A5072280596- Ocular Surface and Contact Lens
- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Immune Cell Function and Interaction
- Ocular Infections and Treatments
- Neuropeptides and Animal Physiology
- Pediatric health and respiratory diseases
- Trigeminal Neuralgia and Treatments
- Immunotherapy and Immune Responses
- melanin and skin pigmentation
- Corneal Surgery and Treatments
- Transgenic Plants and Applications
- Urticaria and Related Conditions
- Migraine and Headache Studies
- Asthma and respiratory diseases
- Immune Response and Inflammation
- Inflammasome and immune disorders
- T-cell and B-cell Immunology
- Mast cells and histamine
- Skin Protection and Aging
University Hospital Bonn
2020-2023
Instituto Politécnico Nacional
2013-2015
Center for Research and Advanced Studies of the National Polytechnic Institute
2012-2014
Allergic conjunctivitis (AC) is one of the most common eye disorders in ophthalmology. In mice models, it has been suggested that control allergic a delicate balance between Tregs and inflammatory migrating effector cells. Our aim was to evaluate frequency homing receptors expressing cells peripheral blood mononuclear (PBMC) from patients with perennial (PAC). The analyses phenotypic markers on CD4+ T both soluble or intracellular cytokines were performed by flow cytometry. CD4+CD25+ 15...
Background: Dialyzable leukocyte extracts (DLE) are heterogeneous mixtures of peptides less than 10 kDa in size that used as immunomodulatory adjuvants immune-mediated diseases. TransferonTM is DLE manufactured by National Polytechnic Institute (IPN), and registered Mexican health-regulatory authorities an drug commercialized nationally. The proposed mechanism action induction a Th1 immunoregulatory response. Despite it widely used, to date there no reports adverse events related the...
Background: Atopic dermatitis (AD) is one of the most common inflammatory skin diseases, with an increasing incidence in clinical practice. AD models have demonstrated that TGF-β signaling compromised regulatory T cells (Tregs). Objectives: This study aimed to investigate TGF-β-dependent vitro conversion CD4+CD25– derived from AD-patients into CD4+CD25+Foxp3+ induced Tregs (iTregs) comparison healthy controls. Methods: To analyze iTreg conversion, human were cultured on anti-CD3-coated...
Atopic dermatitis (AD), a chronic inflammatory disorder, is often accompanied by allergic rhinoconjunctivitis (ARC) as co-morbidity. The use of monoclonal anti-IL-4Rα antibody has been effective in controlling moderate to severe AD symptoms. Allergen-specific immunotherapy (AIT) widely used for the treatment ARC and asthma. effects AIT on basophil reactivity/effector functions have already examined indicators efficacy. However, it unclear, how an can influence allergen-specific immune...
Abstract Allergic conjunctivitis (AC) is one of the most common eye disorders in ophthalmology. AC a disorder mediated by Th2 cells, where inflammation caused type I hypersensitivity. It has been suggested that some neuropeptides are increased (CGRP, SP and VIP) contributing to local damage. In other hand, α-MSH plays an immunomodulatory role ocular tissues; however, its allergic disease unknown, thus it was aim this study. Methods: Peripheral blood mononuclear cells (PBMC) were isolated...
Abstract Purpose: To evaluate frequency of T regulatory cells (Tregs) and homing receptor expression in patients with allergic conjunctivitis (AC). Methods: Peripheral blood mononuclear (PBMC) were isolated from healthy donors (HD) AC-patients labeled mAbs against CD4, CD25, FOXP3, CCR4, CCR5, CCR7, CCR9, CD103 CD108 before after antigen stimulation Dermatophagoides pteronyssinus (Der p). All analyzed by flow cytometry culture supernatants recovered to analyze IL-10 TGF-β. Results. showed...
Background It is well known involvement of CD4+ T cells in the maintenance allergic immune response at conjunctiva; recently, it was suggested mouse model that γδ are needed for ocular maintenance; however contribution human conjunctivitis still unknown. The aim this study to evaluate frequency AC patients.
Background Allergic conjunctivitis is one of the most common diseases affecting ocular surface, it has been suggested that T CD4+ cells regulate immune response in allergic such as asthma and rhinitis, a predominant Th2 response. In animal models, observed selective migration to conjunctiva directed by chemokines; however molecules involved cell humans unknown, thus was aim this study.
Background Allergic conjunctivitis (AC) is one of the most common eye disorders in clinical practice. It has been shown that AC a disorder mediated by Th2 lymphocytes producing IL-4 and IL-5, where damage caused type I hypersensitivity. suggested asthma rhinitis T regulatory cells (Tregs) CD4+ CD25+ FOXP3+ have involved control allergic status, favoring an optimal microenvironment with immunosuppressive cytokines (IL-10, TGF-β). However unknown if Tregs role human conjunctivitis, thus it...