A5059555729- RNA Research and Splicing
- CAR-T cell therapy research
- RNA and protein synthesis mechanisms
- Neurobiology and Insect Physiology Research
- Ubiquitin and proteasome pathways
- Immune Cell Function and Interaction
- Cellular transport and secretion
- T-cell and B-cell Immunology
- Advanced Fluorescence Microscopy Techniques
University of Oxford
2022-2023
University of Warwick
2023
While post-transcriptional control is thought to be required at the periphery of neurons and glia, its extent unclear. Here, we investigate systematically spatial distribution expression mRNA single molecule sensitivity their corresponding proteins 200 YFP trap lines across intact Drosophila nervous system. 97.5% genes studied showed discordance between they encode in least one region These data suggest that regulation very common, helping explain complexity We also discovered 68.5% these...
Summary While post-transcriptional control is thought to be required at the periphery of neurons and glia, its extent unclear. Here, we investigate systematically spatial distribution expression mRNA single molecule sensitivity their corresponding proteins 200 YFP trap protein lines across intact Drosophila nervous system. 98% genes studied showed discordance between they encode in least one region These data suggest that regulation very common, helping explain complexity We also discovered...
Expression of the pre-T cell receptor (preTCR) is an important checkpoint during development T cells, essential type our adaptive immune system. The preTCR complex only transiently expressed and rapidly internalized in developing cells thought to signal a ligand-independent manner. However, identifying mechanistic basis for these unique features compared with final TCR has been confounded by concomitant signaling that normally present. Thus, we have reconstituted expression non-immune...