Iradj Sobhani

ORCID: 0000-0003-1031-0080
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About
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Research Areas
  • Colorectal Cancer Surgical Treatments
  • Colorectal Cancer Screening and Detection
  • Colorectal Cancer Treatments and Studies
  • Pelvic floor disorders treatments
  • Regulation of Appetite and Obesity
  • Gastric Cancer Management and Outcomes
  • Esophageal and GI Pathology
  • Chemokine receptors and signaling
  • Pancreatic and Hepatic Oncology Research
  • Anorectal Disease Treatments and Outcomes
  • Colorectal and Anal Carcinomas
  • Genetic factors in colorectal cancer
  • Biochemical Analysis and Sensing Techniques
  • Gastrointestinal disorders and treatments
  • Adipokines, Inflammation, and Metabolic Diseases
  • Diverticular Disease and Complications
  • Clostridium difficile and Clostridium perfringens research
  • Dietary Effects on Health
  • Academic Writing and Publishing
  • Helicobacter pylori-related gastroenterology studies
  • Biomedical Research and Pathophysiology
  • Sympathectomy and Hyperhidrosis Treatments
  • Eosinophilic Esophagitis
  • Diabetes Treatment and Management
  • Glycogen Storage Diseases and Myoclonus

Hôpitaux Universitaires Henri-Mondor
2008-2023

Université Paris-Est Créteil
2010-2023

Assistance Publique – Hôpitaux de Paris
2008-2023

Inserm
1993-2023

Centre Hospitalier Universitaire de Clermont-Ferrand
2021

Paris-Est Sup
2016-2019

Centre Hospitalier Universitaire Henri-Mondor
2011-2016

Hôpital Albert-Chenevier
2010

Université Paris Cité
2010

Hôpital Bichat-Claude-Bernard
1993-2002

<h3>BACKGROUND AND AIM</h3> The circulating peptide leptin produced by fat cells acts on central receptors to control food intake and body weight homeostasis. Contrary initial reports, expression has also been detected in the human placenta, muscles, recently, rat gastric chief cells. Here we investigate possible presence of receptor stomach. <h3>METHODS</h3> Leptin were assessed immunohistochemistry, reverse transcriptase-polymerase chain reaction (RT-PCR), western blot analysis biopsy...

10.1136/gut.47.2.178 article EN Gut 2000-08-01

<h3>Hypothesis</h3> The more rapid and less complicated recovery after palliative stent insertion compared with surgery may theoretically facilitate the early administration of chemotherapy. <h3>Design</h3> A retrospective study. <h3>Setting</h3> University tertiary care referral center. <h3>Patients</h3> From January 1, 1996, to September 15, 2005, 58 patients obstructing colon cancer nonresectable synchronous metastases were treated self-expanding colonic metallic (SEMS) (n = 31) or 27)....

10.1001/archsurg.142.7.619 article EN Archives of Surgery 2007-07-01

Background: Minimally invasive surgery in elderly patients with colorectal cancer remains controversial. The study aimed to compare the operative, postoperative, and oncologic outcomes of robotic (robotic resection [RCRS]) versus laparoscopic (LCRS) cancer. Methods: Propensity score matching (PSM) was used aged 70 years more undergoing elective RCRS or LCRS for between 2010 2017. Results: Overall, 160 underwent curative (n = 102) 58) Before PSM, mean preoperative Charlson tumor size were...

10.1089/lap.2018.0115 article EN Journal of Laparoendoscopic & Advanced Surgical Techniques 2018-05-31

Abstract We have shown that ObRb, the leptin receptor, is overexpressed in colorectal cancer cells, and this may influence patients' outcome. investigated colonocytes as targets characterized their pivotal role antitumor immune response. Cytokine chemokine mRNAs HT29 cells were measured by targeted arrays. In vitro, normal human colon (HT29, Caco-2, SW480, HCT116) used to investigate ObRb transduction system cytokine releases. Animal CD8 splenocytes HT29, HCT116, CD8+ from blood donors...

10.1158/0008-5472.can-08-1017 article EN cc-by Cancer Research 2008-11-14

For more than two decades, an increased interest in understanding relationship between obesity and cancer is observed the medical literature.However, epidemiological data remain heterogeneous depending on site, age, gender, type of tissue adipose (visceral, subcutaneous) ethnicity: linked with a greater risk colo-rectal (CRC) for men all ages premenopausal women.Mechanisms involved are not fully investigated: no specific genetic marker linking identified, except few metabolic markers,...

10.2174/1876823701002010038 article EN The Open Obesity Journal 2010-01-01
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