A5089963710- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Pulmonary Hypertension Research and Treatments
- Cell Adhesion Molecules Research
- interferon and immune responses
- Thermal Regulation in Medicine
- Single-cell and spatial transcriptomics
- Mitochondrial Function and Pathology
The Ohio State University
2024
National Institute on Aging
2022-2023
National Institutes of Health
2022-2023
Purdue University West Lafayette
2022
Frailty, a clinical syndrome commencing at midlife, is risk for morbidity and mortality. Little known about the factors that contribute to chronic inflammatory state associated with frailty. Extracellular vesicles (EVs) are small, membrane-bound released into circulation mediators of intercellular communication. We examined whether mitochondrial DNA (mtDNA) proteins in EVs may act as damage-associated molecular pattern (DAMP) molecules frailty.To address their mtDNA protein cargo altered...
Circulating cell-free mitochondrial DNA (ccf-mtDNA) acts as a damage-associated molecular pattern molecule and may be cargo within extracellular vesicles (EVs). ccf-mtDNA select (mtDNA) haplogroups are associated with cardiovascular disease. We hypothesized that plasma EV mtDNA would hypertension, sex, self-identified race, haplogroup ancestry. Participants were normotensive (n = 107) hypertensive 108) African American White adults from the Healthy Aging in Neighborhoods of Diversity across...
Abstract Extracellular vesicles (EVs) released from non-small cell lung cancer (NSCLC) cells are known to promote progression. However, it remains unclear how EVs various NSCLC differ in their secretion profile and ability phenotypic changes non-tumorigenic cells. Here, we performed a comparative analysis of EV release (HBEC/BEAS-2B) several lines (A549, H460, H358, SKMES, Calu6) evaluated the potential impact EVs, including EV-encapsulated RNA (EV-RNA), driving invasion epithelial barrier...
Abstract Tertiary Lymphoid Structures (TLSs) are ectopic lymphoid structures that form in chronically inflamed non-lymphoid tissue. The presence of TLSs tumors is largely associated with favorable outcomes among patients and also exhibit positive associations response to immune checkpoint blockade. Although mainly comprised lymphocytes (B cells T cells), they considered a separate entity from lymphocyte aggregates within Lymphocyte fairly routine identify H&E stained tissue sections, but...