A5015345971- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Skin and Cellular Biology Research
- Histone Deacetylase Inhibitors Research
- Nuclear Receptors and Signaling
- Developmental Biology and Gene Regulation
- Pluripotent Stem Cells Research
- Genomics and Chromatin Dynamics
- Cancer-related gene regulation
- Genetics, Aging, and Longevity in Model Organisms
- Wnt/β-catenin signaling in development and cancer
- Skin Protection and Aging
- Apelin-related biomedical research
- Hair Growth and Disorders
- Hedgehog Signaling Pathway Studies
- MicroRNA in disease regulation
- RNA Research and Splicing
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Reproductive Biology and Fertility
- Ocular Disorders and Treatments
LakePharma (United States)
2018
Stanford University
2004-2011
Howard Hughes Medical Institute
2010
A Lot of HOTAIR The roles several classes small (<50 nucleotides) noncoding RNAs are beginning to be defined in molecular detail, whereas the function most long (∼200+ nucleotides), intergenic (linc)RNAs found eukaryotic genomes remains something a mystery. lincRNA, which is transcribed from mouse HOXC locus, binds Polycomb Repressive Complex 2 (PRC2) and recruits it HOXD other genes, where its histone methylase activity acts repress gene transcription. Tsai et al. (p. 689 , published...
Reduced bone morphogenetic protein receptor 2 (BMPR2) expression in patients with pulmonary arterial hypertension (PAH) can impair EC (PAEC) function. This adversely affect survival and promote SMC proliferation. We hypothesized that interventions to normalize of genes are targets BMPR2 signaling could restore PAEC function prevent or reverse PAH. Here we have characterized, human PAECs, a BMPR2-mediated transcriptional complex between PPARγ β-catenin shown disruption this impaired...
Reciprocal epithelial–mesenchymal interactions shape site-specific development of skin. Here we show that HOX expression in fibroblasts is cell-autonomous and epigenetically maintained. The distal-specific gene HOXA13 continually required to maintain the transcriptional program adult fibroblasts, including WNT5A, a morphogen for distal development. ability induce epidermal keratin 9, gene, abrogated by depletion HOXA13, but rescued addition WNT5A. Thus, maintenance appropriate may serve as...
Trimethylation of histone H3 on Lys 27 (H3K27me3) is key for cell fate regulation. The H3K27me3 demethylase UTX functions in development and tumor suppression with undefined mechanisms. Here, genome-wide chromatin occupancy analysis associated modifications reveals distinct classes target genes, including genes encoding Retinoblastoma (RB)-binding proteins. removes maintains expression several RB-binding proteins, enabling cycle arrest. Genetic interactions mammalian cells Caenorhabditis...
Sonic hedgehog (Shh) signaling plays a critical role during development and carcinogenesis. While Gli family members govern the transcriptional output of Shh signaling, little is known how Gli-mediated activity regulated. Here we identify actin-binding protein Missing in Metastasis ( MIM ) as new Shh-responsive gene. Together, Gli1 recapitulate Shh-mediated epidermal proliferation invasion regenerated human skin. part Gli/Suppressor Fused complex potentiates Gli-dependent transcription using...
Abstract Royal jelly is the queen-maker for honey bee Apis mellifera , and has cross-species effects on longevity, fertility, regeneration in mammals. Despite this knowledge, how royal or its components exert their myriad remained poorly understood. Using mouse embryonic stem cells as a platform, here we report that through major protein component Royalactin, can maintain pluripotency by activating ground-state pluripotency-like gene network. We further identify Regina, mammalian structural...