A5101583774- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- PI3K/AKT/mTOR signaling in cancer
- Helminth infection and control
- Radiopharmaceutical Chemistry and Applications
- Metabolism, Diabetes, and Cancer
- Cancer Risks and Factors
- Gene expression and cancer classification
- Estrogen and related hormone effects
- Silkworms and Sericulture Research
- Lung Cancer Treatments and Mutations
- Molecular Biology Techniques and Applications
- Cancer Research and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Photoacoustic and Ultrasonic Imaging
- Medical and Biological Sciences
- Brain Metastases and Treatment
- BRCA gene mutations in cancer
- Yersinia bacterium, plague, ectoparasites research
- Forensic Entomology and Diptera Studies
- Lung Cancer Research Studies
- Circadian rhythm and melatonin
Ministry of Health of the Russian Federation
2021-2023
Moscow State University
1973
Lomonosov Moscow State University
1973
The GC content and amount of 5-methylcytosine (5-MeCyt) have been determined in total DNA from certain organs male albino rats 1, 12 28 months age. A marked tissue specificity with respect to the 5-MeCyt has revealed. decreases age brain, heart spleen; it does not change liver lungs slightly increases kidneys. There are no other differences studied (GC content, T<sub>m</sub> physico-chemical properties). Thus, most probably due different level methylation. changes drastically...
Цель. оценка эффективности суперселективной химиоэмболизации сосудов опухоли в комбинации с химиотерапией и лучевой терапией у пациентов местно-распространенными злокачественными опухолями носоглотки. Материал методы. Проведено ретроспективное исследование проспективным наблюдением разделением на две группы: группе ХЭ+ХЛТ - первым этапом выполнялась суперселективная химиоэмболизация последующей сочетанной химиолучевой (ХЛТ), адъювантной (АХТ), ХЛТ АХТ. Оценка проводилась по бессобытийной...
Nowadays great successes have been reached in chemotherapy treatment of cancer. New medications let increase time to progression, overall survival and improve a quality life. Recently, antitumor activity melatonin is actively investigated. Many vitro/in vivo studies are devoted this topic. In these trials was shown ability inhibit tumor growth potentiate the cytotoxic effects chemotherapy. This review describes use patients with solid tumors. Melatonin has used both monotherapy combination...
Complete clinical response (determined by palpation, instrumental methods, and macroscopic examination) does not always imply the achievement of pathologic complete response. Correlation coefficient between responses is 0.6–0.7. Objective: to choose an optimal method for assessment residual tumor that will provide objective information on efficacy various neoadjuvant systemic therapy (NST) regimens. Materials methods. We investigated trepanobiopsy samples breast tumors collected prior NST...
Background. Breast cancer is one of the most common female malignancies. Molecular diagnostic methods tumor profiling allow us to analyze individual characteristics, identify new prognostic and predictive markers. Aim. To increase efficacy systemic therapy for breast reduce inappropriate prescriptions using data on molecular characteristics; develop a polygenic panel ensure tailored approach cancer. Materials methods. We analyzed 84 tissue samples from pre- postmenopausal women with...
More than 70 % of patients with breast cancer have estrogen-receptor-positive tumors (ER+) and are considered hormone- sensitive. That is why a vast majority early operable receive adjuvant endocrine therapy. Patients metastatic ER+ also hormone therapy as first-line treatment. ER+/PR+ locally advanced including potentially cases (cT2N1, cT3N0M0) still subject to neoadjuvant chemotherapy in most the oncology centers Russia worldwide. 10 years ago, several trials evaluating efficacy were...
69 female FVB/N mice were used. After subcutaneous inoculation of tumor cells transplantable HER2-positive mammary adenocarcinoma all animals randomly divided into 7 groups and received metformin 100 mg /kgdaily, melatonin 10 mg/kg daily, paclitaxel 6 once a week as monotherapy or in combination. Treatment efficacy was assessed by growth inhibition the index. It shown that increased cytotoxic effect pacli-taxel whereas with led to statistically significant
The article discusses modern approaches in the treatment of HER2-positive breast cancer (BC) with brain metastases (BM).The patients are subject to multidisciplinary, comprehensive and biologically – oriented treatment, involvement a neurosurgeon radiation therapist make decision considering local BM, as well clinical oncologist choose systemic drug therapy. Local HER2+ BC BM includes surgical and/or radiotherapy. Use targeted anti-HER2 therapy changes “biology” disease from aggressive...
Clinical trials of metformin efficacy in breast cancer were reviewed this article. According to some data from cohort and case-controlled studies, the use with combined therapy improves overall disease-free survival. Initial randomized clinical adjuvant neoadjuvant are expected nearest future.
Aim. To increase the efficacy of systemic breast cancer therapy and reduce inappropriate prescriptions using individual immunohistochemical tumor characteristics, as well to develop prognostic scales ensure a tailored approach adjuvant treatment in patients. Materials methods. We conducted comprehensive study that included collection literature data on clinical, pathomorphological, prognostic, predictive factors cancer, retrospective cohort from registry. also performed histological...
Materials and methods. The effect of melatonin (MLT) metformin (MTF) on the efficacy neoadjuvant hormone therapy with toremifene was investigated in 54 patients estrogen receptor-positive, locally advanced breast cancer (ER + BC). average age women 67 years. had no diabetes mellitus. first group (n = 19) received 120 mg per day, second 16) - combination MLT 3 orally every night, third MTF 850 twice daily. Randomization performed 1: 1. duration all study groups 4 months. After end treatment,...
Purpose: To create a unified system of accelerated clinical trials new drugs and regimens for breast cancer (BC). Materials methods: The study included 1214 patients with BC different stages (cT1N1, cT2N1-2, cT2-3N0-2, cT2-3N0-1, cT4N0M0). According to trepan biopsy data immunohistochemical examination (IHC) expression ER, PR, HER2, Ki67 was determined. TUBBßIII, TOP2a, analyzes on the BRCA1/2 mutation studied. response neoadjuvant treatment determined using physical method,...
The purpose of this study was to evaluate the capabilities sonoelastography monitor neoadjuvant chemotherapy breast cancer and determine correlation between reduction stiffness tumor grade pathology response.
Background. Individual molecular characteristics of a tumor can serve as basis for tailored approach to therapy, prediction the disease course and outcome, timely treatment correction in cancer patients. Tumor genomic profiling allows more precise assessment an individual manner. Accurate identification HER2 status breast is crucial clinical decisions appropriate strategy. Aim. To increase efficacy systemic therapy cancer, reduce inappropriate prescribing, ensure using information on tumor....
Background . Individual molecular characteristics of a tumor can serve as basis for tailored approach to therapy, prediction the disease course and outcome, timely treatment correction in cancer patients. Tumor genomic profiling allows more precise assessment an individual manner. Accurate identification HER2 status breast is crucial clinical decisions appropriate strategy. Aim. To increase efficacy systemic therapy cancer, reduce inappropriate prescribing, ensure using information on tumor....