A5047498736- Gout, Hyperuricemia, Uric Acid
- Crystallization and Solubility Studies
- Pharmacological Effects of Natural Compounds
- Textile materials and evaluations
- Magnetic Properties and Synthesis of Ferrites
- Garlic and Onion Studies
- Synthesis and bioactivity of alkaloids
- Mechanical Behavior of Composites
- X-ray Diffraction in Crystallography
- Microwave-Assisted Synthesis and Applications
- Musculoskeletal synovial abnormalities and treatments
- Urticaria and Related Conditions
- High-Velocity Impact and Material Behavior
- Autophagy in Disease and Therapy
- Adenosine and Purinergic Signaling
- Epigenetics and DNA Methylation
- Medicinal plant effects and applications
Icahn School of Medicine at Mount Sinai
2022
Morgan State University
2016-2019
A methodology is developed to visually analyze and quantify macroscale mesoscale impact damage on a single layer of S-2 glass/SC15 toughened epoxy plain weave composite. Specimens were clamped in 203 mm diameter circular frame impacted by 5.5 (0.22 caliber) right cylindrical steel projectile at velocities ranging from 104 472 m/s. High-resolution images obtained the point up edge using an 80 MP camera. Three types identified: (i) transverse tow cracks, (ii) tow–tow delamination, (iii) 45°...
Gout is a disease with elusive treatment options. Reduction of the size l-alanine crystals as model crystal for gouty tophi use monomode solid-state microwave was examined possible therapeutic aid. The effect heating on in presence gold nanoparticles (Au NPs) solution and synovial fluid (SF) plastic pouch through synthetic skin patch investigated. In this regard, three experimental paradigms were employed: Paradigm 1 includes variable power (5–10 W) time (5–60 s) Au NPs water (20 nm size,...
Gout is caused by the overproduction of uric acid and inefficient metabolism dietary purines in humans. Current treatments gout, which include anti-inflammatory drugs, cyclooxygenase-2 inhibitors, systemic glucocorticoids, have harmful side-effects. Our research laboratory has recently introduced an innovative approach for decrystallization biological chemical crystals using Metal-Assisted Microwave-Accelerated Evaporative Decrystallization (MAMAD) technique. In MAMAD technique, microwave...
Autophagy is a conserved metabolic pathway that central to many diseases. Recently, there has been lot of interest in targeting autophagy with small molecule inhibitors as possible therapeutic strategy. However, the compounds used for are nonselective. Here, we explored inhibition pancreatic cancer cells using established selective and discovered an unexpected link between progression through cell cycle. Our findings revealed treatments have different targets block replication activate other...
The use of indium tin oxide (ITO) and focused monomode microwave heating for the ultra-rapid crystallization L-alanine (a model amino acid) is reported.Commercially available ITO dots (< 5 mm) attached to blank poly(methyl)methacrylate (PMMA, cm in diameter with 21-well silicon isolators: referred as iCrystal plates) were found withstand prolonged during experiments.Crystallization was performed at room temperature control experiment), two sources: a 2.45 GHz conventional (900 W, power level...
Gout is a painful and prevalent crystal deposition disease caused by the overproduction of Uric Acid (UA) in body atypical human synovial joints as Monosodium Urate Monohydrate (MSUM). Conventional treatments, such NSAIDs, cyclooxygenase-2 inhibitors, systemic glucocorticoids often present harmful side-effects are short-lived.
In this paper, we tested a hypothesis that the metal-assisted and microwave-accelerated decrystallization (MAMAD) technique, based on combined use of low-power medical microwave heating (MWH) gold nanoparticles (Au NPs), can be used to decrystallize laboratory-prepared monosodium urate monohydrate crystal aggregate (pseudo-tophus) placed in three-dimensional (3D) synthetic human joint models. To simulate potential treatment chronic tophaceous gout using MAMAD three different 3D models...