A5019781953- SARS-CoV-2 and COVID-19 Research
- MicroRNA in disease regulation
- Bone Metabolism and Diseases
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- COVID-19 Impact on Reproduction
- Immune cells in cancer
- COVID-19 Clinical Research Studies
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Genital Health and Disease
- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- Dupuytren's Contracture and Treatments
- T-cell and B-cell Immunology
- Circular RNAs in diseases
- Cancer-related gene regulation
- Diabetes and associated disorders
- Mesenchymal stem cell research
- Venomous Animal Envenomation and Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Bone and Joint Diseases
- Infant Nutrition and Health
- Biomedical and Engineering Education
University of Nicosia
2015-2025
Center for the Study of Childhood and Adolescence
2013-2015
University of Oxford
2012-2013
Nuffield Orthopaedic Centre
2013
British Society for Rheumatology
2009
Imperial College London
2009
A major therapeutic challenge is how to replace bone once it lost. Bone loss a characteristic of chronic inflammatory and degenerative diseases such as rheumatoid arthritis osteoporosis. Cells cytokines the immune system are known regulate turnover by controlling differentiation activity osteoclasts, resorbing cells. However, less about regulation osteoblasts (OB), forming This study aimed investigate whether cells also OB differentiation. Using in vitro cell cultures human marrow-derived...
Dupuytren's disease is a very common progressive fibrosis of the palm leading to flexion deformities digits that impair hand function. The cell responsible for development myofibroblast. There currently no treatment early or preventing recurrence following surgical excision affected tissue in advanced disease. Therefore, we sought unravel signaling pathways myofibroblasts We characterized cells present and found significant numbers immune cells, including classically activated macrophages....
The aim of this study was to examine whether circulating levels the pro-inflammatory glycoprotein tenascin-C (TNC) are elevated in musculoskeletal disorders including rheumatoid arthritis (RA) and assess RA related clinical disease status and/or patient response treatment. TNC serum or plasma quantified by ELISA. Samples from 4 cohorts patients were examined compared normal human subjects with other inflammatory diseases. Circulating significantly raised RA, as well systemic lupus...
Design of dual antagonists for the chemokine receptors CCR2 and CCR5 will be greatly facilitated by knowledge structural differences their binding sites. Thus, we computationally predicted site CCR2/CCR5 antagonist <i>N</i>-dimethyl-<i>N</i>-[4-[[[2-(4-methylphenyl)-6,7-dihydro-5<i>H</i>-benzohepten-8-yl] carbonyl]amino]benzyl]tetrahydro-2<i>H</i>-pyran-4-aminium (TAK-779), a CCR2-specific <i>N</i>-(carbamoylmethyl)-3-trifluoromethyl benzamido-parachlorobenzyl 3-aminopyrrolidine (Teijin...
Breastfeeding can be a vital way of acquiring passive immunity via the transfer antibodies from mother to breastfeeding infant. Recent evidence points fact that human milk contains immunoglobulins (Ig) against SARS-CoV-2 virus, either after natural infection or vaccination, but whether these resist enzymatic degradation during digestion in infant gastrointestinal (GI) tract indeed protect consumers remains inconclusive. Herein, we evaluated levels IgG, IgA, and secretory IgA (SIgA) spike...
Scorpion venom peptides are generally classified into two main groups: the disulfide bridged (DBPs), which usually target membrane-associated ion channels, and non-disulfide (NDBPs), a smaller group with multifunctional properties. In past decade, these have gained interest because most of them display functions that include antimicrobial, anticancer, haemolytic, anti-inflammatory activities. Our current study focuses on short (9–19 amino acids) antimicrobial linear scorpion peptides. Most...
Lactate dehydrogenase (LDH) is an enzyme that catalyzes the reversible conversion of lactate to pyruvate while reducing NAD+ NADH (or oxidizing NAD+). Due its central role in Warburg effect, LDH-A isoform has been considered a promising target for treating several types cancer. However, research on inhibitors targeting LDH-B still limited, despite enzyme's implication development specific cancer such as breast and lung This study aimed identify small-molecule compounds specifically inhibit...
Microbial physiology is a basic course taught throughout biomedical science disciplines. Students study the structure, growth, and metabolism of microorganisms often find it difficult to learn information, usually because they fail see wider applications. The current microbiology laboratory series describes how transform "cookbook" undergraduate an inquiry-based one by incorporating problem-based learning. students use food poisoning case that develops over seven experiments take on role...
The contribution of specific HLA Class II alleles in type 1 diabetes is determined by polymorphic amino acid epitopes that direct antigen binding therefore, along with conventional allele frequency analysis, epitope analysis can provide important insights into disease susceptibility. We analyzed the highly heterogeneous Cypriot population for class loci T1DM patients and controls we report first time their frequencies. Within our patient cohort identified a subgroup did not carry...
Abstract Human leucocyte antigen ( HLA ) compatibility is the main factor determining occurrence of graft‐ vs ‐host disease (GVHD) in patients. It has also been shown that minor histocompatibility differences as well genetic polymorphisms are not sequenced by standard methodology for typing can play a role. We used mixed lymphocyte cultures (MLCs) functional cellular test and investigated gene expression changes driven incompatibility an effort to better understand mechanisms involved...
Monitoring the levels of IgG antibodies against SARS-CoV-2 is important during coronavirus disease 2019 (COVID-19) pandemic, to plan an adequate and evidence-based public health response. After this study we report that plasma spike protein were higher in individuals with evidence prior infection who received at least one dose either mRNA-based vaccine (Comirnaty BNT162b2/Pfizer-BioNTech or Spikevax mRNA-1273/Moderna) adenoviral-based (Vaxzervia ChAdOx1 nCoV-19 /Oxford-Astra Zeneca) (n = 39)...
Abstract Four vaccines have been approved to date by the European Medicines Agency for management of COVID-19 pandemic in Europe, with all four being targeted adults over 18 years age. One way protect younger population such as infants or children until pediatric are licensed is through passive immunity via breastfeeding. Recent evidence points fact that human milk contains immunoglobulins (Ig) against SARS-CoV-2 virus, both after natural infection vaccination, but it not known whether these...