A5036032945- Polymer Surface Interaction Studies
- Electrospun Nanofibers in Biomedical Applications
- Advanced Sensor and Energy Harvesting Materials
- Surface Modification and Superhydrophobicity
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Engineering Education and Pedagogy
- Biomedical and Engineering Education
- Experimental Learning in Engineering
- Silk-based biomaterials and applications
- Antifungal resistance and susceptibility
- Bone Tissue Engineering Materials
- Magnetic Properties and Applications
- Nanoplatforms for cancer theranostics
- Analytical Chemistry and Sensors
- Nanocluster Synthesis and Applications
- Antimicrobial agents and applications
- Bacteriophages and microbial interactions
- Dielectric materials and actuators
- Advanced Nanomaterials in Catalysis
- Manufacturing Process and Optimization
- Magnetic Properties and Synthesis of Ferrites
- Blood transfusion and management
- Acute Kidney Injury Research
- 3D Printing in Biomedical Research
University of Georgia
2019-2025
University of Strathclyde
1999
Hybrid organic-inorganic materials are attracting enormous interest in science due to the combination of multiple advantageous properties both organic and inorganic components. Taking advantage a simple, scalable, solvent-free hard-sacrificial method, we report successful fabrication three-dimensional hybrid porous foams by integrating two types fillers into poly(dimethylsiloxane) (PDMS) framework. These consist hydrophobic electrically conductive graphene (GR) nanoplatelets bactericidal...
The treatment of critically ill patients has made great strides in the past few decades due to rapid development indwelling medical devices. Despite immense advancements design these devices, device-associated infections and thrombosis are two major clinical problems that may lead device failure compromise outcomes. Antibiotics current choice for infections; however, global emergence antibiotic-resistance their biofilm formation abilities complicate management such infections. Moreover,...
Biofilm and thrombus formation on surfaces results in significant morbidity mortality worldwide, which highlights the importance of development efficacious fouling-prevention approaches. In this work, novel highly robust superhydrophobic coatings with outstanding multiliquid repellency, bactericidal performance, extremely low bacterial blood adhesion are fabricated by a simple two-step dip-coating method. The prepared combining 1H,1H,2H,2H-perfluorooctyltriethoxysilane (FAS-17)-coated...
Devices used for extracorporeal circulation are met with two major medical concerns: thrombosis and infection. A device that allows anticoagulant-free while reducing the risk of infection has yet to be developed. We report use a copper nanoparticle (Cu NP) catalyst release nitric oxide (NO) from endogenous donor S-nitrosoglutathione (GSNO) in coating applied commercial Tygon S3 E-3603 poly(vinyl chloride) tubing order reduce adhered bacterial viability occurrence first time an animal model....
The management of thrombosis and bacterial infection is critical to ensure the functionality medical devices. While administration anticoagulants current antithrombotic clinical practice, a variety complications, such as uncontrolled hemorrhages or heparin-induced thrombocytopenia, can occur. Additionally, rates remain costly deadly complication associated with use these It has been hypothesized that if synthetic surface could mimic biochemical mechanisms endothelium blood vessels, be...
In medical device design, there is a vital need for coating that promotes treatment of the patient and simultaneously prevents fouling by biomacromolecules which in turn can progress to infections, thrombosis other device-related complications.
In this study, the preparation and characterization of nitric oxide (NO) releasing silk fibroin nanoparticles (SF NPs) are described for first time. S-Nitroso-N-acetylpenicillamine (SNAP)-loaded SF NPs (SNAP-SF were prepared via an antisolvent/self-assembling method by adding a SNAP/ethanol solution to aqueous freeze-thawing. The SNAP-SF had diameter ranging from 300 400 nm overall negative charge −28.76 ± 0.73 mV. Among different SNAP/SF ratios tested, highest encapsulation efficiency (18.3...
Indwelling medical devices currently used to diagnose, monitor, and treat patients invariably suffer from two common clinical complications: broad-spectrum infections device-induced thrombosis. Currently, are managed through antibiotic or antifungal treatment, but the emergence of resistance, formation recalcitrant biofilms, difficulty identifying culprit pathogens have made treatment increasingly challenging. Additionally, systemic anticoagulation has been manage thrombosis, subsequent...
Abstract Silicone rubber (SR), a common medical‐grade polymer used in medical devices, has previously been modified for nitric oxide (NO) releasing capabilities. However, the effects of material properties such as film thickness on NO release kinetics are not well explored. In this study, SR is first analysis how polymer's affects storage and uptake an donor subsequent properties. Observed trends show that results tunable release. These indicate crucial to optimize efficient effective method.
Abstract Numerous biomaterials have been developed for application in blood‐contacting medical devices to prevent thrombosis; however, few materials applied full‐scale and evaluated hemocompatibility under clinical blood flow conditions. We a dual‐action slippery liquid‐infused (LI) nitric oxide (NO)‐releasing material modification (LINO) circulation tubing extracorporeal lung support the ex vivo using swine whole circulated 6 h at clinically relevant flow. LINO was compared unmodified...
Abstract Laboratory sections are at the core of undergraduate STEM education as they grant students ability to observe how physical world compares concepts taught in classroom. In context engineering (as an applied science field), focus on application educational setting is especially crucial towards proper career development; however, biological (BE) community faces a multitude barriers implementing hands-on lab sections. The main challenge for BE educators that relatively new and broad...
Background: Numerous biomaterials are developed to mitigate untoward effects of blood exposure foreign surfaces on blood-contacting medical devices, such as extracorporeal life support (ECLS); however, limited testing is performed using clinical flow conditions and device components. A liquid infused nitric oxide-releasing (LiNORel) material was prevent surface protein adsorption while eluting oxide (NO) minimize platelet activation aggregation. The study objective assess LiNORel applied...