A5086081901- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- Advanced Cellulose Research Studies
- Nanoparticle-Based Drug Delivery
- Bee Products Chemical Analysis
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Parasites and Host Interactions
- Electrospun Nanofibers in Biomedical Applications
- Polysaccharides and Plant Cell Walls
- Essential Oils and Antimicrobial Activity
- Polysaccharides Composition and Applications
- Bone Tissue Engineering Materials
- Curcumin's Biomedical Applications
- Ocular Surface and Contact Lens
- Skin Protection and Aging
- Hydrogels: synthesis, properties, applications
- biodegradable polymer synthesis and properties
- Wound Healing and Treatments
- RNA Interference and Gene Delivery
- Hepatitis Viruses Studies and Epidemiology
- Microencapsulation and Drying Processes
- Drug-Induced Hepatotoxicity and Protection
- Amoebic Infections and Treatments
National Research Centre
2016-2025
Ain Shams University
1979-2022
IBM (Egypt)
2021
Jazan University
2015
Alexandria University
2015
Pharmaceutical Biotechnology (Czechia)
2013
Tanta University
2011
Walter Reed Army Institute of Research
1982
Uniformed Services University of the Health Sciences
1982
Case Western Reserve University
1979-1980
Anorectal diseases, such as hemorrhoids, are bothersome benign conditions that warrant special attention. The design of an optimized vesicular system for localized rectal delivery can be a suitable conservative treatment. feasibility preparing proniosomes using different types Gelucires®, in combination with Span(®) 60 binary mixtures nonionic surfactants, was checked, then the prepared Span or 60/Gelucire were compared to conventional niosomes through investigations comprising following:...
Abstract The use of (PEG)-grafted materials has a positive impact on drug delivery. In this study we designed PEGylated lipid nanocarriers (PLN) loaded with curcumin (Cur) to target skin cancer by photodynamic therapy. Cur is polyphenolic compound having vast biological effects masked due its low aqueous solubility. PLN were prepared using Tefose 1500 different surfactants. PLN3, containing Tween 80, had the smallest particle size (167.60 ± 15.12 nm), Z = − 26.91 mV and, attained highest...
Poor aqueous solubility of chemical entities presents a major challenge to modern drug delivery, because their low bioavailability. Our aim was prepare and evaluate suitable solid self-emulsifying delivery system (SSEDDS) as potential carrier for rutin. After screening various vehicles (surfactants, co-surfactants oils) selection those having the better solubilizing power, liquid SEDDS were formulated. Prepared formulations evaluated ability phase diagrams constructed optimize systems....
This study was aiming to improve the effect of water-insoluble drug, resveratrol, by encapsulating it in surfactant-based elastic vesicles (spanlastics). Spanlastics (SLs) were prepared thin film hydration method using different ratios Span 60 (S60) and edge activators (EAs). The SLs subjected full in-vitro evaluation. All showed improved properties compared drug suspension (p < 0.05). SL5 composed S60: Brij 35 (7:3) attained highest entrapment efficiency (79.10%±5.56), smallest particle...
The GC-MS analysis of tea tree oil (TTO) revealed 38 volatile components with sesquiterpene hydrocarbons (43.56%) and alcohols (41.03%) as major detected classes. TTO efficacy is masked by its hydrophobicity; nanoencapsulation can address this drawback. results showed that TTO-loaded solid lipid nanoparticles (SLN1), composed glyceryl monostearate (2% w/w) Poloxamer188 (5% w/w), was spherical in shape a core-shell microstructure. TTO-SLN1 high entrapment efficiency (96.26 ± 2.3%), small...
Splenic suppressor cell activity was evaluated in 10 patients with advanced hepatosplenic Schistosomiasis mansoni undergoing elective splenectomy. We used mixing experiments to assess the effect of mitomycin-C-treated spleen cells on antigen and mitogen-induced 3H-thymidine incorporation responder cells. The ratio 1.0. Spleen from 7 caused at least 20% suppression phytohemagglutinin-induced one or more populations (spleen cells, autologous allogeneic peripheral blood mononuclear...