A5024393812- Systemic Lupus Erythematosus Research
- Adenosine and Purinergic Signaling
- Perfectionism, Procrastination, Anxiety Studies
- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Immune Cell Function and Interaction
- Advanced Drug Delivery Systems
- Childhood Cancer Survivors' Quality of Life
- Graphene and Nanomaterials Applications
- Workplace Health and Well-being
- Nanoparticle-Based Drug Delivery
- Liver Diseases and Immunity
- Testicular diseases and treatments
- Extracellular vesicles in disease
Renji Hospital
2021-2023
Shanghai Jiao Tong University
2008-2021
Fudan University
2015
Shanghai Cancer Institute
2008
B cell self-tolerance is maintained through multiple checkpoints, including restraints on intracellular signaling and trafficking. P2RY8 a receptor with established roles in germinal center (GC) migration inhibition growth regulation. Somatic variants are common GC-derived lymphomas. Here, we identify germline novel or rare missense lupus kindreds the related antiphospholipid syndrome, “de novo” variant child severe nephritis. All decreased protein expression, F-actin abundance, GPCR-RhoA...
The aim of this study is to investigate the alterations choroidal thickness (CT) in juvenile systemic lupus erythematosus (JSLE) using enhanced depth imaging optical coherence tomography (EDI-OCT). We also aimed assess whether CT parameters correlated with health status JSLE patients.JSLE patients and age- sex-matched healthy subjects were recruited. A detailed ophthalmological examination was applied all participants. measurements acquired macular region EDI-OCT. Moreover, a spectrum...
Abstract To develop an intravenous nanoparticle delivery system for a cancer drug (i.e., DHAQ, mitoxantrone), the synthesis of biodegradable polyester polymer with hydrophilic polyethylene glycol chains, preparation DHAQ‐loaded nanoparticles from such and biodistribution drug‐loaded particles were investigated in this article. Biodegradable monomethoxy poly(ethylene glycol)‐poly (lactide‐ co ‐glycolide)‐monomethoxy glycol) (MeO‐PEG‐PLGA‐PEG‐OMe, PELGE) copolymers synthesized by ring‐opening...
<h3>Context:</h3> Nearly half of all US adults have hypertension. It is more common in Black than other racial/ethnic groups. <h3>Objective:</h3> Describe adults' preferences for managing <h3>Study Design and Analysis:</h3> Cross-sectional study. Descriptive statistics chi-squared tests. <h3>Setting:</h3> One health care system New York City ResearchMatch, a NIH-funded national volunteer registry people interested research studies. <h3>Population Studied:</h3> 18 over with hypertension...
Exosomes are small membrane vesicles with a size of 40~100 nm in diameter released ubiquitously by cells. They contain large amount microRNAs and proteins play critical role intercellular communication. Tumor cells can release more exosomes than normal These influence tumor environment transferring proteins, RNAs, lipids between cells, thus aiding invasion metastasis. This paper reviewed the structure characteristics, biogenesis, secretion pathway, function radiation-induced discussed its...
Exaggerated PI3K/AKT signaling abrogates B cell tolerance and results in autoimmunity. P2RY8 is a repressor of AKT-mediated activation that also restrains migration. Here we identified de novo, novel missense variant child with severe lupus nephritis, an ultrarare proband antiphospholipid syndrome, less rare six patients. These variants impaired protein expression function, leading to increased AKT ERK activity migration, diminished follicular confinement. By contrast, overexpression...