A5012549542- Mitochondrial Function and Pathology
- Lipid metabolism and biosynthesis
- Photosynthetic Processes and Mechanisms
- Biochemical Acid Research Studies
- Pancreatic function and diabetes
- Genomics and Rare Diseases
- Single-cell and spatial transcriptomics
- CRISPR and Genetic Engineering
- Metabolism, Diabetes, and Cancer
- Mechanisms of cancer metastasis
Baylor College of Medicine
2015-2017
Neurological Research Institute
2017
Texas Children's Hospital
2017
University of North Carolina at Chapel Hill
2011
Reactive oxygen species (ROS) and mitochondrial defects in neurons are implicated neurodegenerative disease. Here, we find that a key consequence of ROS neuronal dysfunction is the accumulation lipid droplets (LD) glia. In Drosophila, triggers c-Jun-N-terminal Kinase (JNK) Sterol Regulatory Element Binding Protein (SREBP) activity leading to LD glia prior or at onset neurodegeneration. The accumulated lipids peroxidated presence ROS. Reducing peroxidation via targeted lipase overexpression...
Elevated reactive oxygen species (ROS) induce the formation of lipids in neurons that are transferred to glia, where they form lipid droplets (LDs). We show glial and neuronal monocarboxylate transporters (MCTs), fatty acid transport proteins (FATPs), apolipoproteins critical for LD formation. MCTs enable glia secrete absorb lactate, which is converted pyruvate acetyl-CoA neurons. Lactate metabolites provide a substrate synthesis acids, processed by FATP apolipoproteins. In presence high...
AMP-activated protein kinase (AMPK) is a key energy sensor that regulates metabolism to maintain cellular balance. AMPK activation has also been proposed mimic benefits of caloric restriction and exercise. Therefore, identifying downstream targets could elucidate new mechanisms for maintaining homeostasis. We identified the phosphotransferase nucleoside diphosphate (NDPK), which maintains pools nucleotides, as direct target through use two-dimensional differential in-gel electrophoresis....