A5008237657- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Bacteriophages and microbial interactions
- Bacterial Genetics and Biotechnology
- RNA and protein synthesis mechanisms
- vaccines and immunoinformatics approaches
- Calcium signaling and nucleotide metabolism
- Chronic Myeloid Leukemia Treatments
- Fuel Cells and Related Materials
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Tumors and Oncological Cases
- Genomic variations and chromosomal abnormalities
- Acute Myeloid Leukemia Research
- Nanoparticle-Based Drug Delivery
- Prenatal Screening and Diagnostics
- Medicinal Plant Pharmacodynamics Research
- Electrocatalysts for Energy Conversion
University of Ostrava
2020-2024
University Hospital Ostrava
2020-2023
International Burch University
2020
Abstract Extramedullary multiple myeloma (EMM) is an aggressive form of (MM). This study represents the most comprehensive next-generation sequencing analysis EMM tumors ( N = 14) to date, uncovering key molecular features and describing tumor microenvironment. We observed co-occurrence 1q21 gain/amplification MAPK pathway mutations in 79% samples, suggesting that these are crucial mutational events development. also demonstrated patients with mutated KRAS at time diagnosis have a...
Abstract Serum monoclonal immunoglobulin (Ig) is the main diagnostic factor for patients with multiple myeloma (MM), however its prognostic potential remains unclear. On a large MM patient cohort (n = 4146), we observe no correlation between serum Ig levels and survival, while amount of intracellular has strong predictive effect. Focused CRISPR screen, transcriptional proteomic analysis identify deubiquitinase OTUD1 as critical mediator synthesis, proteasome inhibitor sensitivity tumor...
Gene expression resulting in the generation of new proteins is a fundamental process critical for every living organism. Particularly eukaryotic cells, complex organization cell body requires fine-tuning step prior to de novo protein synthesis. To ensure proper localization, certain mRNAs possess unique signal sequence, which destinies translation apparatus specific organelle. Here we focus on mechanisms governing sequence-bearing mRNAs, encode targeted endoplasmic reticulum (ER). The...
Abstract Gene expression resulting in the generation of new proteins is a fundamental process critical for every living organism. Particularly eukaryotic cells, complex organization cell body requires fine-tuning step prior to de novo protein synthesis. To ensure proper localization, certain mRNAs possess unique signal sequence, which destinies translation apparatus specific organelle. Here we focus on mechanisms governing sequence-bearing mRNAs, encode targeted endoplasmic reticulum (ER)....
Topic: 13. Myeloma and other monoclonal gammopathies - Biology & Translational Research Background: Extramedullary disease (EMD) is an aggressive manifestation of multiple myeloma (MM), where MM plasma cells become independent the bone marrow (BM) microenvironment infiltrate tissues organs. The incidence EMD increasing associated with worse prognosis drug resistance. Importantly, molecular processes underpinning pathogenesis resistance extramedullary form are poorly understood. Therefore, we...
Abstract Background Noninvasive prenatal testing (NIPT) is the most recent modality widely used in diagnostics. Commercially available NIPT has high sensitivity and specificity for common fetal chromosomal aneuploidies. As future advancements sequencing technology are becoming promising more reliable, ability to detect beyond aneuploidies expand detection of submicroscopic genomic alterations, as well single-gene disorders might become possible. Case presentation Here we present a case...