A5061651308- Microbial metabolism and enzyme function
- Schizophrenia research and treatment
- Antibiotic Resistance in Bacteria
- Tuberous Sclerosis Complex Research
- Evolution and Genetic Dynamics
- Renal cell carcinoma treatment
- Renal and related cancers
- Gut microbiota and health
- Tryptophan and brain disorders
- Phenothiazines and Benzothiazines Synthesis and Activities
University of Illinois Chicago
2021-2024
University of Illinois Urbana-Champaign
2021-2024
Atypical antipsychotic (AAP) medication is a critical tool for treating symptoms of psychiatric disorders. While AAPs primarily target dopamine (D2) and serotonin (5HT2A 5HT1A) receptors, they also exhibit intrinsic antimicrobial activity as an off-target effect. Because are often prescribed to patients many years, potential risk associated with long-term AAP use the unintended emergence bacteria resistance (AMR). Here, we show that exposure quetiapine at estimated gut concentrations...
High-grade serous ovarian cancer (HGSOC) is the most lethal gynecological malignancy that primarily detected at metastatic stage. Most HGSOC originates from fallopian tube epithelium (FTE) and metastasizes to ovary before invading peritoneum; therefore, it crucial study disease initiation progression using FTE-derived models. We previously demonstrated loss of PTEN FTE leads cancer. In present study, in led enrichment stem cell markers such as LGR5, WNT4, ALDH1, CD44. Interestingly,...
High-grade serous ovarian cancer (HGSOC) accounts for 70-80% of all cancer-related deaths. Multiple studies have suggested that the fallopian tube epithelium (FTE) serves as cell origin HGSOC. Phosphatase and tensin homolog (PTEN) is a tumor suppressor its loss sufficient to induce numerous tumorigenic changes in FTE, including increased migration, formation multicellular spheroids (MTSs), colonization. In murine oviductal epithelial (MOE) cells (the equivalent human FTE) PTEN results...
ABSTRACT Atypical antipsychotic (AAP) medication is a critical tool for treating symptoms of psychiatric disorders. While AAPs primarily target dopamine (D2) and serotonin (5HT2A 5HT1A) receptors, they also exhibit intrinsic antimicrobial activity as an off-target effect. Because are often prescribed to patients many years, potential risk associated with long-term AAP use the unintended emergence bacteria resistance (AMR). Here, we show that exposure quetiapine at estimated gut...