A5054677442- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Chronic Lymphocytic Leukemia Research
- Genetic factors in colorectal cancer
- Cancer Research and Treatments
- Cancer Treatment and Pharmacology
- Multiple and Secondary Primary Cancers
- Liver Disease Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Breast Cancer Treatment Studies
- Occupational and environmental lung diseases
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- T-cell and Retrovirus Studies
- Lung Cancer Research Studies
- Renal and related cancers
- Hepatocellular Carcinoma Treatment and Prognosis
- Prostate Cancer Treatment and Research
- Metastasis and carcinoma case studies
- Pleural and Pulmonary Diseases
Cairo University
2012-2023
Cancer Institute (WIA)
2005-2016
CHU Dijon Bourgogne
2016
Centre Hospitalier Universitaire Henri-Mondor
2016
Children Cancer Hospital
1989-2013
Assiut University
2012
National Cancer Institute
2012
Georgetown University
2012
University of Maryland, Baltimore
2012
Beni-Suef University
2012
To compare patients with high-risk stage III to IV Hodgkin lymphoma (HL) in the phase European Organisation for Research and Treatment of Cancer 20012 Intergroup trial (Comparison Two Combination Chemotherapy Regimens Treating Patients With Stage or Hodgkin's Lymphoma) who were randomly assigned either doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD) etoposide, cyclophosphamide, vincristine, procarbazine, prednisone (BEACOPP).Patients clinical HL, International Prognostic Score 3...
Abstract Background: We investigated associations between tobacco exposure, history of schistosomiasis, and bladder cancer risk in Egypt. Methods: analyzed data from a case–control study (1,886 newly diagnosed histologically confirmed cases 2,716 age-, gender-, residence-matched, population-based controls). Using logistic regression, we estimated the covariate-adjusted ORs 95% confidence interval (CI) associations. Results: Among men, cigarette smoking was associated with an increased...
Locoregional failure for patients with locally advanced bladder cancer (LABC) after radical cystectomy (RC) is common even chemotherapy and associated high morbidity mortality. Adjuvant radiotherapy (RT) can decrease locoregional but has not been studied in the era.To investigate if adjuvant sequential RT plus improve recurrence-free survival (LRFS) compared alone.A randomized phase 3 trial was opened to compare vs RC LABC, a third arm added later as 2 alone, an emerging standard. The...
Background and objectiveDarolutamide is an androgen receptor inhibitor that increases overall survival in combination with deprivation therapy (ADT) patients metastatic hormone-sensitive nonmetastatic castration-resistant prostate cancer (PCa). This phase 2 study assessed the efficacy safety of darolutamide as monotherapy without ADT eugonadal testosterone levels.MethodsThis was a 24-wk, open-label, randomized hormone-sensitive, histologically confirmed PCa requiring gonadotropin-releasing...
Background: The gold standard for initial clinical diagnosis of bladder cancer involves cystoscopic examination and histological evaluation tissues. There is a critical need to identify non-invasive sensitive biomarkers. Early detection essential challenge in surveillance carcinoma. Exosomes are nano- sized vesicles present many biological fluids have significant role cancer. Thus, quantification exosomes different stages may be concern prognosis. Methods: Tumor derived levels urine serum...
8002 Background: Escalated BEACOPP and derivatives achieved superior time to treatment failure (FFTF) over COPP/ABVD, resulting in higher overall survival (OS) for advanced HL. However, later clinical trials have failed confirm OS superiority ABVD. Methods: Eligibility criteria: stage III/IV HL, International prognostic score (IPS) ≥ 3, age<60. We compared ABVD (8 cycles) vs. (escalated 4 cycles baseline 4), without irradiation. Randomization was stratified institution IPS. Primary...
Bladder cancer is one of the most common cancers worldwide. Gene expression profiling using microarray technologies improves understanding biology. The aim this study was to determine gene profile in Egyptian bladder patients.Samples from 29 human and adjacent non-neoplastic tissues were analyzed by cDNA microarray, with hierarchical clustering multidimensional analysis.Five hundred sixteen genes differentially expressed which SOS1, HDAC2, PLXNC1, GTSE1, ULK2, IRS2, ABCA12, TOP3A, HES1,...
ABSTRACT The authors examined the associations between farming and risk for squamous cell (SCC) or urothelial (UC) carcinoma of urinary bladder among Egyptians. used data from a multicenter case-control study (1,525 male 315 female cases, 2,069 547 age- residence-matched, population-based controls) to calculate adjusted odds ratios (AORs) 95% confidence intervals (CIs). Men in who never smoked had increased either SCC UC (AOR [95% CI]: 4.65 [2.59–8.36] 6.22 [3.82–10.15], respectively). If...
356 Background: There is growing interest in using adjuvant radiation therapy (RT) to reduce local failures (LF) after radical cystectomy (RC) for locally advanced bladder cancer. A previous RCT demonstrated significantly improved LF & OS with RT vs. RC alone. An was performed compare the efficacy of vs chemo-RT chemo alone RC. The primary endpoint disease-free survival (DFS). Secondary endpoints were OS, LRFS, DMFS and toxicity. Methods: Patients ≤ 70 yrs ECOG PS 2 cancer ≥ 1 high-risk...
Bladder cancer is the commonest type of malignant tumors as a result schistosomaisis which major healthy problem in many subtropical developing countries. The aim this study to comparatively elucidate underlying biochemical tumor markers schistosomal bladder versus non-schistosomal when compared normal ones. This work was performed on tissue specimens from total 25 patients and serum samples 30 ten individuals served control. investigated parameters are: xanthine oxidase (XO), fructosamine,...