A5036959213- Genetics, Aging, and Longevity in Model Organisms
- Plant Molecular Biology Research
- Plant Reproductive Biology
- Plant Gene Expression Analysis
- Glycosylation and Glycoproteins Research
- Carbohydrate Chemistry and Synthesis
- Bryophyte Studies and Records
- Wnt/β-catenin signaling in development and cancer
- Renal and related cancers
- Circadian rhythm and melatonin
- Plant and animal studies
- Genetic Mapping and Diversity in Plants and Animals
- Protist diversity and phylogeny
- Cell Adhesion Molecules Research
- Bioinformatics and Genomic Networks
- Muscle Physiology and Disorders
- Plant Stress Responses and Tolerance
- Genetic and rare skin diseases.
- Gene Regulatory Network Analysis
- Pancreatic function and diabetes
- Genetic and Kidney Cyst Diseases
- Axon Guidance and Neuronal Signaling
- Hippo pathway signaling and YAP/TAZ
- Developmental Biology and Gene Regulation
- Cancer and Skin Lesions
Max Planck Institute for Plant Breeding Research
2015-2020
Bejo Zaden (Netherlands)
2019-2020
Royal Netherlands Academy of Arts and Sciences
2013-2018
University Medical Center Utrecht
2013-2018
Wageningen University & Research
2011
Cancer Research UK Cambridge Center
2011
A key challenge in biology is to understand how the regional control of cell growth gives rise final organ forms. Plant leaves must coordinate along both proximodistal and mediolateral axes produce their shape. However, cell-level mechanisms controlling this coordination remain largely unclear. Here, we show that, A. thaliana, WOX5, one WUSCHEL-RELATED HOMEOBOX (WOX) family homeobox genes, acts redundantly with WOX1 WOX3 (PRESSED FLOWER [PRS]) leaf Through genetics hormone measurements, find...
Here we investigate mechanisms underlying the diversification of biological forms using crucifer leaf shape as an example. We show that evolution enhancer element in homeobox gene REDUCED COMPLEXITY ( RCO ) altered by changing expression from distal blade to its base. A single amino acid substitution evolved together with this regulatory change, which reduced protein stability, preventing pleiotropic effects caused expression. detected hallmarks positive selection these and coding sequence...
Mechanisms through which the evolution of gene regulation causes morphological diversity are largely unclear. The tremendous shape variation among plant leaves offers attractive opportunities to address this question. In cruciferous plants, REDUCED COMPLEXITY (RCO) homeodomain protein evolved via duplication and acquired a novel expression domain that contributed leaf diversity. However, molecular pathways RCO regulates growth unknown. A key question is identify genome-wide transcriptional...
Regulation of gene expression by signaling pathways often occurs through a transcriptional switch, where the transcription factor responsible for signal-dependent activation represses same targets in absence signaling. T-cell factors (TCFs) are Wnt/ß-catenin pathway, which control numerous cell fate specification events metazoans. The TCF switch is mediated many co-regulators that contribute to repression or Wnt target genes. It typically assumed DNA recognition TCFs important location, but...
Van Gogh-like (Vangl) and Prickle (Pk) are core components of the non-canonical Wnt planar cell polarity pathway that controls epithelial migration. Studies in vertebrate model systems have suggested Vangl Pk may also inhibit signaling through canonical Wnt/β-catenin pathway, but functional significance this potential cross-talk is unclear. In nematode C. elegans, Q neuroblasts their descendants migrate opposite directions along anteroposterior body axis. The direction these migrations...
How the interplay between cell- and tissue-level processes produces correctly proportioned organs is a key problem in biology. In plants, relative size of leaves compared with their lateral appendages, called stipules, varies tremendously throughout development evolution, yet relevant mechanisms remain unknown. Here we use genetics, live imaging, modeling to show that Arabidopsis , LATE MERISTEM IDENTITY1 (LMI1) homeodomain protein regulates stipule proportions via an...
Mutations in Lef1 occur human and mouse sebaceous gland (SG) tumors, but their contribution to carcinogenesis remains unclear. Since Gata6 controls lineage identity SG, we investigated the link between these two transcription factors. Here, show that is a β-catenin-independent transcriptional target of mutant Lef1. During epidermal development, expressed subset Sox9-positive Lef1-negative hair follicle progenitors give rise upper SG Overexpression by utero lentiviral injection sufficient...
Establishment of cell polarity is crucial for many biological processes including migration and asymmetric division. The establishment consists two sequential processes: an external gradient first sensed then the resulting signal amplified maintained by intracellular signaling networks usually using positive feedback regulation. Generally, these are intertwined it challenging to determine which proteins contribute sensing or amplification process, particularly in multicellular organisms....
SUMMARY The origin of a terrestrial flora in the Ordovician required adaptation to novel biotic and abiotic stressors. Oil bodies, synapomorphy liverworts, accumulate secondary metabolites, but their function development are poorly understood. bodies Marchantia polymorpha develop within specialized cells as one single large organelle. Here, we show that CLASS I HOMEODOMAIN LEUCINE-ZIPPER (C1HDZ) transcription factor controls differentiation oil body two different ecotypes liverwort M. ,...