A5051040722- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Nutrition, Genetics, and Disease
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Cancer Risks and Factors
- Cancer-related molecular mechanisms research
- Advanced Biosensing Techniques and Applications
- Soft tissue tumor case studies
- Global Cancer Incidence and Screening
- BRCA gene mutations in cancer
- Radiomics and Machine Learning in Medical Imaging
- Bone Tumor Diagnosis and Treatments
- Oral and Maxillofacial Pathology
- Gene expression and cancer classification
University of Birmingham
2020-2024
Children Cancer Hospital
2022-2024
Cairo University
2020-2024
Queen Elizabeth Hospital Birmingham
2020-2024
BackgroundRecent clinical evidence showed that breast cancer with low HER2 expression levels responded to trastuzumab deruxtecan therapy. The HER2-low cancers comprise immunohistochemistry (IHC) score 1+ and 2+ ISH non-amplified tumours, currently classified as negative. Little data exists on the reproducibility of pathologists reporting cancer.Patient methodsSixteen expert UK National Coordinating Committee for Breast Pathology scored 50 digitally scanned IHC slides. overall level...
There are limited data on the role of multigene tests and their correlation with immunohistochemistry (IHC), especially core biopsy. MammaTyper is a quantitative conformite Europeeanne (CE) marked, National Institute for Health Care excellence (NICE) approved, in vitro diagnostic real-time polymerase chain reaction (RT-qPCR) test assessment mRNA expression four biomarkers (ESR1, PGR, ERBB2, MKI67).
The assessment of PD-L1 expression in TNBC is a prerequisite for selecting patients immunotherapy. accurate pivotal, but the data suggest poor reproducibility. A total 100 core biopsies were stained using VENTANA Roche SP142 assay, scanned and scored by 12 pathologists. Absolute agreement, consensus scoring, Cohen's Kappa intraclass correlation coefficient (ICC) assessed. second scoring round after washout period to assess intra-observer agreement was carried out. occurred 52% 60% cases...
Breast cancer poses a global health challenge, yet the influence of ethnicity on tumor microenvironment (TME) remains understudied. In this investigation, we examined immune cell infiltration in 230 breast samples, emphasizing diverse ethnic populations. Leveraging tissue microarrays (TMAs) and core applied multiplex immunofluorescence (mIF) to dissect subtypes across TME regions. Our analysis revealed distinct distribution patterns, particularly enriched aggressive molecular triple-negative...
Breast cancer poses a global health challenge, yet the influence of ethnicity on tumor microenvironment (TME) remains understudied. In this investigation, we examined immune cell infiltration in 230 breast samples, emphasizing diverse ethnic populations. Leveraging tissue microarrays (TMAs) and core applied multiplex immunofluorescence (mIF) to dissect subtypes across TME regions. Our analysis revealed distinct distribution patterns, particularly enriched aggressive molecular triple-negative...
Breast cancer (BC) in non-Caucasian females is understudied and its management based on Caucasian data. 30 % of the West Midlands are non-Caucasian. We aimed to elucidate pathologic features, molecular profile, outcome breast cancer.Breast cancers (BCs) different ethnic origins diagnosed at a large Birmingham tertiary referral hospital between 2000 2016 were identified. Detailed clinical histological data collected statistically analyzed.Out 7554 BC cases, 749 ancestry median age 51 years....