A5019610738- Neuroscience and Neuropharmacology Research
- Retinal and Macular Surgery
- Alcohol Consumption and Health Effects
- Plant-based Medicinal Research
- Neuroscience of respiration and sleep
- Pain Mechanisms and Treatments
- Neurological Disorders and Treatments
- Ocular Surface and Contact Lens
- Retinal Development and Disorders
- Corneal Surgery and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Alcoholism and Thiamine Deficiency
- Amino Acid Enzymes and Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Corneal surgery and disorders
- Pharmacogenetics and Drug Metabolism
Helmholtz Moscow Research Institute of Eye Diseases
2023
V.A. Negovsky Scientific Research Institute of General Reanimatology
2019-2022
Introduction. Idiopathic epiretinal membrane is a formation of fibrous cellular tissue in the macula. To our understanding there no data on interaction structures with each other, as well relationship them inner limiting membrane. The morphology latter during idiopathic has been scarcely studied due to absence specific immunohistochemical markers. We focused localizing and exploring components determining markers that allow identification membranes samples. Materials methods. analyzed 29...
Purpose: identification of pathological changes in the liver at early stages effect clozapine and combined with ethanol to improve diagnosis this acute exposure. Materials methods. The experiments were carried out on outbred male rats ( n =15). animals split into 3 groups, 5 each: 1) control (intact rats); 2) clozapine, 3) ethanol. Clozapine a dose 150 mg/kg animal’s body weight was administered orally under anesthesia (chloralose), (150 mg/kg) ml/kg — orally. Rats removed from experiment...
Актуальность. Авторами данной статьи представлен новый способ препарирования мембран, отличительной особенностью которого является формирование ультратонких срезов исследуемого препарата, что позволяет более детально изучить строение эпиретинальных и внутренних пограничных удаляемых с поверхности сетчатки при хирургическом вмешательстве по поводу эпиретинального фиброза. Цель. Представить ультраструктурные особенности удаленных в ходе хирургического вмешательства мембран использованием новой...
Objectives. Systematization of cerebellar Purkinje cell injuries to clarify the pathogenesis combined clozapine-alcohol poisoning and substantiate immediate cause death. Material methods. Experimental studies were performed on 25 white outbreed rats divided into 5 groups: control, group I (clozapine 3 hours), II 24 III + alcohol IV (clozapine+alcohol hours). Te assessment injury was using classifcation neuronal damage.Results. In control animals reversible changes in cells prevailed: primary...
Baclofen (sold under the name Baclosan©, Lioresal©) is a muscle relaxant. This drug chemically different from other relaxants. Due to its pronounced psychotropic effect often subject of abuse especially among young people. The article deals with dynamics lung histopathology in acute baclofen poisoning. Experimental studies were performed on 15 Wistar rats. animals divided into 3 groups (the controls and two experimental groups). included 5 intact Each group animals. Both treated at dosage 85...
A generic Baclofen, also known under the brand name of Lioresal, is a derivative gamma-aminobutyric acid. Due to its psychotropic effect it often used as drug abuse and for criminal poisoning. An experimental study was carried out on 5 Wistar rats (versus intact control group) exposed combined Baclofen (at dose 85 mg/kg) ethanol (7 ml/kg 40% ethanol) We have identified complex pathological changes in lungs early period after experiment. The outcomes included circulatory disorders pulmonary...
BACKGROUND: The number of poisoning with a muscle relaxant baclofen has increased recently. brain is one the target organs in poisoning.
 AIM: To identify and quantify cerebral cortex neuron damage ethanol MATERIAL AND METHODS: A histological study rat was performed. controls (n = 5) received neither nor ethanol. Groups 1 3 (85 mg/kg), whereas groups 2 4 mg/kg) (7 ml/kg). were euthanized h after drug administration, 24 h. Histological sections stained hematoxylin eosin by Nissl method...
BACKGROUND: The search for an effective method the treatment of limbal stem cell deficiency various etiologies, leading to intense clouding and vascularization cornea, followed by a significant decrease in visual acuity, remains important relevant topic ophthalmology. results studies showed that transplantation buccal epithelial cells could significantly improve prognosis this category patients.
 AIM: To determine optimal fixation period combined bioconstruction with experiment.
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Clozapine is an atypical neuroleptic with a narrow therapeutic index which widely used in clinical practice. Due to its psychotropic effect the drug often misused. Experimental studies were performed on 25 outbreed mail rats. The animals divided into 5 groups (the controls and four experimental groups). included intact 1 2 treated clozapine at dose 150 mg/kg. 3 4 received same ethanol (2 ml/kg 70% ethanol). Severe damage Purkinje cells of cerebellum was confirmed by increase number neurons...