A5102950394- Muscle metabolism and nutrition
- Exercise and Physiological Responses
- Muscle Physiology and Disorders
- Nutrition and Health in Aging
- Cancer survivorship and care
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Chemotherapy-induced cardiotoxicity and mitigation
- Human-Animal Interaction Studies
- Childhood Cancer Survivors' Quality of Life
- Adipokines, Inflammation, and Metabolic Diseases
- Antibiotic Resistance in Bacteria
- Cerebral Palsy and Movement Disorders
- Cancer, Hypoxia, and Metabolism
- Cardiovascular and exercise physiology
- Telomeres, Telomerase, and Senescence
- Autophagy in Disease and Therapy
- Genetic Neurodegenerative Diseases
- Rabies epidemiology and control
- Genetics and Physical Performance
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Peripheral Artery Disease Management
- Lymphatic System and Diseases
- Sports Performance and Training
Universidade Estadual de Londrina
2016-2025
Ospedali Riuniti di Foggia
2015
While chemotherapy treatment can be lifesaving, it also has adverse effects that negatively impact the quality of life. To investigate doxorubicin on body weight loss, strength and muscle mass physical function impairments, all key markers cachexia, sarcopenia, frailty. Seventeen C57/BL/6 mice were allocated into groups. 1) Control (n = 7): exposed to intraperitoneal (i.p.) injections saline solution. 2) Dox 10): cycles (total dose 18 mg/kg divided over 15 days). The loss decreased food...
Creatine has demosntrated protective effects against muscle dysfunction, but its potential protection doxorubicin-induced cardio and skeletal toxicity remains poorly understood. We aimed to investigate the of creatine supplementation myotoxicity. This study analyzed twenty male C57BL/6J mice, divided into three groups: Control (C; n = 6), Dox (n 7) which received weekly doxorubicin injections (16 mg/kg i.p. in 20 days) DoxCr with both (4%). Doxorubicin administration induced atrophy extensor...
Muscle wasting has been emerging as one of the principal components cancer cachexia, leading to progressive impairment work capacity. Despite early stages melanomas rarely promotes weight loss, appearance metastatic and/or solid tumor melanoma can leads cachexia development. Here, we investigated B16F10 tumor-induced and its contribution muscle strength locomotor-like activity impairment. C57BL/6 mice were subcutaneously injected with 5 x 104 cells or PBS a Sham negative control. Tumor...
The main aim of this study was to investigate the moderate versus high-load resistance training on muscle strength, hypertrophy and protein synthesis signaling in rats. Twenty rats were randomly allocated into three groups as follow: control group (C, n = 6), (HL, 7) moderate-load (ML, 7). A ladder climb exercise used mimic exercise. ML consisted a load, allowing performance at higher volume load inherent number repetitions (8-16 climbing). HL progressively increase with low (4-8 C remained...
Although the role of signal transducers and activators transcription (STAT3) in cachexia due to association circulating IL-6 muscle wasting has been extensively demonstrated, effect resistance training on STAT3 mediating atrophy tumor-bearing mice is unknown. The aim this study investigate effects exercise inflammatory cytokines oxidative-mediated activation loss prevention mice.Male Swiss were inoculated with Ehrlich tumor cells exposed or not protocol ladder climbing. Skeletal protein...
We tested the hypothesis that creatine supplementation may potentiate exercise’s protective effects against doxorubicin-induced hepatotoxicity. Thirty-eight Swiss mice were randomly allocated into five groups: control (C, n = 7), exercised (Ex, treated with doxorubicin (Dox, 8), and (DoxEx, doxorubicin, exercised, supplemented (DoxExCr, 8). Doxorubicin was administered weekly (i.p.) for a total dose of 12 mg/kg. Creatine (2% added to diet) strength training (climbing stairs, 3 times week)...
This study aimed to determine the role of mammalian target rapamycin (mTORC1) activation and catabolic markers in resistance training's (RT) antiatrophy effect during cachexia-induced muscle loss.Myofiber atrophy was induced by injecting Walker 256 tumor cells into rats exposed or not RT protocol ladder climbing. The RT-induced anabolic stimulation investigated tumor-bearing with mTORC1 inhibitor rapamycin, cross-sectional areas skeletal were evaluated identify hypertrophy. Components...
The aim of this study was to investigate the effects creatine supplementation on early stages ethanol-induced hepatic damage. Male Swiss mice were divided into three groups (n = 12/group): control (C), ethanol (E), and supplemented with (EC). group received a diet containing 15.8% total calories from proteins, 46.3% carbohydrates, 37.9% lipids. diets 16.2% 34.5% lipids; remaining obtained addition 5% 95% ethanol. Creatine (1%; weight/vol) added EC mice. After 14 28 d, six animals each...
<em>Background</em>. Resistance to carbapenems in <em>Klebsiella</em> <em>pneumoniae</em> infections could compromise therapy efficiency hospitals. In Italy, the percentage of <em>K</em>. <em>pmeumoniae</em> resistant blood-isolated is 35%. <br /><em>Materials</em> <em>and</em> <em>Methods</em>. Seventy-three multidrug-resistant clinical isolates coming from Foggia (Italy) have been...
Dogs from the beginning of their domestication serve man as a tool for hunting, herding, guard, company and currently psychological therapies, fact that denotes its importance multifunctionality in modern societies. Despite animal protection laws have been recently updated, defining mistreat crimes, an awareness owner is still necessary because lack information produces population without control, which animals are sacrificed or abandoned on streets by it’s owners, increasing risk zoonoses...