A5014324758- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- COVID-19 Clinical Research Studies
- Frailty in Older Adults
- Nutrition and Health in Aging
- Respiratory Support and Mechanisms
- Pneumonia and Respiratory Infections
- Long-Term Effects of COVID-19
- Allergic Rhinitis and Sensitization
- SARS-CoV-2 and COVID-19 Research
- Inhalation and Respiratory Drug Delivery
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Pediatric health and respiratory diseases
- Thermal Regulation in Medicine
- Immune Response and Inflammation
- Insect and Pesticide Research
- COVID-19 and healthcare impacts
- Tuberculosis Research and Epidemiology
- Sarcoidosis and Beryllium Toxicity Research
- Obstructive Sleep Apnea Research
- Food Allergy and Anaphylaxis Research
- Nosocomial Infections in ICU
University of Tsukuba Hospital
2025
Showa University
2014-2023
Jikei University School of Medicine
2021
Coronavirus disease 2019 (COVID-19) is globally rampant, and to curb the growing burden of this disease, in-depth knowledge about its pathophysiology needed. This was an observational study conducted at a single center investigate serum cytokine chemokine levels COVID-19 patients, based on severity. We included 72 consecutive patients admitted our hospital from March 21 August 31, 2020. Patients were divided into Mild-Moderate I (mild) Moderate II-Severe (severe) groups severity...
Immunoglobulin (Ig) E is well-known to play a critical role in allergic diseases. We investigated the association between longitudinal change total IgE level and asthma control patients with adult asthma.For this retrospective study, 154 aged 21-82 years were recruited from allergy pulmonary units of Showa University Hospital. Data on changes over preceding 10 collected logarithmically transformed. Associations clinical characteristics including test (ACT) score, control, function test,...
Background During the coronavirus pandemic in 2019, deterioration of mental health was reported among healthcare workers. However, few studies have examined relationship between workers' and occupational stress settings during spread disease 2019 (COVID-19). This study aimed to identify job stressors associated with issues Methods The conducted from May 2020 January 2021. We analyzed impact on using nine-item Patient Health Questionnaire, seven-item Generalized Anxiety Disorder, Impact Event...
To avoid future risk is a definitive goal of long-term asthma management. Exacerbations are considered to be the most relevant in real life Few comparative studies have evaluated factors associated with exacerbations Japanese patients asthma.We performed prospective 1-year follow up study adult asthma. A total 189 were enrolled and followed for 1 year. Finally, 181 completed protocol.Of patients, 43 (23.8%) had during follow-up period. Among 45 who preceding year, 32 (71.1%) exacerbations....
Aim Frailty and sarcopenia affect the prognosis quality of life patients with chronic obstructive pulmonary disease (COPD). However, it remains uncertain which model is most suitable for evaluating vulnerability in COPD. We evaluated validity three frailty models – Kihon Checklist (KCL), Japanese version Cardiovascular Health Study Osteoporotic Fractures one older Methods This cross‐sectional study included 201 (aged ≥65 years) outpatients used to identify their correlation various indices...
Frailty is a poor prognostic factor in patients with chronic obstructive pulmonary disease (COPD). Although various studies have assessed the effects of conventional treatment bronchodilators, nutritional support, and rehabilitation for frailty COPD, none addressed traditional Japanese medicine (Kampo medicine). Herein, we report successful management using Ninjin'yoeito therapy 76-year-old patient COPD. Despite being prescribed multiple supplement therapy, education, rehabilitation,...
Objectives: Frail patients with chronic obstructive pulmonary disease (COPD) have a higher risk of mortality, mood disorder, and poor quality life (QOL). There are few intervention studies in frail COPD, there is need for an effective therapy. Ninjin'yoeito (NYT) Kampo medicine that has been reported to improve fatigue, psychosomatic vulnerability, respiratory symptoms. We examined the efficacy NYT frailty or prefrailty COPD. Design: Prospective, single-center, open-label, randomized...
Use of systemic corticosteroids for the treatment coronavirus disease 2019 (COVID-19) among chronic obstructive pulmonary (COPD) patients is not well described. A 58-year-old man with fever and progressive dyspnea was admitted to Showa University Hospital, showed severe respiratory failure which needed mechanical ventilation. His chest computed tomography scanning emphysema bilateral ground-glass opacity caused by acute syndrome 2 (SARS-CoV-2) infection. He received 30 mg prednisolone five...
