A5101430995- Neurological Disease Mechanisms and Treatments
- Neurological Disorders and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal plant effects and applications
- Biological Activity of Diterpenoids and Biflavonoids
- Food Supply Chain Traceability
- Cleft Lip and Palate Research
- Insect-Plant Interactions and Control
- Plant and Fungal Interactions Research
- Technology and Security Systems
- Plant Virus Research Studies
- Natural product bioactivities and synthesis
- Genomics, phytochemicals, and oxidative stress
- Bioactive Compounds in Plants
- Craniofacial Disorders and Treatments
- Wireless Sensor Networks and IoT
- Hedgehog Signaling Pathway Studies
- Immune Response and Inflammation
First Affiliated Hospital of Gannan Medical University
2018-2025
First Affiliated Hospital of Jiangxi Medical College
2024-2025
Jiangxi Provincial People's Hospital
2024-2025
Gannan Medical University
2024
China Agricultural University
2022
Mudanjiang Medical University
2011
Ischemic stroke (IS) is an important cause of death worldwide. Dihydromyricetin (DHM) has been reported to have neuroprotective potential, but its role and mechanism in IS not fully elucidated. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was used determine the safe dose DHM BV2 microglia applicability OGD/R-treated cells. action explored by RT-qPCR, ELISA, luciferase reporter gene western blotting. dose-dependently enhanced cell viability post-OGD/R...
Objective: Orofacial clefts (OFCs) are the most common congenital craniofacial anomalies worldwide. However, data on burden and trends of this disease remains limited. Methods: This study utilizes from 2021 Global Burden Disease to analyze prevalence, incidence, disability-adjusted life years 1990 at global, regional, national levels, along with age-standardized rates average annual percentage change. In addition, authors examine these global by age, gender, Sociodemographic Index (SDI)....
The learning and memory impairment caused by chronic cerebral hypoperfusion (CCH) is permanent seriously affects the daily life of patients their families. compound 3'-daidzein sulfonate sodium (DSS) protects against CCH-mediated hippocampal damage in a rat model. In present study, we investigated further underlying mechanisms this effect two-vessel occlusion (2VO) oxygen glucose deprivation (OGD) primary neuron models. expression activity-regulated cytoskeleton associated protein (Arc)...
Grapevine leafroll-associated virus 2 (GLRaV-2) is a prevalent associated with grapevine leafroll disease, but the molecular mechanism underlying GLRaV-2 infection largely unclear. Here, we report that 24-kDa protein (p24), an RNA-silencing suppressor (RSS) encoded by GLRaV-2, promotes accumulation via interaction B3 DNA-binding domain of (Vitis vinifera) RELATED TO ABSCISIC ACID INSENSITIVE3/VIVIPAROUS1 (VvRAV1), transcription factor belonging to APETALA2/ETHYLENE RESPONSE FACTOR (AP2/ERF)...
Ischemic stroke (IS) remains a leading cause of disability and mortality worldwide, inflammation oxidative stress play significant roles in its pathogenesis. This study investigates the effects dihydromyricetin (DHM) on IS using RT-qPCR western blot with SH-SY5Y cells, focusing small nucleolar RNA host gene 10 (SNHG10)/microRNA (miR)-665/Ras association domain family member 5 (RASSF5) axis nuclear factor-kappa B (NF-κB) signaling. In addition, SNHG10/miR-665/RASSF5 cell activity, apoptosis,...
3'-Daidzein sulfonate sodium (DSS) is a new synthetic water-soluble compound derived from daidzein, soya isoflavone that plays regulatory roles in neurobiology. In this study, we hypothesized the role of DSS neurobiology exhibits therapeutic effects on hippocampal damage and memory impairment. To validate hypothesis, established rat models chronic cerebral hypoperfusion (CCH) by permanent occlusion common carotid arteries using two-vessel method. Three weeks after modeling, were...
PYNOD, a nod-like receptors (NLR)-like protein, was indicated to inhibit NF-κB activation, caspase-1-mediated interleukin (IL)-1β release and cell apoptosis in dose-dependent manner. Exogenous addition of recombinant PYNOD mixed glial cultures may suppress caspase-1 activation IL-1β secretion induced by Aβ. However, the best our knowledge, there no study has focused on immunoregulatory effects specifically microglia. The present aimed explore roles involved lipopolysaccharides (LPS)-induced...
Background: Orofacial clefts represent the most prevalent form of craniomaxillofacial deformity. Genetic factors are particularly significant in development orofacial clefts. This study was to investigate genetic variation patients with Methods: is a retrospective descriptive study. Whole-exome sequencing (WES) conducted identify mutated genes and mutation loci The identified validated through Sanger sequencing. Furthermore, functional analysis gene performed by utilizing comprehensive...