A5057193010- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Enzyme function and inhibition
- Bioactive Compounds and Antitumor Agents
- Computational Drug Discovery Methods
- Phenothiazines and Benzothiazines Synthesis and Activities
- Metal complexes synthesis and properties
- Click Chemistry and Applications
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Essential Oils and Antimicrobial Activity
- HIV/AIDS drug development and treatment
- Crystal structures of chemical compounds
- Nanocomposite Films for Food Packaging
- Nonlinear Optical Materials Research
- Histone Deacetylase Inhibitors Research
- Crystallization and Solubility Studies
- Free Radicals and Antioxidants
- Chemical Synthesis and Analysis
- Biochemical and Molecular Research
- Chemical Reaction Mechanisms
- Microwave-Assisted Synthesis and Applications
- Synthesis of Tetrazole Derivatives
- Chemical synthesis and alkaloids
- Tuberculosis Research and Epidemiology
University of Nigeria
2014-2024
University of Mauritius
2022
University of Auckland
2022
Abstract Seven chalcone derivatives were synthesized by the Claisen-Schmidt condensation. The structures of compounds confirmed spectral data (Ultraviolet/visible, infrared, nuclear magnetic resonance and mass spectroscopy). tested for their in silico vitro antimicrobial antioxidant activities. molecular docking assessments showed that all exhibited good binding affinity with target microorganism proteins but, 6e 6g better compared standards. test revealed screened active against S...
Bacterial resistance to antibiotics over the past few decades has become one of most challenging problems infectious treatment. Sulphonamides and carboxamides have shown quite a number pharmacological properties against different types diseases among which is microbial infection. Ten new derivatives benzenesulphonamide bearing carboxamide functionality were synthesized investigated for their in vivo anti-inflammatory, vitro anti-microbial anti-oxidant activities. The base promoted reactions...
Experimental and theoretical investigation of the anti-hypertensive activity novel 2-[N-(4-methylbenzenesulfonyl)-1-phenylformamido]-N-(4-nitrophenyl)-3-phenylpropenamide (MBPNPP) was carried out. The experimental approach followed dietary induction spontaneously hypertensive adult male Wistar rats (SHRs) using 66% w/v D-fructose angiotensin I-converting enzyme (ACE) inhibitory assay while study achieved DFT calculations molecular docking against hypertension responsive proteins....
The study aimed to investigate novel pyrrolidine-pentanamide derivatives of sulfonamides as potential anti-malaria agents through a comprehensive approach involving experimental, theoretical, and in silico evaluations. compounds were synthesized using standard methods characterized NMR, FT-IR, HRMS techniques. molecular properties the investigated density functional theory (DFT) at B3LYP-D3 meta-functional/GenECP theoretical level. calculated vibrational frequencies showed good agreement...
A tripodal Schiff base ligand, 2,4,6-Tris(4-carboxybenzimino)-1,3,5-triazine (MT) and its trinuclear Dy(III), Er(III), Gd(III) complexes were synthesized. These characterized using UV-visible, IR, 1H, 13C NMR spectroscopies, elemental analysis, molar conductivity measurements. The spectral studies indicate that the ligand is hexadentate coordinates to Ln(III) ions through oxygen atoms of carboxylic group. as being bridged by carboxylate anions salen centers displaying a coordination number...
Abstract Carboxamide derivatives containing p‐ toluenesulfonamide functionality were synthesized by the environmentally friendly method using zinc chloride catalyst. All compounds; 2‐ N ‐(4‐methylbenzenesulfonyl)‐1‐phenylformamido‐ ‐(4‐nitrophenyl) acetamide (MBPNA), ‐(4‐nitrophenyl)‐3‐phenyl propanamide (MBPNPP), 3‐(1 H ‐indol‐2‐yl)‐2‐ (HIMBPNP) and 4‐Methyl‐2‐ pentanamide (MBPNP) characterized FT‐IR, 1 13 C NMR studies. Density functional theory (DFT) investigations B3LYP/6‐311++G (d, p)...
Sulphonamides and carboxamides have great pharmacological importance. The purpose of the study was to synthesize alanine-derived bioactive sulphonamides bearing evaluate their biological activities. reaction p-toluenesulphonyl chloride with L-alanine afforded compound 1, which acetylated obtain 2. chlorination ammonolysis 2 gave carboxamide backbone (3) coupled aryl/heteroaryl halides afford hybrid compounds 4, 5 6. Structures were confirmed by FTIR, 1H-NMR, 13C-NMR spectra elemental...
Synthesis of sulfonamide through an indirect method that avoids contamination the product with no need for purification has been carried out using process. Here, we report synthesis a novel compound, ({4-nitrophenyl}sulfonyl)tryptophan (DNSPA) from 4-nitrobenzenesulphonylchloride and L-tryptophan precursors. The slow evaporation was used to form single crystals named compound methanolic solution. characterized by X-ray crystallographic analysis spectroscopic methods (NMR, IR, mass...
Synthesis of angular polycyclic phenoxazine derivatives incorporating different phenols is reported in 30-99% yields. O-arylation 6-chlorodibenzo[a,j] phenoxazin-5-one with a variety electron-deficient, electron-neutral and electron-rich under the catalytic palladium (II) acetate/t-BuXphos system furnished compounds interest. The highest yields were obtained when intermediate was coupled phenols. IR, 1H-NMR, 13C-NMR Mass spectra data, confirmed structures all synthesized compounds. Study on...
Abstract Review: 120 refs.
Oxidative stress occurs when oxygen radical formation and levels exceed those of antioxidants, potentiating cell responses such as apoptosis, tumorigenesis, immune response. In an event of microbial invasion, there is a production Reactive-Oxygen-Species (ROS), which in excess can lead to oxidative stress. Some these microorganisms are opportunistic pathogens implicated chronic inflammatory conditions including cystic fibrosis. The synthesis, anti-inflammatory, antimicrobial antioxidant...
Abstract Review: 146 refs.
In this manuscript, the authors explore antimicrobial and anti-inflammatory properties of extracts from two commonly found used leaves species Murraya koenigii Ocimum gratissimum L ., Ethanolic were obtained by maceration then concentrated. Serial dilutions done for testing. The tested growth inhibition four bacterial fungal strains. Visual examination inhibition, compared to standard antibiotic controls, provided minimum inhibitory concentrations against six microbial another experiment,...
In this manuscript, the authors explore antimicrobial and anti-inflammatory properties of extracts from two commonly found used leaves species Murraya koenigii Ocimum gratissimum L ., Ethanolic were obtained by maceration then concentrated. Serial dilutions done for testing. The tested growth inhibition four bacterial fungal strains. Visual examination inhibition, compared to standard antibiotic controls, provided minimum inhibitory concentrations against six microbial another experiment,...