A5074592003- Biomedical and Chemical Research
- Pharmacovigilance and Adverse Drug Reactions
- Thermal Regulation in Medicine
- Computational Drug Discovery Methods
- Airway Management and Intubation Techniques
- Pharmacogenetics and Drug Metabolism
- Thermoregulation and physiological responses
- Drug-Induced Adverse Reactions
- Alcoholism and Thiamine Deficiency
- Advanced MRI Techniques and Applications
- Anesthesia and Sedative Agents
- Cardiac Health and Mental Health
- Heart Failure Treatment and Management
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Drug Transport and Resistance Mechanisms
- Metabolism and Genetic Disorders
- Health and Medical Studies
- Neuroscience and Neuropharmacology Research
- Biomedical Text Mining and Ontologies
- Muscle and Compartmental Disorders
- Pharmacology and Obesity Treatment
- Intensive Care Unit Cognitive Disorders
- Respiratory and Cough-Related Research
- Acute Ischemic Stroke Management
Kiel University
2013-2024
University Hospital Schleswig-Holstein
2011-2024
University of Lübeck
2011-2024
Clinical Research Center Kiel
2018-2021
University Medical Center
2018
Regio Kliniken
2011-2015
Energetický a Průmyslový Holding (Czechia)
2015
Asklepios Klinik St. Georg
2015
Evangelisches Krankenhaus Bielefeld
2015
Pharmacovigilance contributes to health care. However, direct access the underlying data for academic institutions and individual physicians or pharmacists is intricate, easily employable analysis modes everyday clinical situations are missing. This underlines need a tool bring pharmacovigilance clinics. To address these issues, we have developed OpenVigil FDA, novel web-based which uses openFDA online interface of Food Drug Administration (FDA) U.S. American international from Adverse Event...
The aim of our study was to evaluate the performance different durations active pre-operative skin-surface warming (pre-warming) prevent peri-operative hypothermia and postoperative shivering. We randomly assigned 200 patients, scheduled for surgery 30-90 min under general anaesthesia, receive passive insulation or forced-air skin surface 10, 20 30 min. Body temperature measured at tympanic membrane. Shivering graded by visual inspection. There were significant differences in changes core...
Pharmacogenomics aims to correlate inter-individual differences of drug efficacy and/or toxicity with the underlying genetic composition, particularly in genes encoding for protein factors and enzymes involved metabolism transport. In several European populations, countries lower income, information related prevalence pharmacogenomic biomarkers is incomplete or lacking. Here, we have implemented microattribution approach assess allelic spectrum 18 mostly from developing countries, by...
Pharmacovigilance data are primarily used to identify adverse drug reactions by screening for disproportionate reporting, i.e. more reports of certain combinations events and drugs than expected. However, scanning associations that occur less frequently expected provides hypotheses repurposing, a known could be therapeutically beneficial new indication such as the coronavirus disease (COVID-19). As coronavirus-related scarce in pharmacovigilance prior 2020, we searched suitable against...
BACKGROUND Epidural analgesia (EDA) is known to be an independent risk factor for perioperative hypothermia and its many adverse effects. Combined general epidural anaesthesia decreases intraoperative core temperature more rapidly than alone. Hence, adequate warming procedures are needed these patients. OBJECTIVE We evaluated the effects of active skin-surface before and/or after initiation EDA during as a procedure prevent hypothermia. DESIGN A randomised controlled trial. SETTING...
vessel sign was 54% (range 32%-100%) for T2* (668 patients) and 81% 34%-100%) SWI (334 patients).There rare mentioning of interrater agreement (6 publications, 210 reliability (1 publication, 20 but the numbers reported ranged from good to excellent.In most publications (n = 22) perfusion MRI used as a validation method (617 patients).More patients were scanned in subacute than acute phase (596 vs 320 patients).Clinical outcome 13 (521 not consistent. CONCLUSION:The low presence vessels...
