A5081575577- Sleep and related disorders
- Childhood Cancer Survivors' Quality of Life
- Family Support in Illness
- Cancer survivorship and care
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Youth Substance Use and School Attendance
- COVID-19 and Mental Health
- Cancer-related cognitive impairment studies
- Homelessness and Social Issues
- Family and Disability Support Research
- Early Childhood Education and Development
- Acute Lymphoblastic Leukemia research
- Infant Development and Preterm Care
- Health and Wellbeing Research
- Impact of Technology on Adolescents
- Sexual function and dysfunction studies
- Hepatitis C virus research
- Patient-Provider Communication in Healthcare
- Menopause: Health Impacts and Treatments
- Attachment and Relationship Dynamics
- Obstructive Sleep Apnea Research
- Computational Drug Discovery Methods
- Adolescent and Pediatric Healthcare
- RNA Research and Splicing
Dana-Farber Cancer Institute
2016-2025
Harvard University
2016-2025
Henan University
2025
Shandong Provincial Hospital
2025
Case Western Reserve University
2023-2025
University School
2023-2025
Boston Children's Hospital
2016-2025
Cleveland Clinic
2018-2025
University of Auckland
2014-2025
Shandong University
2025
This guideline establishes clinical practice recommendations for the use of behavioral and psychological treatments chronic insomnia disorder in adults. The American Academy Sleep Medicine (AASM) commissioned a task force experts sleep medicine psychology to develop assign strengths based on systematic review literature an assessment evidence using Grading Recommendations Assessment, Development Evaluation (GRADE) methodology. evaluated summary relevant quality evidence, balance clinically...
<h3>Importance</h3> Black women are at risk for insomnia disorder. Despite interest in addressing sleep health disparities, there is limited research investigating the efficacy of criterion-standard treatment (cognitive behavioral therapy [CBT-I]) among this racial minority population. <h3>Objective</h3> To compare a standard version an internet-delivered CBT-I program, culturally tailored version, and education control improving symptoms. <h3>Design, Setting, Participants</h3> In...
ABSTRACT Background Insomnia is the most common sleep disturbance among cancer patients undergoing active treatment. If untreated, it associated with significant physical and psychological health consequences. Prior efforts to determine insomnia prevalence correlates have primarily assessed in clinical trials, limited disease groups, excluding important patient subgroups. These findings are likely be influenced by research participation effects, which could bias outcomes. We sought address...
Abstract Introduction Alzheimer's disease (AD) is a devastating condition with no effective treatments, promising findings in rodents failing to translate into successful therapies for patients. Methods Targeting the vulnerable entorhinal cortex (ERC), rhesus monkeys received two injections of an adeno‐associated virus expressing double tau mutation (AAV‐P301L/S320F) left hemisphere, and control AAV‐green fluorescent protein right ERC. Noninjected aged‐matched served as additional controls....
Abstract Objectives : There is evidence that cancer generates existential and spiritual concerns for both survivors caregivers, the survivor's well‐being (SWB) related to his/her own quality of life (QOL). Yet degree which SWB each member couple has an independent association with partner's QOL unknown. Thus, this study examined individual dyadic associations couples dealing cancer. Methods A total 361 married survivor–caregiver dyads participating in American Cancer Society's Study...
Breast cancer is a leading cause of death in women. Sleep has been linked with mortality among cancer-free population; however, its association survival women breast understudied. patients (N=3682) reported their average sleep duration post diagnosis. Subsamples also provided pre-diagnosis (n=1949) and post-diagnosis difficulties (n=1353). Multivariate Cox models estimated hazard ratios (HR) confidence intervals (CI) all-cause, cancer, non-breast mortality. At diagnosis, the mean age was...
Abstract Objective Sleep disorders are associated with psychological and physical health, although reports in long‐term survivors of childhood cancer limited. We characterized the prevalence risk factors for behaviors consistent sleep examined longitudinal associations emotional distress health outcomes. Methods Survivors (n = 1933; median [IQR] age 35 [30, 41]) siblings 380; 33 [27, 40]) from Childhood Cancer Survivor Study completed measures quality, fatigue, sleepiness. Emotional outcomes...
Abstract Objective : Coping with the physical and mental side effects of diagnosis treatment for advanced prostate cancer (APC) is a challenge both survivors their spousal caregivers. There gap in our current understanding dyadic adjustment process on marital satisfaction this population. The study sought to: (1) document levels health, satisfaction, (2) evaluate relationship between health understudied Methods APC who had undergone androgen deprivation therapy within past year caregiver...
Survivors of prostate cancer experience treatment-related physical side effects that can compromise emotional well-being for years post-treatment. There is limited research investigating how social support and the use coping may affect this population following treatment. The aim study was to investigate impact 2 after treatment in survivors localized who have received either radical prostatectomy or radiotherapy. Psychosocial disease-specific measures were administered an ethnically...
BACKGROUND Epidemiological studies have shown prostate cancer (PC) survivors are at an increased risk of suicide compared with the general population, but to authors' knowledge very little is known regarding what factors associated this risk. The current study examined prevalence suicidal ideation (SI) and its association treatment posttreatment physical emotional health in a cohort long‐term PC survivors. METHODS A total 693 (3‐8 years after diagnosis) completed mailed survey on...
Tenofovir alafenamide (TAF) has shown equivalent efficacy and improved safety profiles for patients with chronic hepatitis B (CHB) compared to tenofovir disoproxil fumarate (TDF). However, limited data are available its resistance profiles. In two clinical trials, 1,298 E antigen-positive -negative CHB were randomized 2:1 treated TAF (n = 866) or TDF 432). Baseline nucleos(t)ide analog substitutions in HBV polymerase/reverse transcriptase (Pol/RT) assessed using INNO-LiPA Multi-DR v2/v3....
Abstract Study Objective To assess whether perceived racial discrimination is associated with insomnia among Black women. Methods Data on everyday and lifetime racism symptoms were collected from questionnaires administered in the Women’s Health Study, an ongoing prospective cohort of women recruited 1995 across United States. In 2009, participants completed five questions frequency discriminatory practices daily life (everyday racism) six ever experiencing unfair treatment key institutional...
Abstract Background Insomnia is common among adolescent and young adult (AYA) cancer survivors. Cognitive‐behavioral therapy for insomnia (CBT‐I) considered the gold standard treatment. Standard CBT‐I was designed adults not adapted to unique medical, psychosocial, developmental needs of AYA survivors, which can exacerbate their insomnia. Further, vast majority centers do have a behavioral sleep medicine expert on staff. Our study objective examine efficacy an Internet‐delivered program that...
Abstract The genome can be divided into two spatially segregated compartments, A and B, which partition active inactive chromatin states. While constitutive heterochromatin is predominantly located within the B compartment near nuclear lamina, facultative marked by H3K27me3 spans both compartments. How epigenetic modifications, compartmentalization, lamina association collectively maintain architecture remains unclear. Here we develop Lamina-Inducible Methylation Hi-C (LIMe-Hi-C) to jointly...
Early intervention approaches for facilitating motor development in infants and children with Down syndrome have traditionally emphasised the acquisition of milestones. As increasing evidence suggests that milestones limited predictive power long-term outcomes, researchers shifted their focus to understanding underlying perceptual-motor competencies influence behaviour syndrome. This paper outlines a series studies designed evaluate nature extent impairments present 12 between ages 8-15...