1. Viegi G, Scognamiglio A, Baldacci S, Pistelli F, Carrozzi L. Epidemiology of chronic obstructive pulmonary disease (COPD). Respiration. 2001;68:4-19. doi:10.1159/000050456. CrossRef Google Scholar
Patients with chronic obstructive pulmonary disease (COPD) are more inclined to have a high level of social vulnerability due their physical and psychological burden. However, date, there been no study on frailty in patients COPD. This aimed investigate the prevalence, characteristics, impact COPD.Social was assessed using five items questionnaire. A patient diagnosed if responses two or were positive. Four hundred COPD for frailty, dyspnea, appetite. We also prospectively examined number...
Viral infection is the main cause of asthma and COPD (chronic obstructive pulmonary disease) exacerbation accumulate inflammatory cells to airway tissue. We have reported poly I:C, a mimic product virus ligand toll-like receptor 3 (TLR3), induced chemokines from epithelial found prior incubation with corticosteroids diminishes effect TLR3 activation. In clinical practice, mild recommended as-needed budesonide (BUD) when symptoms occur following viral infection, etc. However, many questions...
Chronic obstructive pulmonary disease (COPD) and asthma have similar clinical features are both exacerbated by airway infection.To determine whether garenoxacin mesylate hydrate (GRNX) added to the standard care for bacterial infection-induced acute exacerbation of or COPD in adults has benefits.This single-arm trial was conducted from January 2015 March 2016. Adults with a history more than 12 months were recruited within 48 h presentation fever deterioration requiring additional...
Introduction: Inhalation of fungal allergens induces airway epithelial damage following inflammation and excessive mucus secretion, which can lead to severe asthma with sensitization (SAFS). Comprehensive gene expression analysis in Alternaria-exposed mouse airways, a model SAFS, has not been conducted. Methods: BALB/c mice received intranasal administration Alternaria extract or phosphate-buffered saline twice week for 6 weeks. Lung sections bronchoalveolar lavage fluid were obtained assess...
Background and objectives: Incidence rates of pulmonary nontuberculous mycobacterial (NTM) disease have been increasing, especially in the elderly population. Given limited evidence regarding safety efficacy NTM treatment, this study aimed to evaluate same among patients. Material methods: Patients diagnosed with at a tertiary hospital from January 2007 December 2017 were enrolled data then retrospectively collected. Data patients who received antimycobacterial treatment analyzed. Results: A...
Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a severe condition with limited treatment strategies. Although respiratory infection major cause AE-IPF, no reports have indicated pertussis as cause. Here we report two cases infection-induced AE-IPF. Both patients presented chief complaint acute distress and were previously diagnosed (IPF). Neither patient had received any vaccination since adolescence. AE-IPF accompanying based on chest computed tomography serum toxin...
<b><i>Introduction:</i></b> Bronchoconstriction was recently shown to cause airway remodeling and induce allergic inflammation in asthma. However, the mechanisms how mechanical stress via bronchoconstriction could remain unclear. <b><i>Objective:</i></b> We investigated effect of induced by methacholine inhalation a murine model <b><i>Methods:</i></b> BALB/c female mice were sensitized challenged with ovalbumin (OVA),...
The efficacy and safety of dupilumab, a humanized interleukin (IL)-4 receptor alfa monoclonal antibody (mAb) that inhibits the signaling type 2 cytokines IL-4 IL-13, for treatment uncontrolled eosinophilic asthma remains to be fully characterized, particularly in comparison other therapeutic mAbs. Therefore, we conducted meta-analysis randomized controlled trials (RCTs) indirectly compare dupilumab with those mepolizumab, anti-IL-5 mAb, patients asthma. Comparisons were made using Bayesian...
Chlorella extract （CE） has been shown to induce production of T helper-1 cytokines, and regulate serum IgE levels in animal models asthma. We aimed evaluate whether CE could inhibit ovalbumin （OVA）-induced airway hyperresponsiveness （AHR） remodeling a murine model Balb/c mice were allocated four groups: control group （no OVA exposure, not given CE）, an asthma （sensitized/challenged with OVA, CE） CE＋asthma CE）. In the groups, sensitized on day 0 12, then challenged three consecutive days....