The prevention of inadvertent perioperative hypothermia requires precise, reliable and practical methods temperature measurement in both awake anaesthetised patients. Different sites monitoring have been evaluated, but many are imprecise, unusable patients, difficult to apply or too invasive, especially for minor surgery. aim this study was evaluate the performance sublingual tympanic patients.We enrolled 171 aged 18-75 years, scheduled surgery with duration less than 1 h under general...
ATP-binding cassette (ABC) transporters represent a large group of efflux pumps that are strongly involved in the pharmacokinetics various drugs and nutrient distribution. It was recently shown micro-RNAs (miRNAs) may significantly alter their expression as proven, e.g., for miR-379 <i>ABCC2</i>. However, alternative mRNA polyadenylation result 3′-untranslated regions (3′-UTRs) with varying lengths. Thus, length variants presence or absence miRNA binding sites regulatory miRNAs consequences...
Senior individuals can suffer from immunosenescence and novel strategies to bolster the immune response could contribute healthy ageing. In this double-blind, randomised, controlled pilot trial, we investigated ability of non-digestible polysaccharide (NPS) preparations enhance in a human vaccination model. total, 239 subjects (aged 50–79 years) were randomised consume one five different NPS (yeast β-glucan (YBG), shiitake (SBG), oat (OBG), arabinoxylan (AX), bacterial exopolysaccharide...
Although chronic myeloid leukemia (CML) can be effectively treated using BCR‑ABL1 kinase inhibitors, resistance due to alterations or independent mechanisms remain a therapeutic challenge. For the latter, underlying are widely discussed; for instance, gene expression changes, epigenetic factors and alternative signaling pathway activation. In present study, <em>in vitro</em>‑CML cell models of against tyrosine inhibitors (TKIs) imatinib (0.5 2 µM) nilotinib (0.1 with biological replicates...
alpha(2)-Adrenergic and mu-opioid receptors belong to the rhodopsin family of G-protein coupled mediate antinociceptive effects via similar signal transduction pathways. Previous studies have revealed direct functional interactions between both receptor systems including synergistic additive effects. To evaluate underlying mechanisms, we studied whether morphine fentanyl interacted with alpha(2)-adrenoceptor-subtypes in mice lacking one individual alpha(2)-adrenoceptor-subtype...
Electrical Properties Tomography (EPT) is a new sequence which delivers information on tissue electrical conductivity. It has been mostly used for tumor imaging. Ischemic stroke another promising application. The aim of this study was to demonstrate the feasibility EPT in rodent model stroke. Wistar rats with and without temporary middle cerebral occlusion (MCAo) were examined 3T scanner. performed using Steady-State Free-Precession (SSFP) sequence. From transceive phase ɸ these SSFP scans,...
The significance of human biorepositories for modern medical research, particularly comprehensive population-based genetic analyses, is constantly growing. While large and centralized institutions are usually considered best suited to meet the increasing demand high-quality "biobanks," most research still host rather heterogeneous fragmented biobanking activities, undertaken by clinical departments with oftentimes different scientific scope. Undoubtedly, clinicians researchers would...
Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Gliflozins are effective drugs for the treatment of type 2 diabetes. They inhibit sodium glucose cotransporter in proximal renal tubule, leading to increased excretion. On basis findings from relevant studies, gliflozins also increasingly used clinical practice treat congestive heart failure and failure.
Abstract Background Spironolactone (SPL) is a reversible mineralocorticoid receptor (MR) and androgen (AR) antagonist which attracts pharmacotherapeutic interest not only because of its beneficial effects in heart failure but also the pathogenetic roles MR AR activities neuropsychiatric diseases. Recently, rapid‐onset SPL have been documented case series women with fibromyalgia syndrome (FMS). To reaffirm this observation, we performed double‐blind placebo‐controlled randomized clinical...
Background . Xenon seems to be an ideal anesthetic drug. To explore if next the antagonism at NMDA-receptor other molecular targets are involved, we tested xenon requirement in short sleeping Drosophila shaker mutants and Methods The melanogaster strains wildtype Canton-S, , were raised sleep was measured. Based on response of flies different concentrations, logEC50 values calculated. Results logEC50-values for WT Canton-S 1.671 (1.601–1.742 95%-confidence intervall; ; P versus > 0,05),...