A5084303957- Multiple Sclerosis Research Studies
- Neural dynamics and brain function
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Ultrasound Imaging and Elastography
- Long-Term Effects of COVID-19
- EEG and Brain-Computer Interfaces
- Orthopedic Surgery and Rehabilitation
- Scoliosis diagnosis and treatment
- Musculoskeletal pain and rehabilitation
- Neural and Behavioral Psychology Studies
- Hearing Loss and Rehabilitation
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
Vrije Universiteit Brussel
2020-2025
Universitair Ziekenhuis Brussel
2025
Abstract Background and purpose Data from neuro‐imaging techniques allow us to estimate a brain's age. Brain age is easily interpretable as ‘how old the brain looks’ could therefore be an attractive communication tool for health in clinical practice. This study aimed investigate its utility by investigating relationship between cognitive performance multiple sclerosis (MS). Methods A linear regression model was trained predict magnetic resonance imaging volumetric features sex healthy...
Multi-item working memory (WM) is a complex cognitive function thought to arise from specific frequency band oscillations and their interactions. While some theories consistent findings have been established, there still lot of unclarity about the sources, temporal dynamics, roles event-related fields (ERFs) theta, alpha, beta during WM activity. In this study, we performed an extensive whole-brain ERF time-frequency analysis on n-back magnetoencephalography data 38 healthy controls. We...
Background Cognitive deterioration is common in multiple sclerosis (MS) and requires regular follow-up. Currently, cognitive status measured clinical practice using paper-and-pencil tests, which are both time-consuming costly. Remote monitoring of could offer a solution because previous studies on telemedicine tools have proved its feasibility acceptance among people with MS. However, existing smartphone-based apps include designs that prone to motor interference focus primarily information...
Abstract Background and purpose Cognitive impairment in multiple sclerosis (MS) is common associated with problems employment, driving ability, quality of life. Since cognitive at time diagnosis predictive disability progression, early assessment annual monitoring recommended. The Brief International Assessment Multiple Sclerosis (BICAMS) was introduced as a time‐efficient screening tool that can easily be applied standard clinical care. However, besides application, tests need to analysed...
Working memory (WM) problems are frequently present in people with multiple sclerosis (MS). Even though hippocampal damage has been repeatedly shown to play an important role, the underlying neurophysiological mechanisms remain unclear. This study aimed investigate underpinnings of WM impairment MS using magnetoencephalography (MEG) data from a visual-verbal 2-back task. We analysed MEG recordings 79 patients and 38 healthy subjects through event-related fields theta (4-8 Hz) alpha (8-13...
Abstract Graph-theoretical analysis is a novel tool to understand the organisation of brain. We assessed whether altered graph theoretical parameters, as observed in multiple sclerosis (MS), reflect pathology-induced restructuring brain's functioning or result from reduced signal quality functional MRI (fMRI). In cohort 49 people with MS and matched group 25 healthy subjects (HS), we performed cognitive evaluation acquired fMRI. From fMRI measurement, Pearson correlation-based networks were...
The Nine-Hole Peg Test (9HPT) is the golden standard to measure manual dexterity in people with multiple sclerosis (MS). However, administration requires trained personnel and dedicated time during a clinical visit.
Abstract Advanced structural brain imaging techniques, such as diffusion tensor (DTI), have been used to study the relationship between DTI-parameters and cognitive scores in multiple sclerosis (MS). In this study, we assessed function 61 individuals with MS a control group of 35 healthy Symbol Digit Modalities Test, California Verbal Learning Test-II, Brief Visuospatial Memory Test-Revised, Controlled Oral Word Association Stroop-test. We also acquired diffusion-weighted images (b = 1000;...
Background Data from neuro-imaging techniques allow us to estimate a brain’s age. Brain age is easily interpretable as “how old the brain looks”, and could therefore be an attractive communication tool for health in clinical practice. This study aimed investigate its utility. Objectives To relationship between information processing speed MS. Methods A ridge-regression model was trained predict MRI volumetric features sex healthy control dataset (HC_train, n=1690). used two test sets:...
Abstract Background The Nine-Hole Peg Test (9HPT) is the golden standard in clinical practice to measure manual dexterity people with multiple sclerosis (MS). However, administration requires trained personnel and dedicated time during a visit. Objective To validate smartphone-based test for remote assessment, icompanion Finger Dexterity (FDT), be included into application. Methods 65 MS 81 healthy subjects performed first testing session, 21 second session approximately two weeks later....
Abstract Background Telemedicine is feasible and well-accepted by people with multiple sclerosis (MS). Objective The aim of this study to validate a smartphone-based cognitive screening battery, ico gnition , faster signal deterioration. Methods consists three tests (Symbol Test, Dot Test visual Backwards Digit Span (vBDS)) that are equivalents validated paper-pencil tests. These the Symbol Modalities (SDMT), 10/36 Spatial Recall (SPART) auditory (aBDS), respectively. To establish validity...
<sec> <title>BACKGROUND</title> Cognitive deterioration is common in multiple sclerosis (MS) and requires regular follow-up. Currently, cognitive status measured clinical practice using paper-and-pencil tests, which are both time-consuming costly. Remote monitoring of could offer a solution because previous studies on telemedicine tools have proved its feasibility acceptance among people with MS. However, existing smartphone-based apps include designs that prone to motor interference focus...
Abstract Working memory (WM) problems are frequent in persons with multiple sclerosis (MS). Even though hippocampal damage has been repeatedly shown to play an important role, the underlying neurophysiological mechanisms remain unclear. This study aimed investigate underpinnings of WM impairment MS using magnetoencephalography (MEG) data from a verbal n-back task. We analysed MEG recordings 79 patients and 38 healthy subjects through event-related fields (ERFs) theta (4-8 Hz) alpha (8-13...