A5100419602- Glycosylation and Glycoproteins Research
- Liver Disease Diagnosis and Treatment
- Zeolite Catalysis and Synthesis
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Advanced biosensing and bioanalysis techniques
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Hepatitis C virus research
- Phytochemistry and Biological Activities
- Catalysis and Oxidation Reactions
- Polymer Surface Interaction Studies
- Proteoglycans and glycosaminoglycans research
- Hepatocellular Carcinoma Treatment and Prognosis
- Chalcogenide Semiconductor Thin Films
- Drug Transport and Resistance Mechanisms
- Catalysts for Methane Reforming
- Hydrogen embrittlement and corrosion behaviors in metals
- RNA modifications and cancer
- Influenza Virus Research Studies
- Ginseng Biological Effects and Applications
- Enzyme Structure and Function
- COVID-19 Clinical Research Studies
- Traditional Chinese Medicine Analysis
- Corrosion Behavior and Inhibition
Sichuan University
2022-2025
Bozhou People's Hospital
2024
Institute of Hematology & Blood Diseases Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Anhui University of Technology
2023
Southern University of Science and Technology
2023
Ministry of Education of the People's Republic of China
2023
Duke University
2021-2022
Yuntianhua Group (China)
2021
Hong Kong Baptist University
2019-2021
Despite the emergence of new direct-acting antivirals, hepatitis C virus (HCV) chronic infection and its consequent fibrosis hepatocarcinoma remain a significant burden for public health, thus requiring an effective preventive vaccine. Our group previously showed that subunit vaccine based on recombinant soluble E2 (sE2) can induce broadly neutralizing antibodies. To improve immunogenicity sE2, we designed produced fusion protein (sE2-ferritin) comprising sE2 ferritin unit in Drosophila S2...
YiQiFuMai Powder Injection (YQFM) is a re-developed preparation based on the well-known traditional Chinese medicine formula Sheng-mai-san. It has been widely used for treatment of cardiovascular disease with definite clinical efficacy in China, but its bioactive molecules remain obscure. In this study, an effective method employed as tool screening active components YQFM, using human umbilical vein endothelial cells (HUVECs) extraction and liquid chromatography coupled electrospray...
Abstract Background Microwave ablation (MWA) is widely used to treat unresectable primary and secondary malignancies of the liver, a limited number studies indicate that can cause not only necrosis at in situ site but also an immunoreaction whole body. This study aimed investigate effects MWA on cytokines patients who underwent for hepatic malignancy. Methods Patients admitted Oncology Department First Affiliated Hospital Soochow University between June 2015 February 2019 were selected....
Polydopamine (PDA), inspired by the adhesive mussel foot proteins, is widely applied in chemical, biological, medical, and material science due to its unique surface coating capability abundant active sites. Energetic materials (EMs) play an essential role both military civilian fields as a chemical energy source. Recently, PDA was introduced into EMs for modification of crystal phase stability interfacial bonding effect, and, result, enhance mechanical, thermal, safety performances. This...
Chemical laboratories, as the cornerstone of scientific innovation, face inherent risks due to nature their operations. Hazards such flammable, explosive, and corrosive chemicals, combined with high-pressure high-temperature conditions, present significant safety challenges. Accidents not only jeopardize health personnel but also risk equipment damage, environmental pollution, broader societal impacts. Ensuring a safe laboratory environment demands multifaceted approach involving all...
Mesopore size can be readily tuned by synergistic effects of the surfactant concentration and amphiphilic agents for various sizes guest loading.
The global control of hepatitis C virus (HCV) infection remains a great burden, owing to the high prices and potential drug resistance new direct-acting antivirals (DAAs), as well risk reinfection in DAA-cured patients. Thus, prophylactic vaccine for HCV is importance. We previously reported that single recombinant soluble E2 (sE2) produced insect cells was able induce broadly neutralizing antibodies (NAbs) prevent mice. Here sE2 evaluated non-human primates. Rhesus macaques were immunized...
A rational strategy was introduced for the synthesis of a novel dual functionalized metal–organic framework nanocomposite (AuGC/ZIF-8) with ultra-hydrophilicity to enhance glycopeptide enrichment.
In this study, high‐performance liquid chromatography coupled with tandem mass spectrometry was used to assess the results of bioactive compound screening from natural products using immobilized enzyme magnetic beads. We compared three commercial beads modified amino, carboxy, and N ‐hydroxysuccinimide groups, respectively. Amino performed best for immobilization were selected further experiments. Xanthine oxidase on amino applied screen potential inhibitors in fresh Zingiber officinale...
Protein glycosylation is ubiquitous and crucial for regulating biological processes in organisms. Given the heterogeneity low abundance of glycoproteins, efficient specific enrichment procedures are required mass spectrometry analysis glycopeptides. Hydrophilic interaction liquid chromatography (HILIC) has emerged as an effective strategy glycopeptide enrichment. However, relatively weak hydrophilic affinity restricts achievement a satisfactory performance. Here, we presented rational design...
Abstract Multidrug resistance is recognized as one of the main reasons leading to failure chemotherapy. Studies have shown that glutathione S‐transferase inhibitors could be regarded multidrug reversal agents. Herein, a method applying enzyme immobilization, molecular docking, and high‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry was employed screen from natural products. Magnetic mesoporous silica microspheres were synthesized modified...
Background: Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous cancer characterized by difficulties in early diagnosis outcome prediction. Aberrant glycosylated structures produced the aberrant expression of glycosyltransferases are prevalent HNSCC. In this study, we aim to construct glycosyltransferase-related gene signatures with diagnostic prognostic value better stratify patients HNSCC improve their prognosis. Methods: Bioinformatic tools were used process data from...