A5059076002- HIV Research and Treatment
- HIV, TB, and STIs Epidemiology
- HIV, Drug Use, Sexual Risk
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Yersinia bacterium, plague, ectoparasites research
- Rabies epidemiology and control
- Diagnosis and treatment of tuberculosis
- Genital Health and Disease
- Biochemical and Molecular Research
- Bacteriophages and microbial interactions
- Cervical Cancer and HPV Research
- Viral Infections and Vectors
- Hepatitis C virus research
- Viral gastroenteritis research and epidemiology
- Bacillus and Francisella bacterial research
- Animal Virus Infections Studies
- HIV/AIDS Impact and Responses
- Animal health and immunology
Moscow State Academy of Veterinary Medicine and Biotechnology named after Skryabin
2022
Ministry of Health of the Russian Federation
2012-2020
Institute of Virology of the Slovak Academy of Sciences
2016-2017
D.I. Ivanovsky Institute of Virology Russian Academy of Medical Sciences
2012-2017
Gamalei Institute of Epidemiology and Microbiology
2016
A molecular analysis of HIV-1 subtypes and recombinants circulating in cities the Russian Far East was performed. The study included samples from 201 outpatients Vladivostok, Khabarovsk, Blagoveshchensk. In most parts Russia, patients are infected with subtype A, known as IDU-A variant. Subtype B, including IDU-B variant, is rare Russia but widespread Ukraine, CRF02_AG prevalent Central Asian countries Siberia, Russia. One challenges this to determine whether landscape HIV infection region...
To analyze HIV-1 genetic variants in Kazakhstan, sequences were obtained from 205 antiretroviral-treated (ART) and naive patients 2009-2013. Samples collected the most populous cities provinces of Kazakhstan. On basis phylogenetic analyses partial pol sequences, subtype A variant intravenous drug user (IDU)-A (which is dominant former Soviet Union) was found 60.0% individuals, followed by CRF02_AG (34.6%); rest samples B, CRF03_AB, CRF63_02A1, CRF07_BC. The proportion has increased...
The men who have sex with (MSM) population infected HIV is poorly studied in Russia because of stigma and discrimination. In the first years epidemic, only genetic variant that circulated among MSM was subtype B, usually acquired abroad. Meanwhile, massive epidemic caused by a highly homogenic A variant, AFSU (A6), spread mainly drug users. this study, 155 pol sequences from collected during 2006-2016 period were analyzed. Phylogenetic analysis found 19.4% viral clustered variants A6 BFSU,...
Natural variability of integrase (IN) across HIV-1 variants may influence the emergence resistant viruses. The most apparent explanation this fact is IN polymorphism and associated differences in codon usage, which turn, probability terms DRMs acquisition. Possible mechanisms by polymorphisms affect remain disputed should still be clarified because these substitutions with a reduced activity some INSTIs impact on ART regimen choice depending subtype.The aim work was to assess prevalence...
There is scarce information about the molecular epidemiology of HIV-infection in Armenia (former USSR). The objective this work was to estimate distribution HIV-1 subtypes country and get any HIV drug resistance naÏve patients.A joint study involving 78 patients carried out Yerevan, Moscow, Russia 2009-2013. cohort studies included mostly IDUs (28.2%) heterosexuals (69.2%).The phylogenetic analyses based on population sequencing partial pol gene found subtype A1 being most prevalent (92.3%),...
The results of the molecular-epidemiological analysis HIV-1 variants circulating in Arkhangelsk and Murmansk - northern seaports Russia were presented. In these belonging to subtype A1 predominant (93% Murmansk, 83% Arkhangelsk). addition variants, viruses other subtypes such as B, C, D recombinant forms CRF02_AG CRF03_AB identified. heterogeneity was higher than Murmansk. According phylogenetic analysis, sequences formed common branch with nucleotide IDU-A strains found regions Russia. B...
Women living with HIV-1 are at high risk of infection human papillomavirus carcinogenic (HR HPVs). M. tuberculosis (TB) promotes HPV and increases the to develop HPV-associated cancer. Our knowledge persisting HR HPVs genotypes, factors promoting in people clinical TB manifestations is sparse. Here, we analyzed 58 women (WLWH TB) followed up specialized centers Russia, a middle income country endemic for TB, presence cervical smears DNA twelve genotypes. encoding HPV16 E5, E6/E7 was...
The pol and env genome regions of the HIV-1 genetic variants circulating in irkutsk region russia 1999 2012 were compared. results this work showed dominance subtype a IDU-A variant (100%) region. No primary resistance mutations gene treatment-naive patients found. heterogeneity viral population was found to be significantly increased based on analysis among HIV-variants isolated (12.88% 2.16%) from intravenous drug users as compared that caused outbreak HIV infection (1.64% 0.47%). In...
Objectives During the last two decades, HIV‐1 has been spreading rapidly in former Soviet Union republics including Kyrgyzstan. The current molecular monitoring of HIV‐infection epidemic is carried out Russia only with no or limited data from other FSU countries. aim this work was to investigate prevalence genetic variants circulating Methods Blood collection HIV‐infected patients by local specialists informed consent and questionnaire answered each patients. total number samples 100. washed...
In the present work, a total of 132 HIV-1 env gene C2-V3-C3 sequences belonging to IDU-A genetic variant were analyzed. The variants obtained from viruses circulating among IDUs and heterosexuals in Perm region at different periods. It was shown that rate divergence common ancestor increased 4.3 times (p < 0.001) 2011 as compared with onset epidemics. evolution two risk groups infection. mean distance 1.3 longer = 0.008) than IDUs. accumulation nucleotide (including nonsynonymous)...
Introduction : the analysis of genetic variants in Republic Crimea has so far been limited to 2006 study. The prevalence HIV infection on peninsula is 20% higher than national average, with 80% infections associated sexual transmission. In addition, interruptions supply drugs since 2014 create conditions for active emergence drug-resistant strains HIV. Objective study molecular circulating 2017–2018. Materials and methods: work analyzes genotype sequences HIV-1 pol gene fragment obtained...
Purpose of the study Monitoring primary resistance in HIV‐1 variants circulating Russia and FSU countries is important task HIV infection molecular epidemiology. The data epidemiology are absent or limited many countries. IDU‐A variant subtype A has been dominating (>90%) other since 1996. Additionally, Central Asian region (e.g. Kazakhstan Uzbekistan) characterized by relatively wide spread CRF02_AG recombinant. aim our was analysis drug from Kazakhstan. Methods Blood collection...
Abstract Currently, there is a number of sources that are available and can be used for review research in molecular biology other related disciplines. Every one them has its own data storage format, different level redundancy, interconnections with or comparable databases. At the same time, each database means access to information such as various search programs, software media updates new data. The most extensive collections primary DNA structures amino acid sequences supplemented...
Anna A. Oleshkevich, Specific features of change in enzymate activity