A5018391981- melanin and skin pigmentation
- Skin Protection and Aging
- Biochemical Analysis and Sensing Techniques
- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- Cancer-related Molecular Pathways
- Olfactory and Sensory Function Studies
- Melanoma and MAPK Pathways
- Economic and Financial Impacts of Cancer
- Neuroblastoma Research and Treatments
- Immune Cell Function and Interaction
- Sarcoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Acute Lymphoblastic Leukemia research
- Renal and related cancers
- Childhood Cancer Survivors' Quality of Life
- Hematological disorders and diagnostics
- Computational Drug Discovery Methods
- Cardiac tumors and thrombi
- Antimicrobial Peptides and Activities
- Dye analysis and toxicity
- Extracellular vesicles in disease
- Sirtuins and Resveratrol in Medicine
- Plant Gene Expression Analysis
University of Kentucky
2016-2025
Markey Cancer Center
2015-2025
University of Kentucky HealthCare
2024
Mary Kay (United States)
2024
University of California, Merced
2018
The Graduate Center, CUNY
2009-2015
Molecular Oncology (United States)
2013
University of Cape Town
2013
Charles University
2013
Dana-Farber Cancer Institute
2007
We tested whether novel CYP11A1-derived vitamin D3- and lumisterol-hydroxyderivatives, including 1,25(OH)2D3, 20(OH)D3, 1,20(OH)2D3, 20,23(OH)2D3, 1,20,23(OH)3D3, lumisterol, 20(OH)L3, 22(OH)L3, 20,22(OH)2L3, 24(OH)L3, can protect against UVB-induced damage in human epidermal keratinocytes. Cells were treated with above compounds for 24 h, then subjected to UVB irradiation at doses of 25, 50, 75, or 200 mJ/cm2, examined oxidant formation, proliferation, DNA damage, the expression genes mRNA...
Abstract Background Pediatric, adolescent, and young adult patients with cancer their caregivers are at high risk of financial toxicity, few evidence-based oncology legal navigation programs exist to address it. We tested the feasibility, acceptability, preliminary effectiveness Financial Insurance Navigation Assistance, a novel interdisciplinary intervention for pediatric, adolescent caregivers. Methods used single-arm feasibility acceptability trial design in pediatric hematology clinic...
Abstract The epidermis increases pigmentation and epidermal thickness in response to ultraviolet exposure protect against UV ‐associated carcinogenesis; however, the contribution of has been debated. In a humanized skin mouse model that maintains interfollicular melanocytes, we found forskolin, small molecule directly activates adenylyl cyclase promotes cAMP generation, up‐regulated eumelanin accumulation fair‐skinned melanocortin‐1‐receptor ( M c1r)‐defective animals. Forskolin‐induced was...
Hull blackberries were purified using solid phase extraction to obtain anthocyanin-rich methanol fractions. This method concentrated phenolics and anthocyanins, recovering 97% 76% of the total yield in puree or powder extracts, respectively, which represented a 24-63 fold increase antioxidant capacity when compared with either water fraction original extract. The ability these fractions protect primary keratinocytes against UV-induced oxidative damage was assessed. Anthocyanin-rich derived...
Few evidence-based trainings exist on how to equip healthcare providers, particularly nurses, with the skills engage in cost of care conversations patients/caregivers mitigate impact cancer-related financial toxicity. This study evaluated a pilot training developed collaboration Triage Cancer® prepare oncology nurses identify and assist facing and/or legal barriers care. Ten pediatric completed pre/post-surveys behaviors related need screening, frequency comfort level answering questions,...
We identified a germline TP53 c.758C>T (p.T253I) mutation in the tumor suppressor gene pediatric adrenocortical carcinoma (ACC) patient. Characteristic to pathogenic p53 mutations, we observed upregulation of total protein levels patient’s ACC and concurrent suppression wild-type (WT) allele. As can be associated with Li-Fraumeni Syndrome (LFS) has not yet been linked LFS, sought characterize functionality T253I mutation. acquired p53-/- HEK293 cells stably transduced them GFP-tagged wild...
Background: Malignant Ectomesenchymoma (MEM) is a rare, aggressive soft tissue neoplasm with both neuroectodermal and mesenchymal differentiation. Congenital cases are extremely uncommon, posing significant diagnostic therapeutic challenges. Case Presentation: We report case of full-term male neonate presenting large congenital neck mass respiratory distress at birth. Imaging revealed lobulated, heterogeneously enhancing in the left submandibular region effect on airway. Open biopsy gross...
Introduction: Adolescent and young adult cancer survivors, especially racial/ethnic minorities rural residents are particularly vulnerable to financial toxicity due limited healthcare access, socioeconomic disparities, cultural/language barriers. These social determinants of health compound hardship contribute poor transitions from pediatric care, leading worse outcomes higher mortality rates.Methods: Our cross-sectional survey study examined racial (Black vs White) geographic (rural urban)...
Blunted melanocortin 1 receptor (MC1R) signaling promotes melanocyte genomic instability in part by attenuating cAMP-mediated DNA repair responses, particularly nucleotide excision (NER), which recognizes and clears mutagenic photodamage. cAMP-enhanced NER is mediated interactions between the ataxia telangiectasia-mutated Rad3-related (ATR) xeroderma pigmentosum complementation group A (XPA) proteins. We now report a critical role for sirtuin (SIRT1) regulating ATR-mediated phosphorylation...
We previously reported that topical application of forskolin to the skin fair-skinned MC1R-defective mice with epidermal melanocytes resulted in accumulation eumelanin epidermis and was highly protective against UV-mediated cutaneous injury. In this report, we describe long-term effects chronic treatment animal model. Forskolin-induced production persisted through 3 months daily applications, forskolin-induced remained UV damage as assessed by minimal erythematous dose (MED). No obvious...
Staphylococcal enterotoxin B (SEB) is known for its effects on T lymphocytes; the mechanism of this activation well studied. Although it anticipated that there would be other cells in milieu, mechanisms non-T immune are not understood. This report examines SEB human NK cells. Incubation PBMC with augmented cytotoxicity against NK-sensitive targets K562 and Molt-4 induced activity NK-resistant targets, Mel-30 Raji. The degree superantigen-augmented killer (SAK) by treatment correlated...