A5085934112- Immune Cell Function and Interaction
- Immune cells in cancer
- Pancreatic function and diabetes
- Immune responses and vaccinations
- Reproductive Biology and Fertility
- Diabetes and associated disorders
- Reproductive Physiology in Livestock
- Cancer Research and Treatments
- Chemokine receptors and signaling
- Cancer, Stress, Anesthesia, and Immune Response
- Diabetes Management and Research
- Immunotherapy and Immune Responses
- Reproductive System and Pregnancy
- Cancer Immunotherapy and Biomarkers
University of Missouri
2023-2025
Center of Molecular Immunology (Cuba)
2023
Institute of Child Health
2023
More than 60% of pregnancy losses occur during the first trimester, highlighting need to understand role oviduct in early pregnancy. In this study, we conditionally ablated classical progesterone receptor ( Pgr ) oviductal epithelial cells, called d/d mouse model. We found that 40% embryos collected from females were nonviable or developmentally delayed, indicating PGR expression is crucial for embryonic development. Single-cell RNA sequencing revealed up-regulation proinflammatory genes,...
Abstract Introduction: A novel CD137 agonist, SA-4-1BBL, as a single agent is effective in training the immune system to prevent cancer development preclinical models. The immunoprevention efficacy of SA-4-1BBL tumor-type independent, long-lasting (>14 weeks), and requires cells expressing CD4 or NK1.1 molecules but not CD8+ T cells, implicating innate surveillance. Since NKT express both NK1.1, we herein investigated role these phagocytes, neutrophils SA-4-1BBL. Study Design:...
The instant blood-mediated inflammatory reaction (IBMIR) is initiated by innate immune responses that cause substantial islet loss after intraportal transplantation. Thrombomodulin (TM) a multifaceted modulator. In this study, we report the generation of chimeric form thrombomodulin with streptavidin (SA-TM) for transient display on surface islets modified biotin to mitigate IBMIR. SA-TM protein expressed in insect cells showed expected structural and functional features. converted C into...
Abstract Introduction: We recently demonstrated that pretreatment of mice with SA-4-1BBL, a novel oligomeric form CD137 agonist, as single agent prevents the development various tumor types in mice. The immunoprevention efficacy is long-lasting (>14 weeks) and contingent upon CD4+ immune cells, NK IFN-γ, but not CD8+ T B cells. Trained immunity mediated by previously activated myeloid cells has been shown to have against cancer. objective this study was twofold: i) assess role trained...
Abstract The use of immune checkpoint stimulators is an increasingly attractive therapeutic approach against cancer, and costimulatory pathway agonists are being developed for clinical use. Our laboratory has focused on the 4-1BB (CD137) because its critical role in CD8+ T cell expansion, survival, acquisition effector function, establishment long-term memory. We previously reported generation a recombinant oligomeric form mouse ligand, muSA-4-1BBL, which, unlike natural demonstrated robust...