A5102021895- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Membrane Separation Technologies
- Immunotherapy and Immune Responses
- Advanced Measurement and Detection Methods
- Advanced oxidation water treatment
- Wastewater Treatment and Reuse
- Neurological Disease Mechanisms and Treatments
- Ferroptosis and cancer prognosis
- Metastasis and carcinoma case studies
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Brain Metastases and Treatment
- Colorectal Cancer Treatments and Studies
- Water Treatment and Disinfection
- Esophageal and GI Pathology
- Cancer Diagnosis and Treatment
- Polyomavirus and related diseases
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Viral-associated cancers and disorders
- Image Processing Techniques and Applications
- Atherosclerosis and Cardiovascular Diseases
First Affiliated Hospital of Zhengzhou University
2021-2025
Xiangyang Hospital of Traditional Chinese Medicine
2020-2024
Hubei University of Chinese Medicine
2020-2024
Sichuan University
2008-2024
Huzhou University
2024
The First Hospital of Kunming
2024
Universitat Politècnica de València
2023
State Key Laboratory of Biotherapy
2020-2022
West China Medical Center of Sichuan University
2001-2022
Xi'an Peihua University
2021
Patients with advanced non-small cell lung cancer (NSCLC) are prone to brain metastases (BM), which essentially include parenchymal (PM) and leptomeningeal (LM). We conducted a retrospective study comprehensively assess the clinical characteristics risk factors of patients NSCLC who develop PM LM. were enrolled. These then divided into three groups for analysis: without BM (No-BM), Data on each patient at time diagnosis extracted analyzed. In addition, prediction models developed evaluated A...
Objective Gastric cancer is the fifth most common worldwide and third leading cause of cancer-related deaths. Insulin-like growth-factor-binding proteins (IGFBPs) were initially identified as passive inhibitors that combined with insulin-like growth factors (IGFs) in serum. However, more recent data have shown they different expression patterns a variety functions development occurrence cancers. Thus, their various roles still need to be elucidated. This study aimed explore IGFBPs prognostic...
Immune checkpoint inhibitors (ICIs) combined with chemotherapy have become a standard first-line treatment for advanced non-small cell lung cancer (NSCLC). However, the optimal sequence of administrating two treatments remains controversial. This study included NSCLC patients who received ICIs at Renmin Hospital Wuhan University and Xiangyang Hospital, Hubei Chinese Medicine between 1st September 2020 30th 2024. Patients were categorized into concurrent, immune-chemo, chemo-immune groups...
Ultrafiltration is a promising, environment-friendly alternative to the current physicochemical-based tannery wastewater treatment. In this work, ultrafiltration was employed treat tanning as an upstream process of Zero Liquid Discharge (ZLD) system in leather industry. The filtration efficiency and fouling behaviors were analyzed assess impact membrane material operating conditions (shear rate on surface transmembrane pressure). models resistance-in-series, propensity, pore blocking used...
Situs inversus totalis (SIT) is a very rare congenital condition. patients who present with gastric cancer have been reported in Japan, China, the United States, and other countries. China has high incidence of cancer, accounting for 40% global annual incidence. Surgical treatment options situs are great concern due to nature condition anatomical variations. This case aims demonstrate utility robotic surgery treating cancer. We report 69-year-old male patient successfully underwent DaVinci...
The purpose of the present study was to obtain information on use PD-1/PD-L1 inhibitors by oncologists in China through a national questionnaire survey.Between 7th and 25th July 2019, designed Chinese Society Clinical Oncology Immuno-Oncology (CSCO IO) Committee current status distributed online offline cancer-related medical departments thirty different provinces autonomous regions China. consisted three sections as follows: general information, application clinic, oncologists' concerns...
Immune checkpoint inhibitors (ICIs) have improved the long-term survival of NSCLC patients. However, efficacy ICIs in elderly patients remains controversial. We conducted a retrospective study and meta-analysis exploring those using public databases RCTs. were identified into non-elderly groups by age 75 years. The showed significant differences OS PFS between treated with (P= 0.029 0.027), reduced ECOG PS also negatively affected 0.007). In meta-analysis, HR for 0.74 0.90, respectively,...
Triple-negative breast cancer (TNBC) is usually poorly differentiated, highly invasive, susceptible to distant metastasis, and less responsive endocrine targeted therapy. However, immunotherapy a promising treatment for TNBC patients recently.The prognostic value of immune-related genes (IRGs) was explored by using RNA sequencing microarray data 123 107 from TCGA GEO databases, respectively.In database, GO KEGG pathway analysis 119 differential IRGs indicated that they actively participate...
Targeted therapy has been established as the standard-of-care for patients with advanced non-small cell lung cancer (NSCLC) epidermal growth factor receptor (EGFR) mutations. Among cancer, 30-40% have bone metastases (BoM) at first diagnosis. However, little is known on clinical characteristics and prognostic factors of BoM in NSCLC harboring EGFR mutations.Treatment-naive mutations who were prescribed tyrosine kinase inhibitors (TKIs) screened enrolled between June 2009 April 2019 from West...
Currently, the predictive role of POLE mutations for immunotherapy is under intense investigation. The gene encodes one four subunits DNA polymerase important replication and repair. are related to other favorable predicative factors such as high expression PD-L1, TMB, infiltration CD8+ cells in tumor microenvironment. No formal clinical trials studied efficacy lung patients harboring mutation, only few cases were mentioned literature. Moreover, cancer prone brain metastasis, which notorious...
Leptomeningeal metastases (LM) is the end-event of lung cancer and prognosis dismal. Few studies explored prognostic performance systematic immunological levels in patients with LM. Our study aimed to explore possible relationship between LM level other clinical characteristics.This retrospective, multi-institutional, observational was conducted 4 tertiary centers China. Patients were screened from January 2009 May 2019. radiographically or histologically confirmed enrolled. The data...
Epithelial-mesenchymal transition (EMT) is significantly associated with the invasion and development of esophageal squamous cell carcinoma (ESCC). However, importance EMT-related long noncoding RNA (lncRNA) little known in ESCC. GSE53624 (N = 119) GSE53622 60) datasets retrieved from Gene Expression Omnibus (GEO) database were used as training external validation cohorts, respectively. all sampled China. Then, prognostic value lncRNA was comprehensively investigated by weighted coexpression...
Background Monoclonal antibodies against programmed cell death protein-1 (PD-1)/programmed death-ligand-1 (PD-L1) have emerged as critical tools in cancer treatment. However, concerns regarding their potential cutaneous and mucosal toxicity, along with severe complications, drawn clinical attention. Further research is warranted to investigate the adverse reactions treatment strategies associated PD-1 monoclonal antibodies. Methods We present a detailed case report of laryngeal patient who...
The quantification of centipede populations is one the key measures in achieving intelligent management edible centipedes and promoting upgrade rural industry chain. However, current counting techniques still face several challenges, including low detection accuracy, large model size, difficulty deployment on mobile devices. These challenges have limited existing network models to experimental stage, preventing their practical application. To tackle identified this study introduces a...