A5044839976- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Lanthanide and Transition Metal Complexes
- Metal complexes synthesis and properties
- Magnetism in coordination complexes
- Metal-Catalyzed Oxygenation Mechanisms
- Molecular Sensors and Ion Detection
- Electron Spin Resonance Studies
- Advanced MRI Techniques and Applications
- Electrochemical Analysis and Applications
- Synthesis of Organic Compounds
- Vanadium and Halogenation Chemistry
- Phytochemical compounds biological activities
- Natural product bioactivities and synthesis
Auburn University
2021-2023
Isfahan University of Technology
2015
Previously prepared Mn(II)- and quinol-containing magnetic resonance imaging (MRI) contrast agent sensors for H2O2 relied on linear polydentate ligands to keep the redox-activatable quinols in close proximity manganese. Although these provide positive T1-weighted relaxivity responses that result from oxidation of quinol groups p-quinones, reactions weaken binding affinity ligands, promoting dissociation Mn(II) aqueous solution. Here, we report a new ligand,...
Abstract A highly water‐ and air‐stable Fe(II) complex with the quinol‐containing macrocyclic ligand H 4 qp4 reacts 2 O to yield Fe(III) complexes less chelating forms of that have either one or two para ‐quinones. The reaction increases T 1 ‐weighted relaxivity over four‐fold, enabling detect using clinical MRI technology. iron‐containing sensor differs from its recently characterized manganese analog, which also detects , in it is oxidation metal center, rather than ligand, primarily...
In the current work, we demonstrate ligand design concepts that significantly improve superoxide dismutase (SOD) activity of a zinc complex; catalysis is enhanced when two quinol groups are present in polydentate ligand. We investigate mechanism through which quinols influence and determine impact entirely removing chelating group from original hexadentate Our results suggest SOD mimicry with these compounds requires coordinates Zn(II) strongly both its oxidized reduced forms proceeds...
Manganese, iron, and zinc complexes with the macrocyclic quinol-containing ligand H 4 qp4 are highly active durable catalysts for dismutation of hydrogen peroxide but do not efficiently dismutate superoxide.
Motivation: Multinuclear contrast agents (CAs) may provide improved sensitivity and specificity for the detection/quantification of biomolecular processes. Goal(s): To develop a multinuclear 1H 19F agent that shortens T1 relaxation times both signals only when hydrogen peroxide (H2O2) is present. Approach: Developed CA: Fe(II)-F2H4qp4 -- an iron(II) complex with fluorinated quinol-containing macrocyclic ligand. This T1-shortening CA designed to activate in presence H2O2. Results: Initial...