A5090851450- Epigenetics and DNA Methylation
- Microplastics and Plastic Pollution
- Gut microbiota and health
- RNA modifications and cancer
- Diet and metabolism studies
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Acute Myeloid Leukemia Research
- Graphene and Nanomaterials Applications
- Animal testing and alternatives
- Nanoparticles: synthesis and applications
- Carcinogens and Genotoxicity Assessment
- IL-33, ST2, and ILC Pathways
- Cancer, Hypoxia, and Metabolism
- Hematopoietic Stem Cell Transplantation
- Effects and risks of endocrine disrupting chemicals
- Mesenchymal stem cell research
- Adipose Tissue and Metabolism
- Tryptophan and brain disorders
- Head and Neck Cancer Studies
- Immunotoxicology and immune responses
- biodegradable polymer synthesis and properties
- Iron Metabolism and Disorders
- Effects of Radiation Exposure
- Glutathione Transferases and Polymorphisms
Capital Medical University
2021-2024
Micro-/nanoplastics (MNPLs), novel environmental pollutants, widely exist in the environment and life bring health risks. Previous studies have shown that NMPLs can penetrate bone marrow, but whether they cause hematopoietic damage remains uncertain. In this study, C57BL/6J mice were treated with polystyrene MNPLs (PS-MNPLs, 10 μm, 5 μm 80 nm) at 60 μg doses for 42 days by intragastric administration. We evaluated toxicity induced potential mechanisms via combining 16S rRNA, metabolomics,...
Due to the annual increase in its production and consumption occupational environments, adverse blood outcomes caused by benzene are of concern. However, mechanism benzene-induced hematopoietic damage remains elusive. Here, we report that exposure causes a dose-dependent manner is associated with disturbances gut microbiota-long chain fatty acids (LCFAs)-inflammation axis. C57BL/6J mice exposed for 45 days were found have significant reduction whole cells suppression hematopoiesis, an...
Benzene exposure leads to hematopoietic dysfunction and is characterized clinically by a decrease in blood cells, but the underlying mechanisms remain elusive. Disturbed gut microbiota may induce host metabolic, immune disorders onset of disease. However, characterization microbiota, metabolism, cytokines their association with benzene-induced toxicity lacks systematic evidence. Here, microbiomics, metabolomics cytokine network were applied find out critical characteristics metabolism mice...