A5008109254- RNA regulation and disease
- RNA Research and Splicing
- interferon and immune responses
- Viral Infections and Immunology Research
- Mosquito-borne diseases and control
- Invertebrate Immune Response Mechanisms
- Inflammasome and immune disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Malaria Research and Control
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Leiden University Medical Center
2020-2024
Utrecht University
2021
University Medical Center Utrecht
2019-2021
Oncode Institute
2021
Leiden University
2021
Abstract Vault RNAs (vtRNAs) are a family of four small non-coding (ncRNAs) that ubiquitously expressed in many eukaryotes and regulate multiple cellular pathways. Their expression is increased upon infection with various DNA RNA viruses. This suggests they either co-opted by the virus to aid replication or function as an antiviral restriction factor. However, their precise molecular remains unclear. Here, we show picornaviruses, alphaviruses, beta-coronaviruses broadly enhances vtRNA...
Abstract Inhibitory and activating immune receptors play a key role in modulating the amplitude duration of responses during infection maintaining balance homeostatic conditions. The CD200 Receptor (CD200R) gene family humans encodes one inhibitory receptor, CD200R1, putative member, CD200R1 Like (CD200R1L). It is demonstrated that CD200R1L endogenously expressed by human neutrophils activates cellular functions such as reactive oxygen species (ROS) production via Syk, PI3Kβ, PI3Kδ, Rac...
Abstract RNA editing by the enzyme Adenosine Deaminase Acting on 1 (ADAR1) is an important mechanism which cells avoid innate immune responses to some endogenous RNAs. In ADAR1-deficient cells, unedited self RNAs can form base-paired structures that resemble viral and inadvertently activate antiviral pathways lead induction of type I interferon (IFN). Rare mutations in ADAR1 cause Aicardi-Goutières Syndrome (AGS), a severe childhood autoinflammatory syndrome characterized chronic excessive...