Background: There is evidence for an association between major depressive disorder (MDD) and both inflammatory phosphodiesterase (PDE) pathways. This study aimed to evaluate the adjunct role of PDE inhibitor pentoxifylline (PTX), a compound with anti-inflammatory properties, in treatment adult patients MDD. Methods: was prospective, 12-week, double-blind parallel groups. Eighty outpatients who met DSM-IV criteria MDD participated trial. Patients were required have baseline Hamilton Rating...

Profound and prolonged neutropenia following chemotherapy is a major risk factor for systemic fungal infection. As the early diagnosis of invasive infection (IFI) difficult, these infections are still associated with high morbidity mortality. Recently, Pan-fungal polymerase chain reaction (PCR) has been promising aid in rapid, IFI. During past few years, increasing numbers suspected IFIs were encountered at our institution patients after intensified immunosuppressive chemotherapy. The aim...

The Review of Diabetic Studies,2013,10,1,58-67.DOI:10.1900/RDS.2013.10.58Published:May 2013Type:Original ArticleAuthors:Sahar K. Hegazy, Osama A. Tolba, Tarek M. Mostafa, Manal Eid, and Dalia R. El-Afify Author(s) affiliations:Sahar Hegazy1, Tolba2, Mostafa1, Eid3, El-Afify1 1Department Clinical Pharmacy, Faculty Tanta University, EGYPT. 2Department Pediatrics, Medicine, EGYPT . 3Department Pathology, Abstract:Background: Oxidative stress plays an important role in the development diabetic...

Abstract Background and objective Paclitaxel doxorubicin are associated with neurotoxicity cardiotoxicity respectively. This study aimed at investigating the role of alpha-lipoic acid (ALA) in counteracting paclitaxel-induced neuropathy doxorubicin-associated women breast cancer. Patients methods randomized double-blind placebo-controlled prospective included 64 patients cancer who were into control group ( n = 32) which received 4 cycles plus cyclophosphamide (every 21 days) followed by...

This study aimed to evaluate the efficacy and immunomodulatory effect of rifaximin as another promising prophylactic therapy against spontaneous bacterial peritonitis (SBP) in cirrhotics.Seventy cirrhotic patients with ascites were included study. Patients divided into two groups a randomized single-blind fashion. Group one (n=40) received group (n=30) norfloxacin (control group). The treatment duration was 6 months. Serum levels tumor necrosis factor alpha (TNF-α), interleukin-6 ( IL-6),...

The purpose of this study was to determine the effect lamotrigine (LTG) and levetiracetam (LEV) as mono- polytherapy on biochemical markers bone turnover mineral density in Egyptian adult patients with epilepsy.Forty-eight were divided into four groups: two received monotherapy either LTG or LEV, other groups comprising (valproate [VPA] + VPA LEV). Thirty matched healthy participants included study. Participants completed a nutritional physical activity questionnaire. Biochemical metabolism...

Hepatic encephalopathy (HE) is a neuropsychiatric complication of liver cirrhosis. HE associated with poor survival and detrimental effects on quality life (QOL). The drawbacks the long-term use rifaximin in necessitates searching for alternative therapies. In this context, our study aimed at evaluating safety efficacy nitazoxanide (NTZ) as compared to (RFX) preventing recurrence assessing its impact QOL.This prospective, randomized, double-blind controlled included 60 patients who were...

Anemia associated with chronic kidney disease is a serious complication necessitating expenditure of huge medical efforts and resources. This study investigates the role alpha-lipoic acid (ALA) in end stage renal patients undergoing hemodialysis. By virtue its antioxidative effects, ALA expected to act as an erythropoietin (EPO) adjuvant, also has extended beneficial effects on endothelial dysfunction.Forty-four hemodialysis receiving EPO were randomized into two groups: first group received...

The results of a laboratory investigation on local scour at bridge abutments in cohesive soils are presented. Kaolin clay was used as bed material and vertical wall with three different sizes. Forty experiments were conducted under clear-water conditions soil content ranging from 2 to 20%, compaction ranges 57 88%, liquidity index 0.03 0.99 the approach flow Froude numbers 0.3 0.55. Equations developed predict equilibrium pattern around abutment, including maximum depth, volume, width,...

<h3>Objectives:</h3> To investigate the anti-tumor activity and tolerability of celecoxib as an adjuvant therapy for patients with metastatic colorectal cancer (CRC). <h3>Methods:</h3> In this randomized controlled study, 54 CRC were into 2 groups; control group (n=28) which received 6 cycles folinic acid, fluorouracil irinotecan (FOLFIRI) regimen (5-flourouracil, leucovorin, irinotecan), (n=26) FOLFIRI plus 200&nbsp;mg twice daily. The study duration was 3 months. Patients assessed at...

Metformin may provide a therapeutic benefit in different types of malignancy.We aimed at evaluating the effect metformin as an adjuvant therapy to letrozole on estradiol and other biomarkers involved pathogenesis breast cancer overweight obese postmenopausal women.Seventy-five stages II-III female patients were assessed for eligibility open-labeled parallel pilot study. Forty-five met inclusion criteria assigned into three arms: lean arm (n = 15) women who received 2.5 mg/day, control...

: Rheumatoid artherits (RA) is a refractory disease and the imbalance between pro- anti-inflammatory cytokines in favor of pro-inflammatory has been implicated pathogenesis RA. In this context, aim present study was to compare antioxidant effects candesartan, an angiotensin-receptor blocker, atorvastatin RA patients.: single-blinded parallel randomized placebo controlled study, patients recruited December 2017 May 2018 were categorized into three groups: group 1 included 15 who served as...

Objective: There are discrepancies about the relationship of IL-6, clusterin and irisin with obesity associated insulin resistance also their sexual dimorphism. This study aimed at evaluating circulating levels in obese subjects both sexes who had different grades examining dimorphism association resistance. Subjects methods: included 176 non-diabetic were classified according to sex into two groups; male female groups. The group (88 men) was BMI into; 1 (22 lean men), 2 class I 3 II 4 III...