropods, holds significant importance as biological agent. The escalating relevance of genetic studies fungi necessitates the development efficient and robust DNA extraction techniques to ensure acquisition high-quality DNA. B. was cultured produce either mycelia or blastospores. Six procedures two pre-treatment conditions were independently adopted evaluate their efficacy obtaining high molecular...
One of the most challenging issues scientists face is finding a suitable non-invasive treatment for cancer, as it widespread around world. The efficacy phytochemicals that target oncogenic pathways appears to be quite promising and has gained attention over past few years. We investigated effect docking isolated from rhizomes Cimicifuga foetida plant on different domains IκB kinase alpha (IKK1/alpha) protein. Cimicifugoside H-2 phytochemical registered high score activation loop IKK1/alpha...
Abstract Antimicrobial resistance (AMR), together with extensively drug resistant (XDR), mainly among Gram-negative bacteria, has been on the rise. Colistin (polymyxin E) remains one of primary available last resorts to treat infections by XDR bacteria rapid emergence global resistance. Since exact mechanism bacterial colistin unfolded, this study warranted elucidating underlying and heteroresistance carbapenem-resistant (CR) Klebsiella pneumoniae isolates. Molecular analysis was carried out...