A5047329136- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Cancer therapeutics and mechanisms
- Synthesis and pharmacology of benzodiazepine derivatives
- Sulfur-Based Synthesis Techniques
Chongqing University
2022-2023
The incorporation of the isoindole core into DNA-encoded chemical library is highly desirable for great potential pharmacological characters exampled by molecules like lenalidomide. Herein, we reported a DNA-compatible protocol OPA-mediated transformation amines drug-like moieties represented isoindolinone and thio-2-isoindole, respectively. high conversion wide substrate-scope property our render its feasibility in manipulation terminal on oligonucleotide conjugates, including...
Taking advantage of aryl diazonium intermediates, this work reported a DNA-compatible C–C bond formation strategy, achieving broad substrate scope, exquisite functional group tolerance, and orthogonality to halide-based coupling reactions.
The incorporation of N-containing heterocycles with potential bioactivity into DNA-encoded chemical libraries (DELs) represents an important approach to synthesizing medicinally useful compound collections for high-throughput screening. Herein, we reported a synthetic methodology afford benzotriazinone core as drug-like scaffold in DNA-compatible manner through aryl diazonium intermediates. Starting from DNA-conjugated amines, anthranilic acid or isatoic anhydride building blocks were...
DNA-compatible combinatorial synthetic reaction allowed the introduction of pharmaceutically privileged 2-thiobenzimidazole and 2-thiobenzoxazole scaffold.